Search results for "Beni"

Multiphoton Absorption of Myoglobin Nitric-Oxide complex: Relaxation by D-NEMD of a Stationary State

2012

ABSTRACT: The photodissociation and geminate recombination of nitric oxide in myoglobin, under continuous illumination, is modeled computationally. The relaxation of the photon energy into the protein matrix is also considered in a single simulation scheme that mimics a complete experimental setup. The dynamic approach to non-equilibrium molecular dynamics is used, starting from a steady state, to compute its relaxation to equilibrium. Simulations are conducted for the native form of sperm whale myoglobin and for two other mutants, V68W and L29F, illustrating a fair diversity of spatial and temporal geminate recombination processes. Energy flow to the heme and immediate protein environment …

Proteins in Amorphous Saccharides: Structural and Dynamical Insights on Bioprotection

2011

We report on experimental and simulative insights on saccharide-based bioprotection, obtained through the study of proteins embedded in amorphous saccharide matrices. The data presented come from a complementary set of techniques (FTIR, MD simulations and SAXS), which provides a description of the bioprotection mechanism from the atomistic to the macroscopic level. The results concur to draw a picture in which bioprotection by saccharides can be explained in terms of a tight anchorage of the protein surface to a stiff matrix, via extended hydrogen-bond networks, whose properties are defined by all its components, and are strongly dependent on the water content. In particular, they show how …

Materiali nanostrutturati e tecnologie innovative per il recupero e la conservazione dei beni architettonici: un approccio interdisciplinare

2009

Tumours of Nasal Septum: A Retrospective Study of 32 Patients

2022

Objective: Tumours of the nasal septum are a rare and heterogeneous group of lesions in the sinonasal tract. The management of the different lesions of this site is debated. The aim of this study is to share our experience on a rare clinical condition and stimulate other centres to publish theirs. Methods: We retrospectively analysed the databases of sinonasal tumours treated at the Sections of Otolaryngology (ENT) of two University Hospitals (Palermo and Genova) between 2012 and 2020. Results: From the two databases, a cohort of 32 patients with tumours of nasal septum were selected. All patients underwent an endoscopic examination. Large tumours underwent preoperative computed tomography …

A Classification of Palermo Historical Centre Heritage based on the local seismic response

2009

A very high density of monumental heritage falls within Palermo Historical Centre, an area characterized by high variability of near surface geology and soil physical-mechanical properties on a very short distance scale, even few meters. So, neighboring heritage elements can have a totally different hazard exposition. Within a project regarding Palermo area (Project 7T7, Cluster 29, funded by Ministero dell’Università e della Ricerca, Italy) a very reliable high density stratigraphic-geotechnical dataset has been assembled, by means of a careful data reviewing process. This dataset has been stored in a Geographic Information System (GIS) application, named City-GIS, having all GIS functions…

Caratterizzazione delle neoplasie epatiche benigne: ecografia ad inversione impulso con mezzo di contrasto di I e II generazione a confronto

2006

Setting the basis for the study of intermediate conformers of human neuroserpin by Double Electron Electron Resonance

2012

The Double Electron Electron Resonance (DEER) is an innovative technique that allows to measure the distance distribution between two spin labels within a range of 2-8 nm. This technique does not require crystalline samples, thus it is possible to determine the position of two different spin labelled domains of intrinsically flexible macromolecular systems. Our idea is to determinate the structural details of the intermediate conformers of human neuroserpin (hNS) by DEER. hNS is a protein that in the native state is folded in a metastable conformation. In particular conditions, hNS can either adopt a more stable conformation with the reactive centre loop (RCL) inserted into a β-sheet (laten…

Is the polypeptide chain necessary for the dynamical transition in proteins?

2011

New insight on metal finds of the Punic Ship of Lilibeum

2020

In this paper, the investigation of some finds (two nails, a head and a long shaft nail, and a fragment of Lead sheathing) belonging to the wreck of the Punic ship and exhibited at Museo Archeologico Regionale Lilibeo (Trapani, Italy), is reported. The X-ray Fluorescence Spectroscopy (XRF) allowed us to identify the elements constituting them making some discussion deductions about their composition and degradation occurred.

Modulation of Human Motor Cortical Excitability and Plasticity by Opuntia Ficus Indica Fruit Consumption: Evidence from a Preliminary Study through N…

2022

Indicaxanthin (IX) from Opuntia Ficus Indica (OFI) has been shown to exert numerous biological effects both in vitro and in vivo, such as antioxidant, anti-inflammatory, neuro-modulatory activity in rodent models. Our goal was to investigate the eventual neuro-active role of orally assumed fruits containing high levels of IX at nutritionally-relevant amounts in healthy subjects, exploring cortical excitability and plasticity in the human motor cortex (M1). To this purpose, we applied paired-pulse transcranial magnetic stimulation and anodal transcranial direct current stimulation (a-tDCS) in basal conditions and followed the consumption of yellow cactus pear fruits containing IX or white ca…