Search results for "Brea"

Oxidative stress, oxidative stress-based diseases and Mediterranean diet. Raman spectroscopy monitoring of skin carotenoids in healthy individuals an…

Abstract Evaluating the level of body antioxidants may reveal a more or less severe oxidative stress condition in either healthy people or subjects with pathologies, and can be suggestive for suitable dietary interventions to possibly affect it. In this work taking advantage from the Raman spectroscopic technology to measure the level of skin carotenoids in a simple and non-invasive manner, healthy people (age 15 to 70, n=155) and women who had surgery for breast cancer (BC) (age 38 to 76, n=71) have been screened to assess to what extent an increased intake of fruit and vegetables (healthy people and patients), associated with diets based on a classical Mediterranean style and that did not…

p38 MAPK in cadmium-treated MDA-MB231 breast cancer cells

2008

Cell-cycle control in cell-biomaterial interactions

2000

Current biocompatibility testing involves the demonstration of cell proliferation, which is usually interpreted as a sign of positive biocompatibility when the materials sustain cell proliferation. As the field of biomaterials research is rapidly moving toward tissue-engineered devices and hybrid organs, control of cell function has become a main topic. Cell function, which involves specific differentiation pathways, cannot be separated from cell-cycle control. The study of cell-cycle control is an important extension of routine proliferation assays and has extensive roots in developmental and tumor biology. We studied the expression of the tumour suppressor gene p53 and the proliferation-a…

Apollon gene silencing induces apoptosis in breast cancer cells via p53 stabilisation and caspase-3 activation

2009

We analysed the effects of small interfering RNA (siRNA)-mediated silencing of Apollon, a member of the inhibitors of apoptosis protein family, on the proliferative potential and ability of human breast cancer cell lines to undergo apoptosis. In wild-type p53 ZR75.1 cells, Apollon knockdown resulted in a marked, time-dependent decline of cell growth and an increased rate of apoptosis, which was associated with p53 stabilisation and activation of the mitochondrial-dependent apoptotic pathway. Pre-incubation of cells with a p53-specific siRNA resulted in a partial rescue of cell growth inhibition, as well as in a marked reduction of the apoptotic response, indicating p53 as a major player in …

Plausible Role of Estrogens in Pathogenesis, Progression and Therapy of Lung Cancer

2021

Malignant neoplasms are among the most common diseases and are responsible for the majority of deaths in the developed world. In contrast to men, available data show a clear upward trend in the incidence of lung cancer in women, making it almost as prevalent as breast cancer. Women might be more susceptible to the carcinogenic effect of tobacco smoke than men. Furthermore, available data indicate a much more frequent mutation of the tumor suppressor gene-p53 in non-small cell lung cancer (NSCLC) female patients compared to males. Another important factor, however, might lie in the female sex hormones, whose mitogenic or carcinogenic effect is well known. Epidemiologic data show a correlatio…

Elpas trūkums onkoloģiskiem pacientiem. Biežums un problēmas risinājums

2018

Elpas trūkums ir viens no visbiežākajiem un mokošākajiem vēža pacientu simptomiem. Katram pacientam šo simptomu etioloģija, patoģenēze un smaguma pakāpe atšķiras, tas traucē efektīvai ārstēšanai un ir nepieciešama individualizēta pieeja. Šis pētījums izvērtē elpas trūkuma sastopamību un kā tā tiek menedžēta starp termināliem vēža slimniekiem, kā arī simptomu dinamiku un individuālās pacientu atšķirības. Tā kā elpas trūkums ir subjektīvs simptoms un vāji korelē ar objektīviem veselības parametriem, šādi mērījumi šajā pētījumā netiks iekļauti, liekot uzsvaru uz dažādām ārstēšanas metodēm gan farmakoloģiskām, gan nefarmakoloģiskām. Lai to paveiktu, tika izveidota anketa, kas tika izsniegta 46 …

Gender differences in the battle against COVID‐19: Impact of genetics, comorbidities, inflammation and lifestyle on differences in outcomes

2020

Abstract It has been over six months now since the entire globe was struck by the new Coronavirus Disease 2019 (COVID‐19; aka severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2]), which has affected 215 nations. The medical and scientific communities continue to search for and study potential treatments for COVID‐19 as well as an effective vaccine. As of 21 June 2020, 11.4 million cases have been confirmed worldwide, with approximately 530,000 deaths. A large number of scientific papers have been produced, hundreds of thousands of patients have been hospitalized and studied, several treatments and vaccines are being tested in randomized clinical trials, social distancing regulation…

EMU and Trade Revisited: Long-Run Evidence Using Gravity Equations

2013

In this paper, we present evidence of the long-run effect of the euro on trade for the twelve initial EMU countries for the period 1967–2008 from a double perspective. First, we pool all the bilateral combinations of trade flows among the EMU countries in a panel cointegration gravity specification. Second, we estimate a gravity equation for each of the EMU members vis-a-vis the other eleven partners. We apply panel cointegration techniques based on factor models that account for cross-dependence and structural breaks. Whereas the joint gravity equation provides evidence on the aggregate effect of the euro on intra-European trade, by isolating the individual countries, we assess which of th…

Parthenolide induces EGF receptor phosphorylation and superoxide anion production in MDA-MB231 breast cancer cells.

2013

Cell Mediated Immune System Hyperactivation and Complications in Surgery. Is There a Correlation?

2010

Introduction: The role of the immune system in wound healing is multifaceted and cell-to-cell interactions may affect healing in several ways, many of which are probably still unknown. The case of a 19-year-old girl who, after multiple postsurgical complications, was found to have a transient immune system hyperactivation is reported. Materials and Methods: A 19-years-old woman with a breast asymmetry, previously treated with breast augmentation and contralateral reduction mammaplasty, had her implant removed and she came to our attention seeking autologous reconstruction. A free DIEP flap was performed and, again, wound breakdown and liponecrosis ensued at both the donor and recipient site…