Search results for "Bust"
showing 10 items of 1000 documents
Deciphering the histone code to build the genome structure
2017
Histones are punctuated with small chemical modifications that alter their interaction with DNA. One attractive hypothesis stipulates that certain combinations of these histone modifications may function, alone or together, as a part of a predictive histone code to provide ground rules for chromatin folding. We consider four features that relate histone modifications to chromatin folding: charge neutralisation, molecular specificity, robustness and evolvability. Next, we present evidence for the association among different histone modifications at various levels of chromatin organisation and show how these relationships relate to function such as transcription, replication and cell division…
Experimental Evolution and Population Genetics of RNA Viruses
2009
Viral studies have contributed substantially to the field of experimental evolution during the last two decades. The rapid evolution of RNA viruses makes them especially suitable for investigating real-time evolution, while their small genomes facilitate the analysis of the genetic basis of evolutionary change. We review recent advances in RNA virus experimental evolution, focusing on genetic properties that differentiate them from DNA-based organisms, such as their high mutation rates, small genome sizes, low genetic robustness, and the predominance of antagonistic epistasis. We argue that these properties can explain many aspects of RNA virus evolution, including rapid evolution, marked f…
Mutational fitness effects in RNA and single-stranded DNA viruses: common patterns revealed by site-directed mutagenesis studies
2010
The fitness effects of mutations are central to evolution, yet have begun to be characterized in detail only recently. Site-directed mutagenesis is a powerful tool for achieving this goal, which is particularly suited for viruses because of their small genomes. Here, I discuss the evolutionary relevance of mutational fitness effects and critically review previous site-directed mutagenesis studies. The effects of single-nucleotide substitutions are standardized and compared for five RNA or single-stranded DNA viruses infecting bacteria, plants or animals. All viruses examined show very low tolerance to mutation when compared with cellular organisms. Moreover, for non-lethal mutations, the me…
Selection for thermostability can lead to the emergence of mutational robustness in an RNA virus
2010
Mutational robustness has important evolutionary implications, yet the mechanisms leading to its emergence remain poorly understood. One possibility is selection acting on a correlated trait, as for instance thermostability (plastogenetic congruence). Here, we examine the correlation between mutational robustness and thermostability in experimental populations of the RNA bacteriophage Qβ. Thermostable viruses evolved after only six serial passages in the presence of heat shocks, and genome sequencing suggested that thermostability can be conferred by several alternative mutations. To test whether thermostable viruses have increased mutational robustness, we performed additional passages in …
The Role of Ancestral Duplicated Genes in Adaptation to Growth on Lactate, a Non-Fermentable Carbon Source for the Yeast Saccharomyces cerevisiae
2021
This article belongs to the Section Molecular Informatics.
A Life Cycle Environmental Impact Comparison between Traditional, Hybrid, and Electric Vehicles in the European Context
2021
Global warming (GW) and urban pollution focused a great interest on hybrid electric vehicles (HEVs) and battery electric vehicles (BEVs) as cleaner alternatives to traditional internal combustion engine vehicles (ICEVs). The environmental impact related to the use of both ICEV and HEV mainly depends on the fossil fuel used by the thermal engines, while, in the case of the BEV, depends on the energy sources employed to produce electricity. Moreover, the production phase of each vehicle may also have a relevant environmental impact, due to the manufacturing processes and the materials employed. Starting from these considerations, the authors carried out a fair comparison of the environmental …
The Role of Education in Self–Employment Success in Finland
2002
This paper analyzes the effect of self–employed persons’ education on the success of their firms during the economic downturn and upturn of the 1990's. It is found that the business cycle affects the relative closure rates of firms run by self–employed with any level of education. Exit probability is lower for the highly educated during bust, but higher in boom. This is accounted for by two facts. First, running a small firm is argued to be a less attractive choice to wage work, particularly for the highly educated, due to lower earning prospects, less stable stream of earnings, and the cultural tradition of working in large corporations. Second, the highly educated faced a higher outside d…
Predicting bond betas using macro-finance variables
2019
We conduct in-sample and out-of-sample forecasting using the new approach of combining explanatory variables through complete subset regressions (CSR). We predict bond CAPM betas and bond returns conditioning on various macro-finance variables. We explore differences across long-term government bonds, investment grade corporate bonds, and high-yield corporate bonds. The CSR method performs well in predicting bond betas, especially in-sample, and, mainly high-yield bond betas when the focus is out-of-sample. Bond returns are less predictable than bond betas.
Online mass flow prediction in CFB boilers with explicit detection of sudden concept drift
2010
Fuel feeding and inhomogeneity of fuel typically cause fluctuations in the circulating fluidized bed (CFB) process. If control systems fail to compensate the fluctuations, the whole plant will suffer from dynamics that is reinforced by the closed-loop controls. This phenomenon causes reducing efficiency and the lifetime of process components. In this paper we address the problem of online mass flow prediction, which is a part of control. Particularly, we consider the problem of learning an accurate predictor with explicit detection of abrupt concept drift and noise handling mechanisms. We emphasize the importance of having domain knowledge concerning the considered case and constructing the…
Robust Principal Component Analysis of Data with Missing Values
2015
Principal component analysis is one of the most popular machine learning and data mining techniques. Having its origins in statistics, principal component analysis is used in numerous applications. However, there seems to be not much systematic testing and assessment of principal component analysis for cases with erroneous and incomplete data. The purpose of this article is to propose multiple robust approaches for carrying out principal component analysis and, especially, to estimate the relative importances of the principal components to explain the data variability. Computational experiments are first focused on carefully designed simulated tests where the ground truth is known and can b…