Search results for "Benzodioxole"

showing 3 items of 13 documents

CCDC 766948: Experimental Crystal Structure Determination

2010

Related Article: S.Ikonen, Nonappa, A.Valkonen, R.Juvonen, H.Salo, E.Kolehmainen|2010|Org.Biomol.Chem.|8|2784|doi:10.1039/c003228j

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersMethyl 4-(10'13'-dimethyl-1'2'4'5'6'7'8'9'10'11'12'13'14'15'16'17'-hexadecahydrospiro[13-benzodioxole-23'-cyclopenta[a]phenanthren]-17'-yl)pentanoateExperimental 3D Coordinates
researchProduct

CCDC 766949: Experimental Crystal Structure Determination

2010

Related Article: S.Ikonen, Nonappa, A.Valkonen, R.Juvonen, H.Salo, E.Kolehmainen|2010|Org.Biomol.Chem.|8|2784|doi:10.1039/c003228j

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersMethyl 4-(10'13'-dimethyl-7'12'-dioxo-1'2'4'5'6'7'8'9'10'11'12'13'14'15'16'17'-hexadecahydrospiro[13-benzodioxole-23'-cyclopenta[a]phenanthren]-17'-yl)pentanoateExperimental 3D Coordinates
researchProduct

Evaluation of Fused Pyrrolothiazole Systems as Correctors of Mutant CFTR Protein.

2021

Cystic fibrosis (CF) is a genetic disease caused by mutations that impair the function of the CFTR chloride channel. The most frequent mutation, F508del, causes misfolding and premature degradation of CFTR protein. This defect can be overcome with pharmacological agents named “correctors”. So far, at least three different classes of correctors have been identified based on the additive/synergistic effects that are obtained when compounds of different classes are combined together. The development of class 2 correctors has lagged behind that of compounds belonging to the other classes. It was shown that the efficacy of the prototypical class 2 corrector, the bithiazole corr-4a, could be impr…

Yellow fluorescent proteinProtein FoldingCystic FibrosisMutantPharmaceutical ScienceCystic Fibrosis Transmembrane Conductance RegulatorCarboxamidemedicine.disease_cause01 natural sciencesAnalytical Chemistrychemistry.chemical_compoundMutant ProteinDrug DiscoveryMoietyCFTR potentiatorCFTRchemistry.chemical_classification0303 health sciencesMutationbiologyChemistryChemistry (miscellaneous)Chloride channelMolecular MedicineHumanStereochemistrymedicine.drug_classCFTR correctorArticleF508del-CFTRlcsh:QD241-44103 medical and health scienceslcsh:Organic chemistrymedicineHumansBenzodioxolesPhysical and Theoretical ChemistryThiazoleCystic Fibrosi030304 developmental biology010405 organic chemistryOrganic ChemistryAminoimidazole Carboxamide0104 chemical sciencesThiazolesMutationbiology.proteinMutant ProteinsBenzodioxoleTricyclicMolecules (Basel, Switzerland)
researchProduct