Search results for "BirA"
showing 10 items of 32 documents
Treatment with abiraterone in metastatic castration-resistant prostate cancer patients progressing after docetaxel: a retrospective study.
2017
The aim of this study was to evaluate abiraterone's efficacy in Italian patients affected with metastatic prostate cancer progressing after treatment with docetaxel. We conducted a retrospective analysis of 60 patients. Prostate-specific antigen (PSA) reduction in serum was the primary endpoint for evaluating the efficacy of abiraterone in combination with prednisone treatment, whereas reduced pain, safety, progression-free survival, response rate, and overall survival (OS) were secondary endpoints. A significant correlation was noticed between PSA response and OS. Further, the Index Bravais-Pearson (r) correlation allowed us to observe a significant negative interdependence between PSA res…
Development of polypeptide-based therapeutics for the treatment of castration resistant prostate cancer
2019
El cáncer de próstata (CaP) es el segundo cáncer más frecuente en los hombres. Los estudios han establecido el gen de fusión (T2E) compuesto por TMPRSS2 (serina proteasa dependiente de andrógenos) y ERG (factor de transcripción de la familia ETS) como un biomarcador potencial de CaP. La progresión en el CaP incluye tanto el receptor de andrógenos (AR) como el receptor del factor de crecimiento de insulina 1 (IGF-1R), y el tratamiento con un anticuerpo anti-IGF-1R (AVE1642) ha demostrado un gran potencial en el tratamiento de los pacientes con CaP T2E-positivos. Por ello, el desarrollo de terapias personalizadas basadas en polímeros terapéuticos puede favorecer el tratamiento de CaP para un …
Geometry of the projectivization of ideals and applications to problems of birationality
2018
In this thesis, we interpret geometrically the torsion of the symmetric algebra of the ideal sheaf I_Z of a scheme Z defined by n+1 equations in an n-dimensional variety. This is equivalent to study the geometry of the projectivization of I_Z. The applications of this point of view concern, in particular, the topic of birational maps of the projective space of dimension 3 for which we construct explicit birational maps that have the same algebraic degree as their inverse, free and nearly-free curves for which we generalise a characterization of free curves by extending the notion of Milnor and Tjurina numbers. We tackle also the topic of homaloidal hypersurfaces, our original motivation, fo…
Xarxes agroecològiques locals com a resposta social al problema global de l'alimentació: El cas d'Alcoi
2015
En la primera part de l'article, es presenta de manera contextualitzada el panorama desolador de l'alimentació al món. En la segona part, s'explica detalladament la proposta local de creació i posada en marxa d'una xarxa agroecològica a la població d'Alcoi, que ve funcionant des de l'any 2009. Per últim, conclou l'article destacant alguns reptes de futur (no tots, és clar) amb els quals ens trobem no només els membres que formem part de la xarxa agroecològica alcoiana, sinó també la resta de persones que formem la societat.
Stereotactic body radiotherapy in oligoprogressive metastatic castration-resistant prostate cancer during abiraterone or enzalutamide
2022
Introduction: This monocentric, single-arm, retrospective study investigated the role of stereotactic body radiotherapy in patients with metastatic castration resistant prostate cancer who experienced oligoprogression during androgen receptor targeted agents. Methods: We retrospectively enrolled metastatic castration resistant prostate cancer patients treated with androgen receptor targeted agents between December 2016 and January 2022. All patients experienced an oligoprogression (defined as the appearance and/or the progression of ⩽5 bone or nodal or soft tissue metastases) during treatment with androgen receptor targeted agents and received stereotactic body radiotherapy upon oligoprogre…
Actions de tores algébriques sur des corps de caractéristique zéro
2023
Over an algebraically closed field of characteristic zero, normal affine varieties endowed with an effective torus action were described by Altmann and Hausen in 2006 by a geometrico-combinatorial presentation.Using Galois descent tools, we extend this presentation to the case where the ground field is an arbitrary field of characteristic zero. In this context, the acting torus may be non split and may have non-trivial torsors, thus we need additional data to encode such varieties. We provide some situations where the generalized Altmann-Hausen presentation simplifies. For instance, if the acting torus is split, we recover mutatis mutandis the original Altmann-Hausen presentation. Finally, …
Standard classes on the blow-up of $\mathbb{P}^n$ at points in very general position
2012
Combining anticancer drugs with osteoprotective agents in prostate cancer—A contemporary update
2018
Recently, a plethora of life-prolonging cytotoxic, next-generation hormonal, immunotherapeutical as well as radionuclide therapies has emerged as a standard care for metastasized castration-resistant prostate cancer. Being strikingly effective in cancer control, these novel therapies might in fact exert a beneficial impact on skeletal events. Therefore, combining anticancer drugs with osteoprotective agents might lead to additional clinical advantage but must be weighed against simultaneously exposing patients to serious toxicities. In addition, further survival prolongation by changing treatment paradigm in both metastasized hormone-sensitive and nonmetastatic castration-resistant disease …
Health-related Quality of Life in Patients with Advanced Prostate Cancer: A Systematic Review
2021
Abstract Context The assessment of “soft” endpoints such as health-related quality of life (HRQOL) is increasingly relevant when evaluating the optimal treatment sequence of novel therapeutic options in patients with advanced prostate cancer (PCa). Objective To systematically review contemporary data regarding HRQOL outcomes in patients with advanced PCa. Evidence acquisition A systematic review of the literature published between January 2011 and March 2019 was performed using the PubMed/Medline Database. In total, 873 articles were screened, and 14 articles including 12 661 patients were selected for synthesis and included in the current analysis according to the Preferred Reporting Items…
A new species of Charinus Simon, 1892 (Amblypygi, Charinidae) from termite nests in French Guiana
2015
The genus Charinus is represented by 51 species, distributed in all tropical regions. Their small size allows them to use a wide range of micro-habitats, from caves, litter to insect nests. The new species C. sillami sp. nov. was found into termite nests of three different species: Neocapritermes taracua, Spinitermes sp. and Embiratermes neotenicus. Only Paracharon caecus (Paleoamblypygi: Paracharontidae) was previously known to be associated with Isoptera. Eleven species of Charinus were previously known from Northern South America. Charinus sillami sp. nov. is the second species of the genus occurring in French Guiana. An updated key of Northern South-American species is provided.