Search results for "Bone"
showing 10 items of 2629 documents
Endothelial cells stimulate osteogenic differentiation of mesenchymal stem cells on calcium phosphate scaffolds
2012
The interaction of mesenchymal stem cells (MSCs) with endothelium in vivo is significant for regenerative processes in organisms. To design concepts for tissue engineering for bone regeneration based on this interaction, the osteogenic differentiation of human bone marrow-derived MSCs in a co-culture with human dermal microvascular endothelial cells (HDMECs) was studied. The experiments were focussed on the regulation of MSCs in a co-culture with HDMECs on different calcium phosphate scaffolds. Alkaline phosphatase (ALP) activity and mRNA expression of various osteogenic markers increased significantly when cells were co-cultured on materials with calcium phosphate scaffolds compared to tis…
Inhibition of Lymphocyte Proliferation during Parasitic Infection with Nippostrongylus Brasiliensis
1979
It is now well established that parasitic infections can lead to the production of high titers of IgE anti parasitic antibodies in experimental animals and in man (1,2). One of the best studied experimental systems involves the ability of the nematode parasite Nippostrongylus brasiliensis (N.B.) to stimulate a high titer reaginic antibody response to worm antigens in the rat. These studies were extended by the reports of Orr and Blair that parasitic infections can cause non specific proliferation of IgE antibody response against antigens unrelated to those of the parasite (3). The amplification of an already existing IgE antibody response can be induced before infection by inoculating the a…
Significance of immunohistochemistry biomarkers in prediction of malignant transformation of oral lichen planus
2022
Background: Oral lichen planus (OLP) is a chronic inflammatory disorder with increased risk for malignant transformation. Biomarker validation is a pivotal step in moving newly discovered biomarkers towards clinical implementation. We performed a systematic review of studies on biomarkers related to OLP, wherein biomarkers have been described in at least two independent studies. Our aim was to determine whether any of these biomark-ers might be promising in predicting the increased risk of malignant transformation of OLP. Material and Methods: We searched the following databases until August 2021: PUBMED, EMBASE, and Web of Science. Due to high heterogeneity, a qualitative rather than quant…
Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020
2020
The Medication-Related Osteonecrosis of Jaws (MRONJ) diagnosis process and its prevention play a role of great and rising importance, not only on the Quality of Life (QoL) of patients, but also on the decision-making process by the majority of dentists and oral surgeons involved in MRONJ prevention (primary and secondary). The present paper reports the update of the conclusions from the Consensus Conference—held at the Symposium of the Italian Society of Oral Pathology and Medicine (SIPMO) (20 October 2018, Ancona, Italy)—after the newest recommendations (2020) on MRONJ were published by two scientific societies (Italian Societies of Maxillofacial Surgery and Oral Pathology and Medicine, SI…
Bone Density, Balance and Quality of Life of Postmenopausal Women Taking Alendronate Participating in Different Physical Activity Programs
2010
Made available in DSpace on 2022-04-28T19:04:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-01 Background: The objective of this study was to determine the effects of different physical activity (PA) programs on bone density, balance and quality of life of postmenopausal women taking concomitant alendronate. A quasi-experimental study was conducted with 35 volunteers divided into four groups: practitioners of resistance training (RTG, n = 9, 49.8±4.2 years), judo (JUG, n = 11, 52.2±5.3 years), water aerobics (WAG, n = 8, 57.1±7.4 years) and the control group (CG, n = 7, 53.8±4.4 years). Methods: The following assessment tools were used: bone mineral density (BMD) measured by d…
East meets west in the 6th millennium: Mesolithic osseous tools and art from Sise on the Latvian seaboard
2021
A collection of 141 bone and antler tools and debitage pieces recovered from the River Užava at the village of Sise constitutes the largest Mesolithic osseous assemblage in western Latvia. Radiocarbon dating of 12 pieces suggests that most of this collection dates from the 6th millennium calBC. We present a general analysis, highlighting typical and unique tool forms, ornamented and sculpted pieces, and assess the corpus in a wider geographical context. Predominant in this rich and diverse collection are heavy duty antler tools: various forms of adzes, axes and hammers as well as sleeves, made either from shed antler or antler of hunted animals. They include two pieces classifiable as T-axe…
OPTIMIZING PREIMPLANTARY OFFER TROUGH PIEZOSURGERY TECHNIQUES
2016
Introduction. In most of the cases, duet o post-extractional atrophy the bone offer is insufficent for placing implants. Piezosurgery splitting techniques represent the modern and non-invasive alternative used for ridge remodeling, sinus lift and other surgical bone preservation maneuvres. Purpose. The purpose of this study is to present new surgical techniques that radically simplify maxillary sinus interventation, avoiding membrane perforation and new splitting tecniques in advanced bone and ridge atrophy. Material and method. In this study, sinus lifting was performed using piezo-elevation of the membrane and the pressure ogenerated by the saline solution. Out of 67 patients, 20 have had…
Ti6Al4V Surface Modification Techniques to Modulate Bone Cell Response: A Review
2022
Biomaterial-tissue interactions are known to largely affect implant performance, relating to alteration of physiological processes. Within this context, metals continue to have a major role as most implants contain at least one metallic part. In particular, titanium alloys are of pivotal importance in orthopedics and dentistry. Being osteointegration somewhat affected by implant surface conditions, surface modifications, surface modification qualify as a way to modulate tissue response, net of an effective design of the whole implant. Currently, a lack of full understanding on the direction to be taken for proper techniques and process conditions to be employed, for the regulation of osteoi…
Systemic risk factors for peri-implant bone loss: a systematic review and meta-analysis
2014
The aim of this study was to determine the influence of patient-related systemic risk factors (systemic disease, genetic traits, chronic drug or alcohol consumption, and smoking status) on peri-implant bone loss at least 1 year after implant installation and prosthetic loading. An electronic search was performed of MEDLINE, EMBASE, and The Cochrane Central Register of Controlled Trials up to January 2012. One thousand seven hundred and sixty-three studies were identified. After applying a three-stage screening process, 17 articles were included in the qualitative analysis, but only 13 in the quantitative analysis, since smoking was a common exposure. The meta-analysis of these 13 studies (4…
Monoclonal Gammopathies and the Bone Marrow Microenvironment: From Bench to Bedside and Then Back Again
2023
Multiple myeloma (MM) is an incurable hematologic malignancy characterized by a multistep evolutionary pathway, with an initial phase called monoclonal gammopathy of undetermined significance (MGUS), potentially evolving into the symptomatic disease, often preceded by an intermediate phase called “smoldering” MM (sMM). From a biological point of view, genomic alterations (translocations/deletions/mutations) are already present at the MGUS phase, thus rendering their role in disease evolution questionable. On the other hand, we currently know that changes in the bone marrow microenvironment (TME) could play a key role in MM evolution through a progressive shift towards a pro-inflammatory and…