Search results for "C19"
showing 4 items of 14 documents
Les études hédoniques soutiennent-elles une valeur verte élevée dans le bâtiment ? Une réponse par la méta-analyse
2018
International audience; La place majeure occupée par le secteur du bâtiment dans la consommation d'énergie (40%) et les émissions de gaz à effet de serre (1/3 des émissions) explique le développement du débat scientifique axé sur la réduction de l'impact environnemental du bâtit et sur ses leviers. Ces dernières années ont notamment vu croitre une littérature considérable relative à la disposition à payer du public pour les bâtiments « verts » labélisés par des écolabels, cette « valeur verte » étant estimée dans la grande majorité des études via des modèles hédoniques. Dans cet article, nous proposons d'offrir une synthèse de ces résultats dans le cadre d'une méta-analyse portant sur plus …
Assessing Non-Linear Structures in Real Exchange Rates Using Recurrence Plot Strategies
2002
Severe Tremor After Cotrimoxazole-Induced Elevation of Venlafaxine Serum Concentrations in a Patient With Major Depressive Disorder
2013
: We describe a female patient who was an extensive metabolizer of cytochrome P450 isoenzyme (CYP) 2D6 and an intermediate metabolizer of CYP2C19 (genotype: CYP2C19 *1/*2). She exhibited high serum concentrations of venlafaxine and O-desmethylvenlafaxine and developed severe tremor after comedication with cotrimoxazole (sulfamethazole/trimethoprim). Venlafaxine is mainly metabolized by O- and N-demethylation. O-demethylation is catalyzed by the highly polymorphic CYP2D6 and N-demethylation by several enzymes, CYP2C19, CYP2C9, and CYP3A4. The observed overall pharmacokinetic effect was most probably the result of decreased N-demethylation of venlafaxine by (1) reduced expression of CYP2C19 d…
Binding abilities of polyaminocyclodextrins: polarimetric investigations and biological assays.
2017
Three polyaminocyclodextrin materials, obtained by direct reaction between heptakis(6-deoxy-6-iodo)-β-cyclodextrin and the proper linear polyamines, were investigated for their binding properties, in order to assess their potential applications in biological systems, such as vectors for simultaneous drug and gene cellular uptake or alternatively for the protection of macromolecules. In particular, we exploited polarimetry to test their interaction with some model p-nitroaniline derivatives, chosen as probe guests. The data obtained indicate that binding inside the host cavity is mainly affected by interplay between Coulomb interactions and conformational restraints. Moreover, simultaneous i…