Search results for "Bile"
showing 10 items of 2148 documents
IL DOPPIO PROCESSO A FINALITA' RISARCITORIA DEL DANNO ERARIALE TRA LE SENTENZA DELLA CORTE EDU 'RIGOLIO' ED IL CODICE DELLA GIUSTIZIA CONTABILE
2017
II contributo esamina il tema della giurisdizione sul danno alla pubblica amministrazione nel caso di doppio processo a finalità risarcitoria del danno erariale, traendo spunto dalla sentenza della Corte EDU 'Rigolio' (13 maggio 2014, su ricorso n. 20148/09) ed anche alla luce della recente entrata in vigore del d.lgs. 26 agosto 2016, n. 174, con il quale e stato approvato il «Codice di giustizia contabile» ai sensi dell'articolo 20 della legge 7 agosto 2015, n.124. Nonostante la delega legislativa indicasse esplicitamente quale obiettivo principale «la concentrazione delle tutele spettanti alla cognizione della giurisdizione contabile», alla successiva attuazione non può, tuttavia, attribu…
COVID-19: dalle indicazioni ministeriali per la fase 2 alla nuova visione di odontoiatria sicura, sostenibile e centrata sul paziente
2020
La pandemia COVID-19, originaria di Wuhan in Cina, è diventata una grande sfida per la salute pubblica globale, modificando radicalmente la vita di tutti i giorni e le attività lavorative, specialmente quelle di ambito sanitario tra cui l’attività odontoiatrica. È stato necessario attuare delle misure di controllo delle infezioni per prevenire ulteriori diffusioni del virus. L’alto livello di attenzione che si è riusciti a raggiungere nella fase acuta della pandemia stessa ha determinato un efficiente bio-contenimento. Si impone, sin dalla fase 2, un ragionato e idoneo adeguamento di protocolli operativi di prevenzione e protezione. Prudenza, perizia e diligenza devono essere i punti cardin…
TCP Performance in Mobile Ad hoc Networks
2013
International audience; In this paper, we present a survey of TCP (Transmission Control Protocol) protocol for better performance in the MANET (Mobile Ad Hoc Network). After a short presentation of the main features of TCP, we give the most important problems from which TCP suffer in MANET. We present after that some approaches proposed in the literature in order to improve its performance. Our paper contains also a performance evaluation of TCP NewReno and TCP Vegas transport protocols under AODV and DSR routing protocols. The simulations are conducted under varying conditions of number of TCP connections, number of nodes and mobility.
Architetture rupestri a Caltabellotta
2020
Questo saggio descrivere i caratteri tipologici, le evoluzioni nel tempo e le connotazioni costruttive dell'architettura rupestre a Caltabellotta (AG). L’Italia rupestre, nella sua totalità, può – e non a torto - essere considerata un plusvalore se non ancora del tutto da scoprire, sicuramente da valorizzare e re-interpretare nel progetto di architettura e fruizione dei beni culturali e paesaggistici; non a caso, sovente le aree rupestri rappresentano un sistema attrattivo oggetto di tutela, inserito in piani paesistici e protetto da un vincolo di riserva naturale in ambito regionale, o ancora inserito in istituiti o istituendi distretti turistici. Il saggio ha analizzato cavità artificiali…
Socioeconomic Environment and Survival in Patients with Digestive Cancers: A French Population-Based Study
2021
Simple Summary Studies investigating the social gradient in digestive cancer survival are scarce, and the statistical methods used do not always consider important assumptions in survival analysis for adequate assessment. Using an ecological index (European Deprivation Index), we found a negative impact of social environment in digestive cancers net survival (especially for esophagus, stomach, bile ducts among females; colon and rectum for both sexes) and provided insight into how this social gradient in cancer survival builds up, and at what time of follow-up it appears. These results can guide clinical practice/public health actions to address social inequalities in survival by targeting …
Role of the Ha-ras gene in the malignant transformation of rat liver oval cells.
1997
We have shown that the oval cell line OCICDE 22 can be transformed by the highly carcinogenic fiord-region diol epoxides of benzo[c]phenanthrene. Mutational activation of the ras proto-oncogene family has been proposed to be a critical event in the formation of tumors induced by polycyclic aromatic hydrocarbons. Therefore, we investigated whether in the earlier transformed OCICDE 22 cells any point mutations were detected in the ras proto-oncogene. The results indicate that the malignant transformation of OCICDE 22 cells by the 4 stereoisomeric benzo[c]phenan-threne diol epoxides in vitro is independent of activation of the Ha-ras proto-oncogene. In addition, Northern and Western blot analy…
FOENIX-101: A phase II trial of TAS-120 in patients with intrahepatic cholangiocarcinoma harboring FGFR2 gene rearrangements.
2019
TPS468 Background: Intrahepatic cholangiocarcinoma (iCCA) is a cancer arising from the intrahepatic bile duct. Standard treatment of unresectable, recurrent, or metastatic iCCA is with cytotoxic chemotherapy. FGFR2 gene fusions have been identified as oncogenic drivers in 10–20% of iCCA tumors, but no targeted agents have been established to date. TAS-120 is an investigational irreversible FGFR1–4 inhibitor in development as a once-daily oral treatment for iCCA. Based on initial studies in multiple tumor types expressing FGFR abnormalities, iCCA was identified as a tumor type with potential susceptibility to FGFR inhibition and high unmet need. A phase I portion of the trial with an iCCA e…
On the spectral moments of non-WSSUS mobile-to mobile double-Rayleigh fading channels
2017
This paper deals with the mathematical analysis of the spectral moments of non-wide-sensestationary uncorrelated-scattering (non-WSSUS) mobile-to-mobile (M2M) double-Rayleigh fading channels. The point of departure is a recently proposed geometry-based statistical model (GBSM) for M2M double-Rayleigh fading channels from which general analytical expressions are derived for the average Doppler shift, Doppler spread, average delay, and delay spread. Closed-form solutions of such expressions are presented for the particular case of the geometrical two-rings scattering model. The obtained results indicate that the average Doppler shift and Doppler spread are directly influenced by not only the …
Bile acid-derived mono- and diketals—synthesis, structural characterization and self-assembling properties
2010
Three oxo-derivatives of bile acid methyl esters have been used as starting compounds in the preparation of novel bile acid monoketals with 1,2-benzenediol (catechol) and 2,3-naphthalenediol, as well as mono- and diketals with pentaerythritol. Monoketals of pentaerythritol showed a tendency to form thermoreversible gels in many aromatic solvents and the methyl lithocholate derivative proved to be a supergelator able to form a gel with t-butylbenzene at a concentration as low as 0.5% w/v. Whereas the naphthalenediol ketals formed film-type materials in the studied solvents, the catechol ketals underwent rapid crystallization into X-ray quality single crystals. Single crystal X-ray structures…
Miłosierdzie jako istotna kategoria pedagogiki katolickiej
2017
Mercy - an important category of Catholic pedagogy God is the One who is present, close, holy, and merciful. An important task of every Christian is to recognise the merciful look of Jesus Christ. He is the only hope for sinful people. Mercy is the bridge that connects God and man, opening our hearts to the hope of being loved forever despite our sinfulness. Mercy is the fundamental idea of Catholic pedagogy: every Christian is called to show mercy because mercy has first been shown to him. Pardoning offences becomes the clearest expression of merciful love, and for the Christians it is an imperative from which we cannot excuse oursełves. Jesus made mercy an ideał of life and a criterion fo…