Search results for "BUP"
showing 10 items of 168 documents
Farmaceitisko vielu ekotoksiskuma riska novērtējums uz mikroorganismiem notekūdeņos
2017
Vides piesārņojums ar AFV šobrīd ir aktuāla problēma un ir nepieciešamas zināšanas par iespējamajām šī piesārņojuma sekām. Darba mērķis bija pētīt baktēriju P.fluorescens AM 11 un M.luteus fizioloģiskās atbildes reakciju uz dažādu farmaceitisko vielu klātbūtni, kā arī novērtēt kā paaugstinātas ibuprofēna koncentrācijas ietekmē aktīvo dūņu baktēriju sabiedrības daudzveidību un antibiotiku rezistences veidošanos. Antibiotika ciprofloksacīns uzrāda visspēcīgāko inhibējošo efektu uz P.fluorescens AM 11 un M.luteus baktēriju kultūrām periodiskā kultūrā mikroplatēs. Augstas ibuprofēna koncentrācijas aktīvajāss dūņās veicina Sphingomonadales un Enterobacteriales kārtas baktēriju attīstību un uzrād…
Validation of Dissolution Testing with Biorelevant Media: An OrBiTo Study.
2017
Dissolution testing with biorelevant media has become widespread in the pharmaceutical industry as a means of better understanding how drugs and formulations behave in the gastrointestinal tract. Until now, however, there have been few attempts to gauge the reproducibility of results obtained with these methods. The aim of this study was to determine the interlaboratory reproducibility of biorelevant dissolution testing, using the paddle apparatus (USP 2). Thirteen industrial and three academic laboratories participated in this study. All laboratories were provided with standard protocols for running the tests: dissolution in FaSSGF to simulate release in the stomach, dissolution in a singl…
Development of an lbuprofen-Releasing Biodegradable PLA/PGA Electrospun Scaffold for Tissue Regeneration
2009
Our aim was to develop a biodegradable fibrous dressing to act as a tissue guide for in situ wound repair while releasing Ibuprofen to reduce inflammation in wounds and reduce pain for patients on dressing changes. Dissolving the acid form of Ibuprofen (from 1% to 10% by weight) in the same solvent as 75% polylactide, 25% polyglycolide (PLGA) polymers gave uniformly loaded electrospun fibers which gave rapid release of drug within the first 8 h and then slower release over several days. Scaffolds with 10% Ibuprofen degraded within 6 days. The Ibuprofen released from these scaffolds significantly reduced the response of fibroblasts to major pro-inflammatory stimulators. Fibroblast attachment…
Direct chromatographic study of the enantioselective biodegradation of ibuprofen and ketoprofen by an activated sludge
2018
[EN] The quantification of the enantiomeric fraction (EF) during the biodegradation process is essential for environmental risk assessment. In this paper the enantioselective biodegradation of ibuprofen, IBU, and ketoprofen, KET, two of the drugs most consumed, was evaluated. Biodegradation experiments were performed in batch mode using a minimal salts medium inoculated with an activated sludge (collected from a Valencian Waste Water Treatment Plant) and supplemented with the racemate of each compound. The inoculum activity was verified using fluoxetine as reference compound. The experimental conditions used (analyte concentration and volume of inoculum) were chosen according to OECD guidel…
Determination of non-steroidal anti-inflammatory drugs in water and urine using selective molecular imprinted polymer extraction and liquid chromatog…
2016
Abstract A selective solid-phase extraction was employed for the improvement of the determination of non-steroidal anti-inflammatory drugs (NSAIDs) in continental water and urine samples. Ketoprofen, naproxen, diclofenac, and ibuprofen were selected as target analytes due to they are the most frequently administered and consumed NSAIDs. These compounds were extracted using molecular imprinted polymers and determined by liquid chromatography with diode array (DAD), and tandem-mass spectrometry (MS–MS) detectors. Performance of DAD and MS–MS detectors was evaluated throughout this study. The obtained limits of quantification, after a 50-fold preconcentration solid-phase extraction, varied fro…
