Search results for "Biomolecules"
showing 10 items of 549 documents
Ab initio determination of the electron affinities of DNA and RNA nucleobases
2008
High-level quantum-chemical ab initio coupled-cluster and multiconfigurational perturbation methods have been used to compute the vertical and adiabatic electron affinities of the five canonical DNA and RNA nucleobases: uracil, thymine, cytosine, adenine, and guanine. The present results aim for the accurate determination of the intrinsic electron acceptor properties of the isolated nucleic acid bases as described by their electron affinities, establishing an overall set of theoretical reference values at a level not reported before and helping to rule out less reliable theoretical and experimental data and to calibrate theoretical strategies. Daniel.Roca@uv.es Manuela.Merchan@uv.es Luis.Se…
Interaction of iron(II)-heme and artemisinin with a peptide mimic of Plasmodium falciparum HRP-II
2007
Abstract The interaction of heme or heme-artemisinin adducts (heme-art) with different peptides mimicking repeat sequences of the Histidine-Rich-Protein-II of Plasmodium falciparum (PfHRP-II) was investigated. The pseudo-first order rate constants of the coordination of heme or heme-art onto a histidine rich peptide, used as a mimic of PfHRP-II putative heme binding sequence, are of the same order of magnitude, namely 42 and 14 s −1 , respectively. Despite the intrinsic reactivity of the carbonyl at C10 of heme-art toward a hydroxyl function, a peptide containing a serine or threonine residue does not readily react with heme-art adducts. Therefore, a much higher affinity of heme-art compare…
Vibrational modes of the stibine molecule
2005
International audience; In this paper, we use the algebraic approach to describe the vibrational modes of stibine molecule (of C3v molecular symmetry group) up to 21 quanta. As the stibine molecule exhibits stretch-bend resonances, we build an algebraic pyramidal coupling operator between stretching modes and bending modes adapted to this molecule. The standard deviation associated to the fit of the vibrational levels is 1.75 cm-1.
Non-equivalent hyperbolic knots
2002
We construct, for each integer n 3, pairs of non-equivalent hyperbolic knots with the same 2fold and n-fold cyclic branched covers. We also discuss necessary conditions for such pairs of knots to exist. 2001 Elsevier Science B.V. All rights reserved. MSC: primary 57M25; secondary 57M12, 57M50
Rapid inactivation and proteasome-mediated degradation of OGG1 contribute to the synergistic effect of hyperthermia on genotoxic treatments
2013
Inhibition of DNA repair has been proposed as a mechanism underlying heat-induced sensitization of tumour cells to some anticancer treatments. Base excision repair (BER) constitutes the main pathway for the repair of DNA lesions induced by oxidizing or alkylating agents. Here, we report that mild hyperthermia, without toxic consequences per se, affects cellular DNA glycosylase activities, thus impairing BER. Exposure of cells to mild hyperthermia leads to a rapid and selective inactivation of OGG1 (8-oxoguanine DNA glycosylase) associated with the relocalisation of the protein into a detergent-resistant cellular fraction. Following its inactivation, OGG1 is ubiquitinated and directed to pro…
"Table 24" of "Studies of quantum chromodynamics with the ALEPH detector"
1997
Unfolded values of the the mean multiplicity and dispersion of the multiplicity distribution integrated over the full rapidity region.
"Table 3" of "Measurement of the spin density matrix for the rho0, K*(892)0 and Phi produced in Z0 decays."
1997
Helicity density matrices elements. The statistical and systematic errors are combined quadratically.
"Table 18" of "Studies of quantum chromodynamics with the ALEPH detector"
1997
Unfolded charged particle multiplicity distribution giving the probability to have a hadronic Z0 decay with N charged particles.
"Table 6" of "Measurements of the charged particle multiplicity distribution in restricted rapidity intervals"
1995
Unfolded mean charged multiplicity distributions.
"Table 1" of "Measurements of the charged particle multiplicity distribution in restricted rapidity intervals"
1995
Unfolded charged particle multiplicity distribution given the probability to have an hadronic Z0 decay with MULT charged particles.