Search results for "BRIEF"
showing 10 items of 347 documents
Funcionamiento neurocognitivo y psicosocial de pacientes con trastorno bipolar en una unidad de salud mental
2018
INTRODUCCION: Existe evidencia de que los pacientes que padecen Trastoro Bipolar (TB), e incluso sus familiares sanos, presentan patrones característicos de afectación de ciertos dominios neurocognitivos que persisten tras la remisión clínica o período de eutimia. La pérdida de funcionalidad psicosocial de estos pacientes se predice mejor con la presencia de alteraciones cognitivas que con variables clínicas o evolutivas. El clínico asistencial debería conocer si existe afectación o deterioro en las funciones neurocognitivas de sus pacientes pero en el medio asistencial cotidiano es difícil poder evaluar adecuadamente las funciones cognitivas y tampoco se acostumbra a cuantificar la funcion…
Extremely Low Frequency Magnetic Fields Do Not Affect LTP-Like Plasticity in Healthy Humans.
2020
Introduction: Several studies explored, in vitro, the biological effects of extremely low-frequency magnetic fields (ELF-MFs) and reported the induction of functional changes in neuronal activity. In particular, ELF-MFs can influence synaptic plasticity both in-vitro and in animal models. Indeed, some studies reported an increase in long-term potentiation (LTP) whereas others suggested its reduction. However, no specific study has investigated such effect in humans. Aims: To evaluate whether ELF-MFs affect the propensity of the human cortex to undergo LTP-like plasticity. Methods: We designed a randomized, single-blind, sham-controlled, cross-over study on 10 healthy subjects. Cortical plas…
The C-X-C Motif Chemokine Ligand 1 Sustains Breast Cancer Stem Cell Self-Renewal and Promotes Tumor Progression and Immune Escape Programs
2021
Breast cancer (BC) mortality is mainly due to metastatic disease, which is primarily driven by cancer stem cells (CSC). The chemokine C-X-C motif ligand-1 (CXCL1) is involved in BC metastasis, but the question of whether it regulates breast cancer stem cell (BCSC) behavior is yet to be explored. Here, we demonstrate that BCSCs express CXCR2 and produce CXCL1, which stimulates their proliferation and self-renewal, and that CXCL1 blockade inhibits both BCSC proliferation and mammosphere formation efficiency. CXCL1 amplifies its own production and remarkably induces both tumor-promoting and immunosuppressive factors, includingSPP1/OPN,ACKR3/CXCR7,TLR4,TNFSF10/TRAILandCCL18and, to a lesser exte…
Lipoproteins and Cardiovascular Disease: An Update on the Clinical Significance of Atherogenic Small, Dense LDL and New Therapeutical Options
2021
Dyslipidemia is a potent risk factor for the genesis and progression of cardiovascular disease (CVD), and both the concentration and type of low-density lipoproteins (LDL) augment this association. The small, dense LDL (sdLDL) subfraction is the subtype which is most strongly predictive of atherosclerosis and cardiovascular events. In addition to the traditionally available lipid-lowering treatment options, certain novel therapies have been shown to favorably impact sdLDL, among them the antidiabetic class of agents known as glucagon-like peptide 1 receptor agonists (GLP1-RAs). These drugs seem to alter the pathophysiologic mechanisms responsible for the formation and accumulation of athero…
Communication role on perception and beliefs of EU citizens about science
2020
Este documento presenta un conjunto de recomendaciones basadas en el conocimiento de las consultas públicas de CONCISE. Los puntos se enumeran según los diferentes destinatarios: comunicadores científicos, responsables políticos, científicos y público en general. El principal objetivo de CONCISE es determinar el papel que desempeña la comunicación científica en la formación de creencias, percepciones y conocimientos sobre cuestiones científicas. Para lograr este objetivo, CONCISE llevó a cabo cinco consultas públicas en Lisboa (Portugal), Valencia (España), Vicenza (Italia), Trnava (Eslovaquia) y Lodz (Polonia) con la participación de cerca de 500 ciudadanos. Esto permitió al consorcio reco…
The Impact of Age on the Association Between Physical Activity and White Matter Integrity in Cognitively Healthy Older Adults
2020
Cognition emerges from coordinated processing among distributed cortical brain regions, enabled through interconnected white matter networks. Cortical disconnection caused by age-related decline in white matter integrity (WMI) is likely to contribute to age-related cognitive decline. Physical activity (PA) has been suggested to have beneficial effects on white matter structure. However, its potential to counteract age-related decline in WMI is not yet well established. The present explorative study analyzed if PA was associated with WMI in cognitively healthy older adults and if this association was modulated by age. Forty-four cognitively healthy older individuals (aged 60–88 years) with d…
Reliable Correlational Cuing While Controlling for Most-Recent-Pairing Effects.
2020
Irrelevant aspects of the environment or irrelevant attributes of task-relevant stimuli can have important and reliable effects on behavior. When the specific values of an irrelevant stimulus attribute are correlated with different responses, a correlational-cuing effect is observed: faster and more accurate responses when the correlation is positive than when it is negative. Previous work has shown that this effect is not due to simple differences in how often the specific stimuli are being presented, and most explanations of the effect have stressed the clear parallels with classical associative learning. Very recently, however, evidence in favor of an alternative model has been presented…
The Sense of Belonging to the Country: Integrative Relationships and Spatiotemporal Commitment
2020
The satisfaction of the need to belong reflects in the sense of being an integrative part of the group or social system. There is some lack of empirical evidence for the structure of this sense at the macro level. This study assessed a two-dimensional model of the sense of belonging to the country, which included relational and spatiotemporal components. Participants were 539 university students from 18 to 50 (74% females). Questions regarding involvement, perceived acceptance, sense of commonality, and feeling at home represented the relational component of the sense of belonging. Four temporal categories—the recent past, present, and the near and distant future—were included in the assess…
Dreams and Trauma Changes in the Manifest Dreams in Psychoanalytic Treatments - A Psychoanalytic Outcome Measure.
2021
Although psychoanalysts are interested in symptom reduction as an outcome, they are looking for instruments to measure sustaining changes in the unconscious mental functioning. In this article it is discussed that conceptually well-founded transformation of manifest dreams analyzed with precise empirical methods could be considered as a promising indicator for such therapeutic changes. We are summarizing a dream generation model by Moser and von Zeppelin which has integrated a large interdisciplinary knowledge base of contemporary dream and sleep research. Based on this model the authors have developed a valid and reliable coding system for analyzing manifest dreams, the Zurich Dream Proces…
Reduced Admissions for Cerebrovascular Events during COVID-19 Outbreak in Italy
2020
Supplemental Digital Content is available in the text.