Distinguishing the roles of carrier and biofilm in filtering media for the removal of pharmaceutical compounds from wastewater
2017
Abstract Pharmaceutical compounds (PCs) represent a large group of micropollutants in wastewaters (WW) worldwide. Many PCs are resistant to conventional WW treatment. Moreover, for some PCs the removal process is reversible. The aim of this study was to test three newly developed ceramic carriers for biofilm formation and PCs removal. The testing of untreated WW samples by liquid chromatography coupled to Orbitrap mass spectrometry allowed to detect the occurrence of 18 PCs in the range from 26 ng/L to 20,688 ng/L, with the highest concentrations found for caffeine. Besides, among PCs with concentrations above 1,000 ng/L, ibuprofen (19,234 ng/L), naproxen (1,405 ng/L), xylazine (1,366 ng/L)…
Hydrophilic and Hydrophobic Polymeric Derivatives of Anti-Inflammatory Agents Such as Alclofenac, Ketoprofen, and Ibuprofen
1991
Macromolecular prodrugs of a hydrophilic polymer [α,β-poly( N- hydroxyethyl)-DL-aspartamide (PHEA)] was used as a drug carrier. Three poly- (HEA)-NSAID adducts were studied: poly(HEA)-Alclofenac, poly(HEA)-Keto profen, and poly(HEA)-Ibuprofen. Prodrugs with different drug content were synthesized both as water-soluble and water-insoluble agents. Hydrolysis of water-soluble adducts in a simulated gastric juice was studied.
Bupivakaīna hidrohlorīda un lidokaīna hidrohlorīda degradācija
2015
Bupivakaīna hidrohlorīda un lidokaīna hidrohlorīda degradācija. Bakalaura darbs. Rozenvalds R., darba vadītājs Dr.chem. Nakurte I. un Mag. ķīm Kuprevičs K., 37 lapas, 5 attēli, 10 tabulas, 46 literatūras avoti, 19 attēli pielikumā. Latviešu valodā. BUPIVAKAĪNS, LIDOKAĪNS, DEGRADĀCIJA, PIEMAISĪJUMI, GĀZU HROMATOGRĀFIJA, AUGSTI EFEKTĪVĀ ŠĶIDRUMA HROMATOGRĀFIJA Literatūras aprakstā ir apkopota informācija par bupivakaīna hidrohlorīdu un lidokaīna hidrohlorīdu, šo preparātu īpašībām, pielietojumu farmācijā un zināmajiem piemaisījumiem. Literatūras apskatā veikts vispārējs ieskats aktīvo vielu stabilitātē un piemaisījumu noteikšanas analītisko metožu validācijā. Darba eksperimentālajā daļā ir ve…
Bupivacaine 0.5% versus articaine 4% for the removal of lower third molars. A crossover randomized controlled trial.
2012
Objective: To compare the anesthetic action of 0.5% bupivacaine in relation to 4% articaine, both with 1:200,000 epinephrine, in the surgical removal of lower third molars. As a secondary objective hemodynamic changes using both anesthetics were analyzed. Study Design: Triple-blind crossover randomized clinical trial. Eighteen patients underwent bilateral removal of impacted lower third molars using 0.5% bupivacaine or 4% articaine in two different appointments. Preoperative, intraoperative and postoperative variables were recorded. Differences were assessed with McNemar tests and repeated measures ANOVA tests. Results: Both solutions exhibited similar latency times and intraoperative effic…
Effects of acute administration of bupropion on behavior in the elevated plus-maze test by NMRI mice
2004
Bupropion attenuates some symptoms of nicotine abstinence, although its effects on anxiety are unclear. The present study investigates acute effects of bupropion (5, 10, 20 and 40 mg/kg) on anxiety as expressed in the elevated plus-maze test in male NMRI mice. Given the influence of locomotion in this test, effects of bupropion were also evaluated in an actimeter. Spontaneous motor activity remained significantly increased in mice treated with 10, 20 and 40 mg/kg of bupropion during the 60 min recorded. Results from the elevated plus-maze showed that 20 mg/kg increased total arm entries and 40 mg/kg increased total and open arm entries. Although the increase in the number of visits to the o…