Search results for "Biophysic"
showing 10 items of 3565 documents
Analysis of motor control and behavior in multi agent systems by means of artificial neural networks
2004
Abstract This article gives a short introduction to Self-Organizing Maps, a particular form of Artificial Neural Networks and shows by some examples, how these approaches can be used in order to analyze and visualize time series data originating from complex systems. The methods shown in this article have originally been developed for the analysis of RoboCup robot soccer games, a special kind of so-called Multi Agent Systems. Although this application has no direct connection to biomechanics, the examples shown here may give an impression of the abilities of Neural Networks in the field of Time Series Analysis in general. Because of the abstractness of the methods, it appears to be very lik…
A neural network approach to movement pattern analysis.
2004
Movements are time-dependent processes and so can be modelled by time-series of coordinates: E.g., each articulation has geometric coordinates; the set of the coordinates of the relevant articulations build a high-dimensional configuration. These configurations--or "patterns"--give reason for analysing movements by means of neural networks: The Kohonen Feature Map (KFM) is a special type of neural network, which (after having been coined by training with appropriate pattern samples) is able to recognize single patterns as members of pattern clusters. This way, for example, the particular configurations of a given movement can be identified as belonging to respective configuration clusters, …
Double β Decay and the Axial Strength
2019
Quenching of the weak axial strength gA is discussed and relations of this quenching to the nuclear matrix elements of double beta decays are highlighted. An analysis of Gamow-Teller transitions in the mass range A = 62 − 142 is presented and its results are compared with those of many previous works. The enhancement of the axial charge is discussed for first-forbidden pseudoscalar β transitions. Higher-forbidden β transitions are introduced and their role in determining the effective value of gA is examined, in particular from the point of view of the β-decay half-lives and the shapes of electron spectra of forbidden non-unique β transitions. peerReviewed
Value of the Axial-Vector Coupling Strength in β and ββ Decays : A Review
2017
In this review the quenching of the weak axial-vector coupling constant, $g_{\rm A}$, is discussed in nuclear $\beta$ and double-$\beta$ decays. On one hand, the nuclear-medium and nuclear many-body effects are separated, and on the other hand the quenching is discussed from the points of view of different many-body methods and different $\beta$-decay and double-$\beta$-decay processes. Both the historical background and the present status are reviewed and contrasted against each other. The theoretical considerations are tied to performed and planned measurements, and possible new measurements are urged, whenever relevant and doable. Relation of the quenching problem to the measurements of …
DNA-Binding and Anticancer Activity of Pyrene-Imidazolium Derivatives
2016
DNA-binding investigations showed that two different derivatives endowed with pyrene and imidazolium moieties, 1 and 2, strongly bind both double-stranded DNA and telomeric sequences in G-quadruplex (G4) conformation. The values of the DNA-binding constants indicate that 1 and 2 show preferential affinity for G4-DNA, of about one and two orders of magnitude, respectively. Moreover, 1 and 2 inhibit short and long-term proliferation of breast cancer cell lines in a time- and dose-dependent fashion. Remarkably, senescence assays indicate that telomeric G4-DNA is a possible biotarget for the cytotoxic activity of 2. Molecular dynamics simulations suggest that the stronger binding of 2 with G4-D…
Paradoxical effect of l-arginine: Acceleration of endothelial cell senescence
2009
We have recently shown that inhibition of nitric oxide (NO) synthesis by asymmetrical dimethylarginine (ADMA) accelerated endothelial cell (EC) senescence which was prevented by coincubation with L-arginine; however the effect of long-term treatment of l-arginine alone on senescence of ECs have not been investigated. Human ECs were cultured in medium containing different concentrations of L-arginine until senescence. L-Arginine paradoxically accelerated senescence indicated by inhibiting telomerase activity. Moreover, L-arginine decreased NO metabolites, increased peroxynitrite, and 8-iso-prostaglandin F(2alpha) formation. In old cells, the mRNA expression of human amino acid transporter (h…
Down-Regulation of Ku Autoantigen, DNA-Dependent Protein Kinase, and Poly(ADP-ribose) Polymerase during Cellular Senescence
1997
During aging and cellular senescence mutations accumulate in genomic and mitochondrial DNA. Ku autoantigens, DNA-dependent protein kinase, and poly (ADP-ribose) polymerase have an essential role in DNA damage recognition. Our purpose was to find out whether cellular senescence of fibroblasts affects the protein components that recognize DNA damage and induce the repair process. We compared presenescent and replicatively senescent human WI-38 fibroblasts with each other and with SV-40 immortalized and serum-deficient quiescent WI-38 cells. Our results showed that replicative senescence significantly decreased the nuclear level of both p70 and p86 components of Ku autoantigen. SV-40 immortali…
Neural Mechanisms Underlying Human Auditory Evoked Responses Revealed By Human Neocortical Neurosolver
2022
Funding Information: This study was supported by National Institutes of Health (Grant Nos. NIBIB RO1 EB022889, NIMH RO1 MH106174). Publisher Copyright: © 2021, The Author(s). Auditory evoked fields (AEFs) are commonly studied, yet their underlying neural mechanisms remain poorly understood. Here, we used the biophysical modelling software Human Neocortical Neurosolver (HNN) whose foundation is a canonical neocortical circuit model to interpret the cell and network mechanisms contributing to macroscale AEFs elicited by a simple tone, measured with magnetoencephalography. We found that AEFs can be reproduced by activating the neocortical circuit through a layer specific sequence of feedforwar…
Sepiapterin reductase in cultured human cells.
1987
Sepiapterin reductase, an enzyme involved in the synthesis of tetrahydrobiopterin (the natural cofactor for phenylalanine, tyrosine and tryptophan hydroxylases), has been assayed in cultured human amniotic fibroblasts and in cultured mononuclear blood cells. In both cases, the Michaelis constants for sepiapterin and NADPH were essentially equal; 20 microM and 6 microM respectively for stimulated mononuclear blood cells and 22 microM and 5 microM respectively for amniotic fibroblasts. The inhibition by N-acetylserotonin was also similar in both cases. The concentration that produced 50% inhibition in stimulated mononuclear blood cells and in amniotic fibroblasts was 2 microM. The results str…
Two changes of the same nucleotide confer resistance to diuron and antimycin in the mitochondrial cytochrome b gene of Schizosaccharomyces pombe
1988
AbstractDiuron (3-(3,4-dichlorophenyl)-1,1-dimethylurea) and antimycin, both inhibitors of mitochondrial respiration, block electron flow between cytochromes b and c1. Mutants resistant to either drug have been selected using Schizosaccharomyces pombe strains with an extrachromosomally inherited mutator. In analogy to Saccharomyces cerevisiae these mutational sites were assumed to map in the cytochrome b gene. DNA sequence analysis showed that two changes in the same nucleotide are responsible for resistance to antimycin and diuron. Analysis of resistant and sensitive progeny of crosses between the mutants and the wild type confirmed the correlation between mutational alteration and resista…