Search results for "Bacco"

Analysing the Spanish smoke-free legislation of 2006: a new method to quantify its impact using a dynamic model.

2011

Background: There are many models that study aspects of smoking habits: the influence of price, tax, relapse time, and the effects of prohibition. There are also studies examining the effects of the Spanish smoke-free law. We wanted to build a model able to separate the effect of the law from the pre-law evolution of smoking habits. Methods: Using data from the Spanish Ministry of Health and Social Policy, we developed a dynamic model of tobacco use. The model projects the evolution over time of the number of non-smokers, smokers and ex-smokers before 2006. Then, we compared the predictions of the model with data for the years after the law came into force, 2006 and 2009. Results: We show t…

Proteasome comprising a beta1 inducible subunit acts as a negative regulator of NADPH oxidase during elicitation of plant defense reactions.

2005

Elicitation of defense reactions in tobacco by cryptogein, triggered a production of active oxygen species (AOS) via the NADPH oxidase, NtrbohD, and an accumulation of beta1din, a defense induced beta-type subunit of 20S proteasome. The proteasome inhibitor, MG132, stimulated this AOS production. Tobacco cells transformed with sense constructs of beta1din showed an inhibition of the AOS production following elicitin treatment, whereas the antisense transformed cells showed a strongly enhanced AOS production. In cells transformed with sense construct of beta1din, the NtrbohD transcripts failed to be induced by cryptogein as observed in control and antisense transformed cells. Conversely, in …

La qualità dell’aria indoor: una priorità ambientale e sanitaria

2009

Specchio Riflesso. A multidimensional intervention for the primary prevention of cigarette smoking during pre-adolescence

2019

Smoking is very common among adolescents; nowadays, young people start smoking very early, before being 15 years old. Effective primary prevention interventions are needed to contrast tobacco use in young age. For these reasons, the section of Milan of the Italian League for the Fight Against Cancer has developed Specchio Riflesso (SR), an innovative intervention based on the social theatre methodology and aimed at promoting preadolescents’ self-reflection on their identity and their role within a group and facilitating their critical reflection toward tobacco smoking. Aim of this contribution was to evaluate its effectiveness. One hundred and ninety-one students were involved in SR, consis…

Tobacco Use Documenting Policy and Its Association With Pupils’ Smoking and Their Perception of the Enforcement of School Smoking Bans in Finland

2014

Finnish national data sets on schools (N = 496) and pupils (N = 74,143; 14–16 years) were used to study whether a systematic documenting policy for the violations of school smoking bans was associated with pupils’ smoking and their perceptions on the enforcement of smoking bans. Attending a school with a systematic documenting policy was associated with perceptions that smoking is prohibited and restrictions monitored, with lower levels of smoking in the vicinity of the school during the school day, but not with smoking prevalence. Findings suggest that a consistent documenting policy could be an effective tool for reducing pupils’ smoking in schools.

Beclomethasone dipropionate and formoterol reduce oxidative/nitrosative stress generated by cigarette smoke extracts and IL-17A in human bronchial ep…

2013

Interleukin-17A (IL-17A), cigarette smoke and oxidative/nitrosative stress are involved in inflammatory airway diseases, and the mechanisms behind these processes are still poorly understood. We investigated whether recombinant human IL-17A (rhIL-17A), in combination with cigarette smoke extracts (CSE), increases the levels of inducibile nitric oxide synthase (iNOS), reactive oxygen species, nitrotyrosine (NT) and the activation of signal transducer and activator of transcription 1 (STAT-1) in normal human bronchial epithelial cells (16HBE). The effect of beclomethasone dipropionate (BDP), formoterol and their combination was also evaluated. We demonstrated that rhIL-17A or CSE alone increa…

Expression of a reporter gene is reduced by a ribozyme in transgenic plants

1994

A chimeric gene encoding a ribozyme under the control of the cauliflower mosaic virus (CaMV) 35S promoter was introduced into transgenic tobacco plants. In vivo activity of this ribozyme, which was designed to cleave npt mRNA, was previously demonstrated by transient expression assays in plant protoplasts. The ribozyme gene was transferred into transgenic tobacco plants expressing an rbcS-npt chimeric gene as an indicator. Five double transformants out of sixteen exhibited a reduction in the amount of active NPT enzyme. To measure the amount of ribozyme produced, in the absence of its target, the ribozyme and target genes were separated by genetic segregation. The steady-state concentration…

Uzņēmējdarbības paplašināšana starptautiskā līmenī: zīmola veidošanas procesi un kompānijas "British American Tobacco" zīmola stratēģijas

2018

Globālo tirgu raksturo vairāki vietējie un starptautiskie produkti, kas nemitīgi cīnās par vietu un lietotāju atzinību, tāpēc nevar novērtēt par zemu globālās zīmolu popularizēšanas nozīmi. Uzņēmumiem ir jāreklamē savi produkti globālā mērogā, izmantojot dažādus efektīvus mediju un izplatīšanas kanālus. Jāuzver, ka dažādus kanālus izmanto uzņēmumi, kas iziet starptautiskajos tirgos, kas, savukārt, ir noteicis globālās zīmolu popularizēšanas stratēģijas, kas ir spēkā uzņēmumā. Kad uzņēmumi izlemj paplašināties starptautiskā līmenī, izvēloties tirgus stratēģijas, būtiska loma ir standartizācijai un adaptācijai. Tad rodas jautājums, kā uzņēmumi kontrolē un uzrauga zīmola veidošanas procesus da…

First nation-wide estimation of tobacco consumption in Spain using wastewater-based epidemiology

2020

Wastewater-based epidemiology (WBE) has become a very useful tool to monitor a population's drug consumption or exposure to environmental and food contaminants. In this work, WBE has been applied to estimate tobacco consumption in seven Spanish regions. To this end, 24 h composite wastewater samples were taken daily for one week in 17 wastewater treatment plants, covering altogether a population of ca. 6 million inhabitants. The samples were treated by enzymatic deconjugation and the wastewater content of two human-specific nicotine metabolites (namely, cotinine and trans-3′-hydroxycotinine) was measured to estimate the daily consumption of nicotine. The population-weighted average nicotine…

Cadmium availability at different soil pH to transgenic tobacco overexpressing ferritin

2003

International audience; Knowledge on physiological mechanisms and plant metabolism can be used to enhance metal uptake. The capacity to uptake metals of transgenic tobaccos overexpressing ferritin in plastids (P6) or in cytoplasm (C5) and a control tobacco (A) is assessed in three polluted soils from the same soil series, with a similar Cd content, but displaying pH from 5.8 to 7 (8b2, 8b3, S11). Differences in dry leave weight were not significant between the three tobaccos growing on each soil. Iron concentration in ferritin overexpression either in P6 or in C5 tobaccos increased only on the S11 soil, which had a soil pH 7, in comparison to A tobacco. In both 8b2 and 8b3 soils at pH lower…