Hydrophilic and Hydrophobic Polymeric Derivatives of Anti-Inflammatory Agents Such as Alclofenac, Ketoprofen, and Ibuprofen

6533b871fe1ef96bd12d2281

RESEARCH PRODUCT

Hydrophilic and Hydrophobic Polymeric Derivatives of Anti-Inflammatory Agents Such as Alclofenac, Ketoprofen, and Ibuprofen

Giovanna Pitarresi Bianca Carlisi Gaetano Giammona Giacomo Fontana

subject

Ketoprofen chemistry.chemical_classification Polymers and Plastics Chemistry medicine.drug_class 0206 medical engineering Bioengineering 02 engineering and technology Polymer Prodrug Alclofenac 021001 nanoscience & nanotechnology Ibuprofen 020601 biomedical engineering Anti-inflammatory Adduct Biomaterials Polymer chemistry Materials Chemistry medicine Organic chemistry 0210 nano-technology Drug carrier medicine.drug

description

Macromolecular prodrugs of a hydrophilic polymer [α,β-poly( N- hydroxyethyl)-DL-aspartamide (PHEA)] was used as a drug carrier. Three poly- (HEA)-NSAID adducts were studied: poly(HEA)-Alclofenac, poly(HEA)-Keto profen, and poly(HEA)-Ibuprofen. Prodrugs with different drug content were synthesized both as water-soluble and water-insoluble agents. Hydrolysis of water-soluble adducts in a simulated gastric juice was studied.

year	journal	country	edition	language
1991-04-01	Journal of Bioactive and Compatible Polymers

https://doi.org/10.1177/088391159100600202

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