Search results for "Bethesda"
showing 9 items of 9 documents
Thyroid neoplasms: surgical and cyto-histopathological connections on a six year cases study
2018
This study aims to evaluate the percentage of cyto-histologic correlation in patients with a thyroid disease documented through clinical-instrumental, cytological (FNAB), histological and surgical examinations. The purpose of this study is also to determine the percentage of disease incidence and evaluating any surgical indication in relation to biological behavior (benign, malignant or indeterminate lesions, occult carcinomas), sex, and age.Almost all of thyroid neoplasms is manifested through thyroid nodule. Therefore, clinical evidence of the thyroid nodule analysis is primarily related to the need to exclude malignant pathology or carcinoma of the thyroid, present in 4-6.5% of cases.The…
Improving Diagnostic Performance for Thyroid Nodules Classified as Bethesda Category III or IV: How and by Whom Ultrasonography Should be Performed
2020
Background: The purpose of this prospective study is to evaluate if the association of Bethesda system and a 3-categories Ultrasonography (US) risk stratification system proposed by the American Association of Clinical Endocrinologists/American College of Endocrinology/Associazione Medici Endocrinologi improves the performance of cytology alone in III or IV categories and if further variables such as US provider (radiologist; endocrinologist, or endocrine surgeon both coming from a dedicated team) influence the accuracy of the diagnostic. Methods: 570 consecutive patients with complete clinical records, affected by Bethesda III or IV nodules, have been addressed to two public referral surgi…
Vairogdziedzera mezglu analizēšana, izmantojot attēlu diagnostikas klasifikācijas un datu sistēmu (TIRADS), un salīdzinot ar Bethesda sistēmu
2017
Vairogdziedzera attēlu diagnostikas klasifikācijas un datu sistēma (Thyroid Imaging Reporting and Data System, TIRADS) ir klasifikācijas sistēma, kas iedala mezglu malignitātes riskus. Katra kategorija reprezentē vairogdziedzera mezgla malignitātes risku. Tā izveidota ar mērķi uzlabot reaģēšanu un izmaksu pārvaldību, samazinot vajadzību pēc ar tievu adatu aspirācijas biopsijas pacientiem, kuriem ir vairogdziedzera mezgli. TIRADS sistēma ir riska novērtēšanas sistēma vairogdziedzera audu bojājumu klasificēšanai. TIRADS novērtējums sniedz informāciju par vairogdziedzera struktūru, malignitātes risku un klasifikāciju. Bethesda sistēma vairogdziedzera citopatoloģiju novērtēšanai ir vairogdziedz…
Vairogdziedzera mezglu malignitātes riska standartizēto novērtēšanas sistēmu salīdzinājums
2020
Vairogdziedzera mezglu malignitātes riska standartizētas novērtēšanas sistēmas (TIRADS) vairogdziedzera ultrasonogrāfijas laikā ir ļoti svarīgas pacientiem ar vairogdziedzera mezgliem, jo tās var palīdzēt izvērtēt tievās adatas aspirācijas biopsijas (FNA) nepieciešamību. Pasaulē ir izveidotas vairākas TIRADS novērtēšanas sistēmas, Latvijā tiek pielietota Kwak et al. 2011. gadā izveidota TIRADS sistēma, tomēr neviena no TIRADS sistēmām nav atzīta par etalonu. Pētījuma mērķis ir izpētīt, kura no trim TIRADS sistēmām ir jutīgāka un precīzāka – Latvijā pielietojamā, Eiropas vai Korejas TIRADS sistēma. Materiāli un metodes: Prospektīvs pētījums, kurā tika analizēti 176 pacientu vairogdziedzeru u…
Factor VIII products and inhibitor development in severe hemophilia A
2013
For previously untreated children with severe hemophilia A, it is unclear whether the type of factor VIII product administered and switching among products are associated with the development of clinically relevant inhibitory antibodies (inhibitor development). We evaluated 574 consecutive patients with severe hemophilia A (factor VIII activity, <0.01 IU per milliliter) who were born between 2000 and 2010 and collected data on all clotting-factor administration for up to 75 exposure days. The primary outcome was inhibitor development, which was defined as at least two positive inhibitor tests with decreased in vivo recovery of factor VIII levels. Inhibitory antibodies developed in 177 of th…
Impact of the Hypoechogenicity Criteria on Thyroid Nodule Malignancy Risk Stratification Performance by Different TIRADS Systems
2021
Background: Various Thyroid Imaging and Reporting data systems (TIRADS) are used worldwide for risk stratification of thyroid nodules. Their sensitivity is high, while the specificity is suboptimal. The aim of the study was to compare several TIRADS systems and evaluate the effect of hypoechogenicity as a sign of risk of malignancy on the overall assessment of diagnostic accuracy. Methods: The prospective study includes 274 patients with 289 thyroid nodules to whom US and risk of malignancy were assessed according to four TIRADS systems—European (EU-TIRADS), Korean (K-TIRADS), TIRADS by American College of Radiology (ACR TIRADS), and modified Kwak et al. TIRADS (L-TIRADS) systems, in which …
Atypical squamous cells of undetermined significance-favour reactive compared to atypical squamous cells of undetermined significance-favour dysplasi…
2005
Abstract Background and objectives: The current study compared the cervical cytological sub-category “atypical squamous cells of undetermined significance-favour reactive (AFR)”, recently recommended to be eliminated by the Bethesda system, to the sub-category “atypical squamous cells of undetermined significance-favour dysplasia (ASC-US)”, in terms of prevalence of coexistent squamous intraepithelial lesions of either low-grade (LSIL) or high-grade (HSIL) and rate of human papillomavirus (HPV) infection. Study design: One hundred women with AFR and 100 with ASC-US were consecutively included in the study. All patients underwent colposcopy, followed by biopsy when necessary, and were screen…
Idiopathic thrombotic thrombocytopenic purpura: strongest risk factor for relapse from remission is having had a relapse
2016
BACKGROUND Thrombotic thrombocytopenic purpura (TTP) is a rare, episodic clinical syndrome involving the production of thrombi in the microvasculature accompanied by thrombocytopenia and symptoms of organ ischemia. Idiopathic TTP develops when a patient produces antibodies that react with the protease ADAMTS13. The course after an episode is unpredictable; patients may relapse frequently or never. There is no laboratory value that can reliably predict potential relapse. STUDY DESIGN AND METHODS To assess diagnostic and predictive values for risk of relapse, plasma samples from 27 patients with idiopathic TTP in remission were analyzed for anti-ADAMTS13 immunoglobulin (Ig)G, ADAMTS13 activit…
Predictors of Central Compartment Involvement in Patients with Positive Lateral Cervical Lymph Nodes According to Clinical and/or Ultrasound Evaluati…
2021
Lymph node neck metastases are frequent in papillary thyroid carcinoma (PTC). Current guidelines state, on a weak level of evidence, that level VI dissection is mandatory in the presence of latero-cervical metastases. The aim of our study is to evaluate predictive factors for the absence of level VI involvement despite the presence of metastases to the lateral cervical stations in PTC. Eighty-eight patients operated for PTC with level II–V metastases were retrospectively enrolled in the study. Demographics, thyroid function, autoimmunity, nodule size and site, cancer variant, multifocality, Bethesda and EU-TIRADS, number of central and lateral lymph nodes removed, number of positive lymph n…