Search results for "Bile"

Zvaigžņotā Debess: 2015, Rudens (229)

2015

Latvijas Universitāte

Genome-Wide Association Analysis in Primary Sclerosing Cholangitis

2010

Background & Aims We aimed to characterize the genetic susceptibility to primary sclerosing cholangitis (PSC) by means of a genome-wide association analysis of single nucleotide polymorphism (SNP) markers. Methods A total of 443,816 SNPs on the Affymetrix SNP Array 5.0 (Affymetrix, Santa Clara, CA) were genotyped in 285 Norwegian PSC patients and 298 healthy controls. Associations detected in this discovery panel were re-examined in independent case-control panels from Scandinavia (137 PSC cases and 368 controls), Belgium/The Netherlands (229 PSC cases and 735 controls), and Germany (400 cases and 1832 controls). Results The strongest associations were detected near HLA-B at chromosome 6p21…

Opportunistic traffic Offloading Mechanisms for Mobile/4G Networks

2015

A 'gateway city' between landscape and cultural heritage

2015

The paper analyzes the achievable strategic role that the porto of Porto Empedocle (sinergy by Agrigento, its "city mother") could have. This marginal city, localized in the center of the African side of the Sicily, is far from European politics, but this situation could change. It's necessary to improve the sea routes and to activate the disused railway line from Porto Empedocle to Castelvetrano (near Trapani). This solution will help the accessibility of Agrigento and the development of the little coastal towns organized in a slow and sustainable network. Lo scritto analizza il possibile ruolo strategico che il porto di Porto Empedocle (in sinergica con la sua città-madre, Agrigento). Que…

Implementation of laser speckle contrast analysis as connection kit for mobile phone for assessment of skin blood flow

2014

Laser speckle contrast analysis (LASCA) offers a non-contact, full-field, and real-time mapping of capillary blood flow and can be considered as an alternative method to Laser Doppler perfusion imaging. LASCA technique has been implemented in several commercial instruments. However, these systems are still too expensive and bulky to be widely available. Several optical techniques have found new implementations as connection kits for mobile phones thus offering low cost screening devices. In this work we demonstrate simple implementation of LASCA imaging technique as connection kit for mobile phone for primary low-cost assessment of skin blood flow. Stabilized 650 nm and 532 nm laser diode m…

In vivo confocal laser laparoscopy allows real time subsurface microscopy in animal models of liver disease.

2007

Background/Aims Histopathology is essential in the diagnostic workup of most liver diseases. However, biopsy sampling might carry risks, is subject to sampling error, and does not provide dynamic tissue imaging. Therefore a newly developed miniaturised confocal probe was evaluated for in vivo microscopic imaging in rodent models of human liver diseases. Methods The handheld laparoscopy probe used a 488nm single line laser for fluorophore excitation. Optical slice thickness was 7μm, lateral resolution 0.7μm. Imaging depth was 0–250μm below the tissue surface. Imaging using different fluorescent staining protocols was performed in healthy mice, IFNγ- and IL-12-induced hepatitis, after bile du…

Liposome Formation from Bile Salt–Lipid Micelles in the Digestion and Drug Delivery Model FaSSIFmod Estimated by Combined Time-Resolved Neutron and D…

2011

The flow of bile secretion into the human digestive system was simulated by the dilution of a bile salt-lipid micellar solution. The structural development upon the dilution of the fed state bile model FeSSIF(mod6.5) to the fasted state bile model FaSSIF(mod) was investigated by small-angle neutron scattering (SANS) and dynamic light scattering (DLS) in crossed beam experiments to observe small and large structures in a size range of 1 nm to 50 μm in parallel. Because of the physiologically low lipid and surfactant concentrations of 2.625 mM egg-phosphatidylcholine and 10.5 mM taurocholate the sensitivity of the neutron-structural investigations was improved by partial solvent deuteration w…

A Lipopolysaccharide Antigen of the Treponema

1958

IMMUNOCHEMICAL studies carried out by D'Alessandro et al. 1 on a non-pathogenic, culturable treponeme, the so-called Reiter treponeme, revealed the presence of four antigenic components: (1) a thermolabile protein; (2) a specific, thermostable antigen with polysaccharide characteristics; (3) a lipoid, corresponding to the ubiquitous lipidic antigen cardiolipin; (4) another lipoid similar to the organ-specific cerebral antigen of Witebsky2. These studies led to the conclusion that the treponemes, like other organisms, are mosaics of antigens, and a safe basis was established for a better understanding of the complex serological response of the infected host.

Plasma PLTP (phospholipid-transfer protein): an emerging role in ‘reverse lipopolysaccharide transport’ and innate immunity

2011

Plasma PLTP (phospholipid-transfer protein) is a member of the lipid transfer/LBP [LPS (lipopolysaccharide)-binding protein] family, which constitutes a superfamily of genes together with the short and long PLUNC (palate, lung and nasal epithelium clone) proteins. Although PLTP was studied initially for its involvement in the metabolism of HDL (high-density lipoproteins) and reverse cholesterol transport (i.e. the metabolic pathway through which cholesterol excess can be transported from peripheral tissues back to the liver for excretion in the bile), it displays a number of additional biological properties. In particular, PLTP can modulate the lipoprotein association and metabolism of LPS …

Ensuring Sufficient Literacy Practice with Tablet Technology in Zambian Schools

2015

Tablets are a promising mobile device for disseminating e-Learning materials at schools in Africa. E-learning materials can be especially useful for the practice of early literacy skills. Introducing mobile devices to schools can be challenging as teachers are required to make changes to their daily routines and the use of technology can be problematic in overcrowded classrooms. This study aimed to find out the most optimal way of providing GraphoGame literacy intervention via tablets for grade one learners in an urban school environment. The study tested whether GraphoGame mounted on tablets increases initial literacy skills among grade one learners. Three different conditions for providin…