Search results for "Brainstem"

Migraine as a Cortical Brain Disorder

2020

Purpose Migraine is an exclusively human chronic disorder with ictal manifestations characterized by a multifaceted clinical complexity pointing to a cerebral cortical involvement. The present review is aimed to cover the clinical, neuroimaging, and neurophysiological literature on the role of the cerebral cortex in migraine pathophysiology. Overview Converging clinical scenarios, advanced neuroimaging data, and experimental neurophysiological findings, indicate that fluctuating excitability, plasticity, and metabolism of cortical neurons represent the pathophysiological substrate of the migraine cycle. Abnormal cortical responsivity and sensory processing coupled to a mismatch between the …

The zona incerta system: Involvement in attention and movement

2021

The zona incerta (ZI) is a large structure made of four neurochemically defined regions (at least, in rodents). It is globally involved in complex connections with telencephalic and brainstem centers. In this work, we focus on some of the anatomical links this structure develops with the cerebral cortex and the tectum. We also point to its integration within a larger basal ganglia network. The functions of this region are still mysterious, even if recent works suggest its participation in behavioral expression. Studies about the functional organization of the vibrissal system have provided the first integrated model, illustrating the ZI's role in sensory-motor programing. In addition, ZI co…

The topographic diagnosis of acquired nystagmus in brainstem disorders.

2002

Evidence is presented for a clinical classification of central vestibular syndromes according to the three major planes of action of the vestibulo-ocular reflex (VOR): yaw, pitch, and roll. The plane-specific vestibular syndromes are determined by ocular motor, postural, and perceptual signs. Yaw plane signs are horizontal nystagmus, horizontal past pointing, rotational and lateral body falls to the right or to the left, and horizontal deviation of perceived straight-ahead. Pitch plane signs are upbeat/downbeat nystagmus, forward/backward tilts and falls, and upward or downward deviations of the perceived horizontal. Roll plane signs are torsional nystagmus, skew deviation, ocular torsion, …

Vaskulärer Schwindel

2002

Ischemia,hemorrhages, and other vascular disorders can result in various central or peripheral vestibular syndromes with vertigo, oculomotor/balance disturbances, and nausea. The vascular vertigo syndromes listed in Table 1 can however be brought about by other causes such as demyelitizing focuses in multiple sclerosis or space-occupying lesions, so that not only localization of the damaged structure but also the various etiologies are decisive for the choice of therapy. Occasionally, combined functional disturbances of the peripheral and central vestibular system appear, such as an infarction of the inferior anterior cerebellar artery, which supplies the labyrinth and parts of the brainste…

Brainstem Anatomy of White Matter Tracts Using Diffusion Weighted Imaging

1998

Detección precoz de la hipoacusia, influencia en el diagnóstico y en el tratamiento temprano

2021

Detección precoz de la hipoacusia, influencia en el diagnóstico y en el tratamiento temprano. INTRODUCCIÓN: La hipoacusia es el déficit sensorial mas frecuente en los países desarrollados. La prevalencia de cualquier grado de hipoacusia es de un 2-3 % de la población infantil y el 80% de las mismas, está presente al nacimiento. Los programa de screening auditivo (SA) se justifican por la alta incidencia de la hipoacusia y sus consecuencias devastadoras para el lenguaje cuando no se detecta precozmente. OBJETIVO: Establecer el número de niños diagnosticados de hipoacusia congénita gracias al SA en el hospital Universitario La Fe. Analizamos las técnicas utilizadas en el cribado, los parámetr…

Descending Connections from the Brainstem to the Spinal Cord in the Electric Fish <i>Eigenmannia</i>

1990

The descending connections from the brainstem to the spinal cord in Eigenmannia sp. were demonstrated using the horseradish peroxidase (HRP) technique. The spinal cord was transecte

The influence of nimodipine on chromatolysis of motoneurons following axotomy with and without reinnervation: A quantitative image analysis

1996

Using a recently developed image analysis method to quantify the time course of chromatolysis in injured motorneurons we tested the effect of the calcium entry blocker nimodipine (1000 ppm in food pellets) on regenerating and degenerating motoneurons. Following facial-facial, hypoglossal-hypoglossal anastomosis with complete regeneration and following facial and hypoglossal nerve resection which causes a partial neuronal degeneration and postoperative survival times of 4 to 112 days, the texture of the Nissl substance of facial and hypoglossal motoneurons was analyzed on both sides of the brainstem in paraffin serial sections with a VIDASplus image analyzer. Monitoring alterations of the Ni…

Chapter 4 3D brainstem topodiagnosis – a voxel-based model analyzing MR imaging data

2006

Publisher Summary This chapter presents a new method of statistically based three-dimensional (3D) brainstem mapping to identify brainstem structures responsible for specific clinical and electrophysiological abnormalities. To ensure reliable correlations, a large cohort of patients with magnetic resonance (MR)-documented brainstem infarctions were recruited in two European neurological institutions—namely, the Department of Neurology, Johannes Gutenberg University, Mainz, Germany, and the Department of Neurological Sciences, “La Sapienza” University of Rome, Italy. This method minimizes the risk of highlighting vascular territories rather than the structures specifically responsible for th…

O047. The sound-induced flash illusions reveal visual cortex hyperexcitability in cluster headache

2015

Objectives Pathophysiology of cluster headache (CH) is not wellknown. Although posterior hypothalamus has been suggested to play a pivotal role, evidence exists of a more diffuse involvement of the central nervous system including brainstem and cerebral cortex. In this regard, we recently observed increased motor cortical excitability in episodic CH patients both outside and inside bout [1]. The sound-induced flash illusions (SIFI) represent an example of multisensory integration, and provide a tool to indirectly explore the excitability state of the visual cortex [2]. SIFI are classified as “fission” and “fusion” illusions. When one visual stimulus (flash) is accompanied by two or more aud…