Search results for "BREAST"

Biological effect of an hybrid anticancer agent based on kinase and histone deacetylase inhibitor on breast cancer cells

2014

HUMAN MILK IS NOT “MERELY NUTRITIOUS”: HOW ITS BIOACTIVE ROLE CAN INFLUENCE CHILD HEALTH

2021

Maternal milk represents the best food for the newborn, providing specific physiologic advantages over the other sources of nutrition. It also contains many hundreds to thousands of bioactive molecules that protect against infection (i.e. IgA), inflammation (i.e. 5-methylthioadenosine) and contribute to eliciting strong immune responses in breastfed children (i.e. allergens or viral antigens). Quality and quantity of breast milk components may influence the development of infant body composition in the first years of life; in particular, it has been shown that a different composition of human oligosaccharides (HMOs) in overweight/obese women’s human milk can be correlated with her offspring…

Molecular Subtypes, Metastatic Pattern and Patient Age in Breast Cancer: An Analysis of Italian Network of Cancer Registries (AIRTUM) Data

2021

Breast cancer stage at diagnosis, patient age and molecular tumor subtype influence disease progression. The aim of this study was to analyze the relationships between these factors and survival in breast cancer patients among the Italian population using data from the AIRTUM national database. We enrolled women with primary breast cancer from 17 population-based cancer registries. Patients were subdivided into older (>69 years), middle (50–69 years) and younger age groups (<50 years) and their primary tumors categorized into four molecular subtypes based on hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status. There were 8831 patients diagnosed betwe…

Vesiclepedia:A Compendium for Extracellular Vesicles with Continuous Community Annotation

2012

Vesiclepedia is a community-annotated compendium of molecular data on extracellular vesicles.

Health-related Quality of Life of Breast Cancer Survivors Attending an Exercise Intervention Study : A Five-year Follow-up

2020

Background/Aim: As the number of breast cancer survivors is increasing, their long-term health-related quality of life (HRQoL)has become an important issue. The aim of the study is to follow up the HRQoL of breast cancer survivors (BCS) in a prospectiverandomized exercise intervention study and to compare HRQoL to that of the age-matched general female population. Patients and Methods: Following adjuvant treatment, 537 patients aged 35-68 and capable of exercise training were randomized to a 12-monthexercise trial. In 182 of those patients, HRQoL was measured by the generic 15D at baseline and followed up for five years.Furthermore, the HRQoL of all BCS answering the 15D at five-year follow…

Long-Term Breastfeeding: The Embodied Experiences of Finnish Mothers

2019

Mothers’ experiences constitute a central and widely discussed issue within feminist breastfeeding research. Less is said however, about long-term breastfeeding in relation to embodiment. This article analyses the embodied experiences of Finnish mothers who have breastfed for over a year. Through a feminist lens, and an inductive qualitative content analysis, the written accounts of 39 long-term breastfeeding mothers were analysed, to show how mothers reflect on embodiment while breastfeeding long-term. Mothers described their embodied experiences in relation to four themes: functionality of the body; tiredness; beauty norms; and pleasure. The study reveals their accounts of bodily changes …

P056 Occupational exposure to metals and risk of breast, chronic lymphocytic leukaemia, colorectal, prostate, and stomach cancer in the MCC-spain cas…

2016

Arsenic, cadmium, chromium, and nickel are classified by IARC as human carcinogens (Group 1), while lead as a probable/possible carcinogen to humans (Group 2A). We explored associations between occupational exposure to metals and breast, chronic lymphocytic leukaemia (CLL), colorectal, prostate, and stomach cancer in the MCC-Spain population based case-control study. Methods The analyses were based on 3047 controls, and 1499 breast, 1539 colorectal, 332 CLL, 1070 prostate, and 382 stomach cancer cases. Occupational exposure to arsenic, cadmium, chromium, iron, lead and nickel was assessed using the MatEmEsp job-exposure matrix. Logistic regression models accounting for education, sex, geogr…

Receptor-mediated uptake of boron-rich neuropeptide y analogues for boron neutron capture therapy.

2014

Peptidic ligands selectively targeting distinct G protein-coupled receptors that are highly expressed in tumor tissue represent a promising approach in drug delivery. Receptor-preferring analogues of neuropeptide Y (NPY) bind and activate the human Y1 receptor subtype (hY1 receptor), which is found in 90% of breast cancer tissue and in all breast-cancer-derived metastases. Herein, novel highly boron-loaded Y1 -receptor-preferring peptide analogues are described as smart shuttle systems for carbaboranes as (10) B-containing moieties. Various positions in the peptide were screened for their susceptibility to carbaborane modification, and the most promising positions were chosen to create a mu…

Mātes piena sastāvs un tā ietekmējošie faktori

2015

Darba mērķis Noteikt krūts piena sastāvu un tā ietekmējošos faktorus Latvijā dzemdējušām mātēm, kā arī salīdzināt iegūtos rezultātus ar citu valstu datiem. Materiāli un metodes Piena paraugi tika iegūti no mātēm (5.-7. vai 11.-28. laktācijas dienā), kuru jaundzimušie ārstējās Bērnu Klīniskās Universitātes slimnīcā jaundzimušo nodaļās. Piena analīze veikta Latvijas Lauksaimniecības universitātē (ph, blīvums, olbaltumvielu, tauku, glikozes un laktozes koncentrācija). Rezultāti Pētījumā tika iesaistītas 44 mātes, iegūti 39 piena paraugi 5.-7. laktācijas dienā; 11 piena paraugi 11. – 28. laktācijas dienā. 5. – 7. laktācijas dienas paraugu sastāvs un vidējā makroelementu koncentrācija (95% TI) b…

Comparison of breast milk composition among lactating women in Latvia

2016

Abstract Although benefits of breast-feeding have been known for a long time and breast milk is considered as ideal nutrition for infants, the composition of breast milk is still being studied, since breast milk differs among mothers and populations, as well as during different times of lactation. Further, no study has been performed among lactating women in Latvia during recent years. The objective of the study was to determine the breast milk composition and influencing factors among lactating women in Latvia in different lactation periods, as well as to compare the results with data from other countries. Fifty breast milk samples were obtained from 44 mothers (on the 5th-7th and 11th-28t…