Search results for "Blood"

0326: Prognostic factors and impact of blood pressure level during the first 48 hours after myocardial infarction

2016

Background High blood pressure and low blood pressure are perfectly identified cardio-vascular risk factors, especially in primary prevention. However, their respective role after myocardial infarction is uncertain, with few data available. Objectives To compare cardio-vascular deaths and events after myocardial infarction between the different blood pressure levels observed during the first forty-eight hours. Methods We carried out an observational, prospective, monocentric study, including all consecutive patients admitted in Dijon’s Cardiologic Intensive Care Unit for myocardial infarction, between February 2012 and February 2014. Systolic blood pressure (SBP) was defined as the average …

Metabolic syndrome therapy: Prevention of vascular injury by antidiabetic agents

2005

More than 65 million Americans are currently obese. Type 2 diabetes mellitus, frequently seen in obese subjects, affects 17 million adults in the United States, with a continuous and alarmingly increasing rate. To prevent development of diabetes in those who are at high risk, it is recommended to optimize meal planning and enhance physical activity to make sustained weight reduction possible. In addition to lifestyle changes, various oral antidiabetic agents are available, with diverse mechanisms of action. Some target defective insulin secretion (sulphonylureas, benzoic acid derivatives) or glucose absorption (glycosidase inhibitors), whereas others target insulin resistance (metformin, th…

Management of high blood pressure in children and adolescents: recommendations of the European Society of Hypertension.

2009

Hypertension in children and adolescents has been gaining ground in cardiovascular medicine, mainly due to the advances made in several areas of pathophysiological and clinical research. These guidelines arose from the consensus reached by specialists in the detection and control of hypertension in children and adolescents. Furthermore, these guidelines are a compendium of scientific data and the extensive clinical experience it contains represents the most complete information that doctors, nurses and families should take into account when making decisions. These guidelines, which stress the importance of hypertension in children and adolescents, and its contribution to the current epidemi…

Control Of Organ Transplant-Associated Graft-versus-Host Disease By Activated Host Lymphocyte Infusions

2004

Background Prolonged persistence of donor-derived T cells after organ transplantation has been proposed to improve long-term allograft survival. However, surviving transplant-derived T cells are also able to mediate devastating graft-versus-host disease (GvHD). Currently, GvHD after organ transplantation is usually refractory to conventional therapy and the disease outcome fatal. Methods Graft-reactive host T cells were generated ex vivo from a patient suffering from a severe and refractory liver-transplant-associated GvHD. To control GvHD, activated alloreactive host T cells were repetitively retransferred into the patient (activated host lymphocyte infusion [aHLI]). Results Adoptive trans…

Transient Neonatal Hypercholesterolemia

1993

In order to obtain new information about the relationship between transient neonatal hypercholesterolemia and adrenal gland function, we have studied 39 healthy babies found hypercholesterolemic at birth and 39 healthy controls with normal cholesterol levels. The results of this study have shown that levels of dehydroepiandrosterone sulfate in cord blood were not significantly different in the hypercholesterolemic subjects compared with normolipidemic controls (1.4 +/- 0.5 micrograms/dl vs 1.3 +/- 0.5 mu/dl). Moreover correlations between this hormone and levels of total and LDL-cholesterol were not only not statistically significant but even positive (respectively r = +0.207 and +0.195). T…

Management of Blood Pressure and Heart Rate in Patients with Acute Stroke

2017

BACKGROUND: Stroke represent one of the most devastating of all neurological diseases, affecting about 15 million people per year and is an important cause of morbidity and mortality worldwide and currently the leading cause of adult disability in developed countries. Blood pressure and heart rate may undergo several modifications in patients with both ischemic and hemorrhagic stroke in fact raised blood pressure levels may lead to cerebral edema, hematoma expansion or hemorrhagic transformation and in contrast low blood pressure can lead to increased cerebral infarction or perihematomal ischemia. In addition, ECG abnormalities and cardiac arrhythmias, especially atrial fibrillation, are re…

Cardiovascular effects of nocturnal aircraft noise on healthy volunteers

2013

Background: Nighttime aircraft noise can impair sleep quality and may also increase blood pressure and the risk for myocardial infarction for persons in highly noise exposed residential areas. Pathophysiology and possible susceptibility factors for cardiovascular effects of aircraft noise remain unclear. Methods and results: 75 healthy volunteers (mean age 26 y) were studied for three nights in their homes. One control pattern without noise (Control) and two noise patterns with 30 (Noise 30) or 60 (Noise 60) aircraft noise events were played back in random and blinded order. After each study night flow-mediated dilatation (FMD) of the brachial artery was measured the following the morning. …

Effect of sodium bicarbonate and beta-alanine supplementation on maximal sprint swimming

2013

Background. This study examined the effect of simultaneous supplementation of extracellular buffer sodium bicarbonate (SB) and intracellular buffer beta-alanine (BA) on maximal sprint swimming. Methods. Thirteen competitive male swimmers completed 4 different treatments (placebo [PL], SB, BA + PL, and BA + SB) in a crossover procedure. PL or SB supplementation (0.3 g/kg body weight) was ingested 60 min before two maximal 100-m freestyle swims that were performed with a passive recovery of 12-min between each swim. Because of the known long washout period for carnosine, four weeks of BA supplementation (4.8 g per day) was started after the first week of PL or SB supplementation and performan…

Can clinically relevant histamine release be accurately diagnosed in anaesthetised patients without plasma histamine measurements? Randomised study w…

1998

Noninvasive assessment of baroreflex sensitivity in post-MI patients by an open loop parametric model of RR-systolic pressure interactions

2003

Noninvasive evaluation of baroreflex sensitivity is considered an important goal for diagnosis and prognosis in post-MI patients. Methodological approach and physiological measure conditions may be the main causes for the differences found with respect to the standard Phenylephrine test. In this study, three linear parametric models, describing variability and mutual interactions of RR interval and systolic arterial pressure (SAP), were compared in relation to their ability to quantify baroreflex gain, using the Phenylephrine test index (Phe/sub BRS/) as reference. By monovariate autoregressive (AR) model, bivariate AR model and open loop ARXAR model, specific gain indexes (/spl alpha//sub …