Search results for "C.M.M."
showing 10 items of 1066 documents
Music for the Brain Across Life
2013
Music is highly a versatile and multifaceted form of art and communication that has been an essential part of human societies since their early days. During the past 20 years, neuroimaging studies have shown that music is a powerful stimulant also for the brain, engaging not just the auditory cortex but also a vast network of temporal, frontal, parietal, cerebellar, and limbic brain areas that govern auditory perception, syntactic and semantic processing, attention and memory, emotion and mood control, and motor skills. Especially regions in the right temporal and frontal cortices are needed for the accurate perception and production of music as abnormal neural development or acquired damag…
Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8+ T cell function by limiting GSH and Cys availability
2015
NF-E2-related factor 2 (Nrf2), known to protect against reactive oxygen species, has recently been reported to resolve acute inflammatory responses in activated macrophages. Consequently, disruption of Nrf2 promotes a proinflammatory macrophage phenotype. In the current study, we addressed the impact of this macrophage phenotype on CD8(+) T cell activation by using an antigen-driven coculture model consisting of Nrf2(-/-) and Nrf2(+/+) bone marrow-derived macrophages (BMDMΦ) and transgenic OT-1 CD8(+) T cells. OT-1 CD8(+) T cells encode a T cell receptor that specifically recognizes MHC class I-presented ovalbumin OVA(257-264) peptide, thereby causing a downstream T cell activation. Interes…
A continuum damage model for functionalized graphene membranes based on atomistic simulations
2017
A continuum model for GO membranes is developed in this study. The model is built representing the membrane as a two-dimensional, heterogeneous, two-phase continuum and the constitutive behavior of each phase (graphitic or oxidized) is built based on DFTB simulations of representative patches. A hyper-elastic continuum model is employed for the graphene areas, while a continuum damage model is more adequate for representing the behavior of oxidized regions. A finite element implementation for GO membranes subjected to degradation and failure is then implemented and, to avoid localization instabilities and spurious mesh sensitivity, a simple crack band model is adopted. The developed impleme…
Biomolecular conjugation inside synthetic polymer nanopores via glycoprotein-lectin interactions
2011
We demonstrate the supramolecular bioconjugation of concanavalin A (Con A) protein with glycoenzyme horseradish peroxidase (HRP) inside single nanopores, fabricated in heavy ion tracked polymer membranes. Firstly, the HRP-enzyme was covalently immobilized on the inner wall of the pores using carbodiimide coupling chemistry. The immobilized HRP-enzyme molecules bear sugar (mannose) groups available for the binding of Con A protein. Secondly, the bioconjugation of Con A on the pore wall was achieved through its biospecific interactions with the mannose residues of the HRP enzyme. The immobilization of biomolecules inside the nanopore leads to the reduction of the available area for ionic tran…
Neutrino transition magnetic moments within the non-standard neutrino-nucleus interactions
2015
Tensorial non-standard neutrino interactions are studied through a combined analysis of nuclear structure calculations and a sensitivity $\chi^2$-type of neutrino events expected to be measured at the COHERENT experiment, recently planned to operate at the Spallation Neutron Source (Oak Ridge). Potential sizeable predictions on transition neutrino magnetic moments and other electromagnetic parameters, such as neutrino milli-charges, are also addressed. The non-standard neutrino-nucleus processes, explored from nuclear physics perspectives within the context of quasi-particle random phase approximation, are exploited in order to estimate the expected number of events originating from vector …
Theory of Neutrinos: A White Paper
2005
During 2004, four divisions of the American Physical Society commissioned a study of neutrino physics to take stock of where the field is at the moment and where it is going in the near and far future. Several working groups looked at various aspects of this vast field. The summary was published as a main report entitled ``The Neutrino Matrix'' accompanied by short 50 page versions of the report of each working group. Theoretical research in this field has been quite extensive and touches many areas and the short 50 page report provided only a brief summary and overview of few of the important points. The theory discussion group felt that it may be of value to the community to publish the e…
Statistical sensitivity of the nEDM apparatus at PSI to n − n′ oscillations
2018
The neutron and its hypothetical mirror counterpart, a sterile state degenerate in mass, could spontaneously mix in a process much faster than the neutron β-decay. Two groups have performed a series of experiments in search of neutron – mirror-neutron (n − n′) oscillations. They reported no evidence, thereby setting stringent limits on the oscillation time τnn′. Later, these data sets have been further analyzed by Berezhiani et al.(2009–2017), and signals, compatible with n − n′ oscillations in the presence of mirror magnetic fields, have been reported. The Neutron Electric Dipole Moment Collaboration based at the Paul Scherrer Institute performed a new series of experiments to further test…
The n2EDM experiment at the Paul Scherrer Institute
2018
We present the new spectrometer for the neutron electric dipole moment (nEDM) search at the Paul Scherrer Institute (PSI), called n2EDM. The setup is at room temperature in vacuum using ultracold neutrons. n2EDM features a large UCN double storage chamber design with neutron transport adapted to the PSI UCN source. The design builds on experience gained from the previous apparatus operated at PSI until 2017. An order of magnitude increase in sensitivity is calculated for the new baseline setup based on scalable results from the previous apparatus, and the UCN source performance achieved in 2016.
Nicotiana tabacum L. hloroplastu izmantošanas iespējas cilvēku cilmes šūnu barotņu bagātināšanai un cilmes šūnu proliferācijas un morfoloģisko izmaiņ…
2016
Lai izvērtētu izolētu tabakas hloroplastu potenciālu kā cilmes šūnu barotni bagātinošu līdzekli, FM-55-P cilvēka melanomas šūnas tika inkubētas 2 dienas ar izolētiem hloroplastiem, kas tika pievienoti šūnu kultūrai kā barotnes atšķaidījums vai kā hloroplastu piedeva. Tika noskaidrots, ka hloroplastu piedeva barotnei neizraisa ievērojamu proliferācijas samazinājumu salīdzinot ar barotnes atšķaidījumu un ka hloroplastu piedevas klātbūtnē melanocīti vairāk atraujas no kultūras virsmas bez šūnu nāves pazīmēm. Hloroplasti barotnē šķietami sadalījās un tika iekļauti melanocītu citoplazmā visos pievienošanas variantos. Izolētu hloroplastu ietekme uz melanomas šūnu kultūru tika vērtēta kā neizteikt…
Photocleavable core cross-linked polymeric micelles of polypept(o)ides and ruthenium(II) complexes
2021
Core cross-linking of polymeric micelles has been demonstrated to contribute to enhanced stability that can improve the therapeutic efficacy. Photochemistry has the potential to provide spatial resolution and on-demand drug release. In this study, light-sensitive polypyridyl-ruthenium(II) complexes were combined with polypept(o)ides for photocleavable core cross-linked polymeric micelles. Block copolymers of polysarcosine-block-poly(glutamic acid) were synthesized by ring-opening N-carboxyanhydride polymerization and modified with aromatic nitrile-groups on the glutamic acid side chain. The modified copolymers self-assembled into micelles and were cross-linked by cis-diaquabis(2,2'-bipyridi…