Search results for "Bayes theorem"
showing 4 items of 214 documents
Conditional predictive inference for online surveillance of spatial disease incidence
2011
This paper deals with the development of statistical methodology for timely detection of incident disease clusters in space and time. The increasing availability of data on both the time and the location of events enables the construction of multivariate surveillance techniques, which may enhance the ability to detect localized clusters of disease relative to the surveillance of the overall count of disease cases across the entire study region. We introduce the surveillance conditional predictive ordinate as a general Bayesian model-based surveillance technique that allows us to detect small areas of increased disease incidence when spatial data are available. To address the problem of mult…
Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants
2017
Background Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods For this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean systolic and mean diastolic blood pressure, and the prevalence of rai…
The Spatial Overlap of Police Calls Reporting Street-Level and Behind-Closed-Doors Crime: A Bayesian Modeling Approach
2021
Traditionally, intimate-partner violence has been considered a special type of crime that occurs behind closed doors, with different characteristics from street-level crime. The aim of this study is to analyze the spatial overlap of police calls reporting street-level and behind-closed-doors crime. We analyzed geocoded police calls in the 552 census-block groups of the city of Valencia, Spain, related to street-level crime (N = 26,624) and to intimate-partner violence against women (N = 11,673). A Bayesian joint model was run to analyze the spatial overlap. In addition, two Bayesian hierarchical models controlled for different neighborhood characteristics to analyze the relative risks. Resu…
Single-cell analysis of population context advances RNAi screening at multiple levels
2012
Isogenic cells in culture show strong variability, which arises from dynamic adaptations to the microenvironment of individual cells. Here we study the influence of the cell population context, which determines a single cell's microenvironment, in image‐based RNAi screens. We developed a comprehensive computational approach that employs Bayesian and multivariate methods at the single‐cell level. We applied these methods to 45 RNA interference screens of various sizes, including 7 druggable genome and 2 genome‐wide screens, analysing 17 different mammalian virus infections and four related cell physiological processes. Analysing cell‐based screens at this depth reveals widespread RNAi‐induce…