Search results for "Biomarqueur"
showing 6 items of 16 documents
Association of a predictor of retinal omega-3 polyunsaturated fatty acids with advanced age-related macular degeneration: the BLISAR project
2019
International audience
HSP70-exosomes for the monitoring of cancer
2020
Actually, cancer is unfortunately part of our daily life. Although it is better treated, more and more people are affected. Cancer research is working on two side: therapy and diagnosis. The next-generation therapies show wonderful results that were never reached so far, but diagnosis improvement can also save lives. It is well established that the earlier the cancer is diagnosed, the better the survival rate. Idem for the follow-up of the disease. In this context of precision and earliness, liquid biopsy spark interest and seems to have a bright future. It consists in the investigation of liquid analytes, particularly within the bloodstream, such as circulating tumor DNA, circulating tumor…
DIAGSOL : development of a new functional marker of exposure to herbicides B-triketones in an agricultural soil
2020
Numerous herbicides target an enzyme found not only in weeds but also in « non-target organisms » such as microorganisms. This proof-of-concept study aims to use microbial gene encoding the targeted enzyme or the targeted enzyme itself as a marker for herbicide exposure in soils. The hppd gene and the encoded enzyme (HPPD; 4-hydroxyphenylpyruvate dioxygenase), targeted by B-triketone herbicides, are the subject of this study. In silico analyses reveal that the hppd gene is spread out in all bacterial phyla. Primers specific to this gene were designed. This primer pair is used to measure the abundance, the composition and the diversity of the hppd bacterial community in soil microcosms expos…
DIAGSOL : Développement d’un outil microbien pour évaluer l’exposition des sols agricoles aux herbicides β-tricétones
2018
International audience; En 2011, en France, plus de 2 millions d’hectares de champs de maïs ont été traités avec desherbicides β-tricétones. Qualifiés de « respectueux de l’environnement » en raison d’une efficacité àfaible dose, de récentes études ont démontré un effet transitoire des β-tricétones sur la diversitébactérienne des sols (Romdhane et al., 2016). L’utilisation récurrente des β-tricétones pourrait, àterme, perturber la diversité bactérienne et les fonctions écosystémiques des sols qu’elle soutient.Il est essentiel d’évaluer l’exposition des microorganismes des sols aux β-tricétones.L’enzyme 4-hydroxyphénylpyruvate dioxygénase (4-HPPD), cible de ces herbicides chez les plantesadv…
Role of biomarkers in the management of antibiotic therapy : an expert panel review : I - currently available biomarkers for clinical use in acute in…
2013
Abstract In the context of worldwide increasing antimicrobial resistance, good antimicrobial prescribing in more needed than ever; unfortunately, information available to clinicians often are insufficient to rely on. Biomarkers might provide help for decision-making and improve antibiotic management. The purpose of this expert panel review was to examine currently available literature on the potential role of biomarkers to improve antimicrobial prescribing, by answering three questions: 1) Which are the biomarkers available for this purpose?; 2) What is their potential role in the initiation of antibiotic therapy?; and 3) What is their role in the decision to stop antibiotic therapy? To ans…
Sur la piste des matériaux organiques grâce à la spectrométrie de masse
2018
Identifying the organic materials present, establishing their origin and degree of preservation, understanding their manufacturing process and their use, all of which require interdisciplinary studies involving closely specialists in materials and human sciences. In this very specific context, mass spectrometry has become a key tool to improve knowledge of past civilizations but also to better preserve and restore the discrete remains of archaeomaterials. The identification of diagnostic molecular markers of natural substances is now a recognized strategy for characterizing amorphous organic materials (fats, beeswaxes, vegetable substances such as resins and tars). New advances have also ma…