Search results for "Biomedical"
showing 10 items of 2328 documents
Surgical clinical trials—need for international collaboration
2013
End-user Need based Creation of a Medical Device: An Experience of Co-design to Struggle Pathological Scars
2020
International audience; Scar is a common visible mark of human tissue healing. Sometimes pathological phenomena lead to abnormal hypertrophic or keloid scars, with evolutions varying depending on different conditions: origin of the tissue barrier disruption, concerned body area, or ethnic origin. Based on these statements, care procedures have been developed to avoid aesthetical or functional impairments: drugs injection, surgery, cryotherapy or mechanical compression. The story will relate the matching of a multi-disciplinary team that focused on covering an unmet need for ear lobe keloid treatment, providing patients an optimal and holistic care. The benefits researched lied in improving …
New ECCO model documents for Material Deposit and Transfer Agreements in compliance with the Nagoya Protocol
2020
The European Culture Collections Organisation presents two new model documents for Material Deposit Agreement (MDA) and Material Transfer Agreement (MTA) designed to enable microbial culture collection leaders to draft appropriate agreement documents for, respectively, deposit and supply of materials from a public collection. These tools provide guidance to collections seeking to draft an MDA and MTA, and are available in open access to be used, modified, and shared. The MDA model consists of a set of core fields typically included in a deposit form to collect relevant information to facilitate assessment of the status of the material under access and benefit sharing (ABS) legislation. It a…
How to integrate dreaming into a general theory of consciousness—A critical review of existing positions and suggestions for future research
2011
In this paper, we address the different ways in which dream research can contribute to interdisciplinary consciousness research. As a second global state of consciousness aside from wakefulness, dreaming is an important contrast condition for theories of waking consciousness. However, programmatic suggestions for integrating dreaming into broader theories of consciousness, for instance by regarding dreams as a model system of standard or pathological wake states, have not yielded straightforward results. We review existing proposals for using dreaming as a model system, taking into account concerns about the concept of modeling and the adequacy and practical feasibility of dreaming as a mod…
Collecting large cohorts of patients with uncommon diseases: mission impossible?
2007
Full‐thickness tissue engineered oral mucosa for genitourinary reconstruction: A comparison of different collagen‐based biodegradable membranes
2020
Tissue engineering is a method of growing importance regarding clinical application in the genitourinary region. One of the key factors in successfully development of an artificially tissue engineered mucosa equivalent (TEOM) is the optimal choice of the scaffold. Collagen scaffolds are regarded as gold standard in dermal tissue reconstruction. Four distinct collagen scaffolds were evaluated for the ability to support the development of an organotypical tissue architecture. TEOMs were established by seeding cocultures of primary oral epithelial cells and fibroblasts on four distinct collagen membranes. Cell viability was assessed by MTT-assay. The 3D architecture and functionality of the ti…
Integration of Metal Organic Chemical Vapour Deposition and Wet Chemical Techniques to Obtain Highly Ordered Porous ZnO Nanoplatforms
2011
Large-area, highly ordered ZnO micropores-arrays consisting of ZnO nanotubes delimited by ZnO nanorods have been successfully fabricated and tested for protein sensing applications. ZnO seed layers have been deposited by Metal Organic Chemical Vapour Deposition and readily patterned by Colloidal Lithography to attain ZnO nanorods growth at selective sites by Chemical Bath Deposition. The used synthetic approach has been proven effective for the easy assembly of ZnO nanoplatforms into high-density arrays. Both patterned and unpatterned ZnO nanorods have been morphologically and compositionally characterised and, thus, tested for model studies of protein mobility at the interface. The pattern…
Metamodelling architectures for complex data integration in systems biology
2010
Systems biology aims at deciphering the functioning of biological systems on the basis of the knowledge of their molecular components and the relations between such components. To address the issues involved, high-throughput technologies are used. Taking advantage of the standards that are being currently developed to achieve consensual representations of technological domains, we present a metamodelling architecture based on these standards. The proposed architecture organises standard-specific metamodels and models into a single hierarchy. Each metamodel describes a consensus that is shared by several models of applications. A metamodel construct for description of faceted element is prop…
Are there any differences in various polyaxial locking systems? A mechanical study of different locking screws in multidirectional angular stable dis…
2012
Numerous angular stable plates for the distal radius exist, and technically based comparisons of the polyaxial locking interfaces are lacking. The aim of this mechanical study was to investigate three different locking interfaces of angular stable volar plates by cantilever bending: VA-LCP Two-Column Distal Radius Plates 2.4 mm (Synthes® GmbH, Oberdorf, Switzerland), IXOS® P4 (Martin, Tuttlingen, Germany) and VariAX™ (Stryker®, Duisburg, Germany). We assessed the strength of 0°, 5°, 10° and 15° screw locking angles and tested the bending strength from 10° to 5° angles by cyclic loading until breakage. The final setup repeated the above assessments by inclusion of four locking screws. The si…
Towards High Resolution Computational Models of the Cardiac Conduction System: A Pipeline for Characterization of Purkinje-Ventricular-Junctions
2011
The cardiac conduction system (CCS) has been in the spot light of the clinical and modeling community in recent years because of its fundament role in physiology and pathophysiology of the heart. Experimental research has focused mainly on investigating the electrical properties of the Purkinje-ventricular-junctions (PVJs). The structure of the PVJs has only been described through schematic drawings but not thoroughly studied. In this work confocal microscopy was used with the aim of three-dimensional characterization of PVJs. Adult rabbit hearts were labeled with fluorescent dyes, imaged with confocal microscopy and Purkinje fibers differentiated from other cardiac tissue by their lack of …