Search results for "Bile"

Youngtimers : a sociology of contemporary relations to oldcars

2022

If this was not still the case 50 years ago, the automobile is today an essential capital good for a majority of French households. For a majority of individuals, and in a context of increasing urbanization, mobility is in fact essential for individuals who have to move here for their work, there for their leisure, or even to multiple places of consumption or sociability. . Everywhere, in cities as in the countryside, the automobile has established itself as the main mode of daily transport. The generalization of car ownership has thus modified the way of life of individuals as well as all the stages of professional and family life, and to put it simply, contemporary urban society presuppos…

Governare la mobilità condivisa nella città con- temporanea: limiti e possibilità per le politiche pubbliche

2023

Il saggio si propone di analizzare alcune conseguenze che la diffusione della mobilità condivisa comporta nella città contemporanea, identificando alcuni nodi per le politiche pubbliche che andrebbero poste in agenda dai policy makers nazionali e locali. Il testo in primis descrive le condizioni che hanno consentito la diffusione della sharing mobility nelle città occidentali, sottolineandone il peculiare rapporto che tali servizi instaurano con l’ambiente costruito rispetto ai sistemi di tra- sporto convenzionali. Successivamente viene offerta una sintetica descrizione dello stato dell’arte della mobilità condivisa nel nostro paese, nel più ampio contesto del cambiamento delle città sul pi…

Agenda urbana delle città della Sicilia Occidentale: la greenway costiera come strumento di coesione a valorizzazione territoriale

2017

Nell’ambito dell’Agenda urbana regionale della Sicilia per il ciclo di programmazione 2014-2020, le principali cinque città di tale sistema hanno deciso di intraprendere un per- corso progettuale comune che le condurrà alla redazione di una Strategia di Sviluppo Urbano Sostenibile ispirata da tre obiettivi cardine: il rafforzamento della coesione territoriale, l’incremento dell’accessibilità alle risorse territoriali, un miglioramento complessivo dell’offerta di servizi locali. Un elemento connettivo della strategia rispetto ai tre obiettivi sopra delineati è la progettazione di una ciclovia che accresca le relazioni di sinergia tra le città e tra esse e le risorse territoriali diffuse, sec…

IL SISTEMA TRANVIARIO E LA MOBILITÀ SOSTENIBILE: IL CASO DEI PARCHI

2008

La pianificazione e la gestione di un sistema infrastrutturale di trasporto si fonda sulla conoscenza della domanda di mobilità, delle condizioni socio-economiche del bacino d’utenza, delle peculiarità ambientali del contesto di inserimento e di molteplici altri fattori. La complessità delle scelte progettuali per il governo del sistema di trasporto pubblico si acuisce notevolmente per realtà territoriali con limitata concentrazione insediativa come, ad esempio, le aree protette ed, ancor di più, i parchi. L’esigenza di promozione e sviluppo di queste aree, spesso contraddistinte da superfici estese in ambito sovracomunale, contrasta con la necessità di tutelare l’inestimabile patrimonio na…

LynxNet: Wild Animal Monitoring Using Sensor Networks

2010

Monitoring wild animals, especially those that are becoming endangered (for example, lynxes and wolves) is important for biology researchers. Solutions for the monitoring already exist; however, they all have drawbacks, such as limited range or lifetime, sensing modality, reporting delays, unreliability of operation. In this work we describe our experiences in designing an improved animal monitoring sensor system and low-level software for sensor node control and communication. The target animals for this particular research are wild lynxes or canines, however it can be extended to other animal species. The LynxNet system is based on tracking collars, built around TMote Mini sensor nodes, s…

Reengineering an Approach to Model-Driven Development of Business Apps

2015

Despite a perceived convergence in mobile application development, platforms such as Android and iOS remain largely incompatible. Supporting multiple platforms currently requires either separate native development (for each system) or utilization of a cross-platform development framework. While many such frameworks have been developed, only few are mature and even less are used widely, let alone commercially. Moreover, they typically are limited with regard to performance and to preserving a native look & feel. Worst of all, their usefulness for business apps is limited due to their low level of abstraction. In this paper, we take a closer look at an academic prototype that employs model-dr…

Modeling and Simulation of Mobile Radio Channels

2012

Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm

2020

We have previously shown that the thermolabile, cavity-creating p53 cancer mutant Y220C can be reactivated by small-molecule stabilizers. In our ongoing efforts to unearth druggable variants of the p53 mutome, we have now analyzed the effects of other cancer-associated mutations at codon 220 on the structure, stability, and dynamics of the p53 DNA-binding domain (DBD). We found that the oncogenic Y220H, Y220N, and Y220S mutations are also highly destabilizing, suggesting that they are largely unfolded under physiological conditions. A high-resolution crystal structure of the Y220S mutant DBD revealed a mutation-induced surface crevice similar to that of Y220C, whereas the corresponding pock…

Picomolar inhibition of cholera toxin by a pentavalent ganglioside GM1os-calix[5]arene

2013

Cholera toxin (CT), the causative agent of cholera, displays a pentavalent binding domain that targets the oligosaccharide of ganglioside GM1 (GM1os) on the periphery of human abdominal epithelial cells. Here, we report the first GM1os-based CT inhibitor that matches the valency of the CT binding domain (CTB). This pentavalent inhibitor contains five GM1os moieties linked to a calix[5]arene scaffold. When evaluated by an inhibition assay, it achieved a picomolar inhibition potency (IC50 = 450 pM) for CTB. This represents a significant multivalency effect, with a relative inhibitory potency of 100000 compared to a monovalent GM1os derivative, making GM1os-calix[5]arene one of the most potent…

Biocompatible Hydrogelators Based on Bile Acid Ethyl Amides

2016

Four novel bile acid ethyl amides were synthetized using a well-known method. All the four compounds were characterized by IR, SEM, and X-ray crystal analyses. In addition, the cytotoxicity of the compounds was tested. Two of the prepared compounds formed organogels. Lithocholic acid derivative 1 formed hydrogels as 1% and 2% (w/v) in four different aqueous solutions. This is very intriguing regarding possible uses in biomedicine. peerReviewed