Biocompatible Hydrogelators Based on Bile Acid Ethyl Amides

6533b853fe1ef96bd12ad551

RESEARCH PRODUCT

Biocompatible Hydrogelators Based on Bile Acid Ethyl Amides

Roosa-maria Willman Rakesh Puttreddy Jitka Ulrichová Hannu Salo Elina I. Sievänen Adéla Galandáková Riikka Kuosmanen Kari Rissanen Ilkka ÄIjäläinen

subject

Models Molecular Lithocholic acid Biocompatibility medicine.drug_class Clinical Biochemistry supramolecular hydrogel Molecular Conformation Biocompatible Materials 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry Mice chemistry.chemical_compound Endocrinology biocompatibility Amide medicine Animals Organic chemistry bile acid Molecular Biology ta116 Pharmacology Aqueous solution Bile acid Organic Chemistry ta1182 Water Hydrogels 3T3 Cells self-assembly 021001 nanoscience & nanotechnology Amides amide 0104 chemical sciences chemistry Biochemistry Self-healing hydrogels Lithocholic Acid Self-assembly 0210 nano-technology Derivative (chemistry)

description

Four novel bile acid ethyl amides were synthetized using a well-known method. All the four compounds were characterized by IR, SEM, and X-ray crystal analyses. In addition, the cytotoxicity of the compounds was tested. Two of the prepared compounds formed organogels. Lithocholic acid derivative 1 formed hydrogels as 1% and 2% (w/v) in four different aqueous solutions. This is very intriguing regarding possible uses in biomedicine. peerReviewed

year	journal	country	edition	language
2016-01-01

http://urn.fi/URN:NBN:fi:jyu-201604112041

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