Search results for "Biotransformations"

showing 3 items of 3 documents

Carbamazepine exposure in the sea anemones Anemonia sulcata and Actinia equina: Metabolite identification and physiological responses

2020

Trabajo presentado en el 11º Congreso Ibérico, 8º Iberoamericano de Contaminación y Toxicología (CICTA 2018) celebrado en la Escuela Técnica Superior de Ingeniería de Montes, Forestal y del Medio Natural, Madrid del 11 al 13 de julio de 2018

Environmental Engineering010504 meteorology & atmospheric sciencesMetaboliteZoologyCarbohydrate metabolism010501 environmental sciences01 natural scienceschemistry.chemical_compoundMediterranean seaBiotransformationBiotransformationsAnthozoaMediterranean SeaAnimalsEnvironmental ChemistryEcotoxicologyWaste Management and DisposalEcosystem0105 earth and related environmental sciencesMass spectrometrybiologyChemistryMetabolismAnthozoabiology.organism_classificationBioaccumulationPollutionCarbamazepineSea AnemonesBioaccumulationPharmaceuticalsWater Pollutants ChemicalActiniaScience of The Total Environment
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Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes

2015

The adverse effects to humans and environment of only few chemicals are well known. Absorption, distribution, metabolism, and excretion (ADME) are the steps of pharmaco/toxicokinetics that determine the internal dose of chemicals to which the organism is exposed. Of all the xenobiotic-metabolizing enzymes, the cytochrome P450 (CYP) enzymes are the most important due to their abundance and versatility. Reactions catalyzed by CYPs usually turn xenobiotics to harmless and excretable metabolites, but sometimes an innocuous xenobiotic is transformed into a toxic metabolite. Data on ADME and toxicity properties of compounds are increasingly generated using in vitro and modeling (in silico) tools.…

Quantitative structure–activity relationshipcytochrome P450In silicoMetabolitexenobioticReviewBiologyPharmacologyXenobiotics03 medical and health scienceschemistry.chemical_compound0302 clinical medicineCYP P450sToxicokineticsPharmacology (medical)aineenvaihdunta030304 developmental biologyADMEPharmacology0303 health sciencesIn silico modelingQSARlcsh:RM1-950Cytochrome P450docking studiesmodelingLigand (biochemistry)3. Good healthbiotransformationslcsh:Therapeutics. PharmacologychemistryBiochemistryin silico030220 oncology & carcinogenesisbiology.proteinXenobioticmetabolismFrontiers in Pharmacology
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Mind the gap—deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites—a position paper focusing on …

2015

This is an open access article under the terms of the Creative Commons Attribution-Non-Commercial-NoDerivs Licence.-- et al.

Food processingColonFood HandlingMetabolitePhytochemicalsBiological AvailabilityReviewsReviewPharmacologyBiologymedicine.disease_causeGastrointestinal epitheliumchemistry.chemical_compoundSDG 3 - Good Health and Well-beingBiotransformationsIntestine SmallmedicineHumansTissue DistributionCarotenoidBiotransformationchemistry.chemical_classificationMicrobiotaPolyphenolsCarotenoidsGastrointestinal MicrobiomeBioavailabilityTransportersIntestinal AbsorptionSolubilityPhytochemicalBiochemistrychemistryPolyphenol/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingEffluxOxidative stressMixed dietFood ScienceBiotechnologyMolecular Nutrition & Food Research
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