Search results for "C2"
showing 10 items of 879 documents
Synchronization and fluctuations for interacting stochastic systems with individual and collective reinforcement
2020
The Pólya urn is the paradigmatic example of a reinforced stochastic process. It leads to a random (non degenerated) time-limit. The Friedman urn is a natural generalization whose a.s. time-limit is not random anymore. In this work, in the stream of previous recent works, we introduce a new family of (finite) systems of reinforced stochastic processes, interacting through an additional collective reinforcement of mean field type. The two reinforcement rules strengths (one componentwise, one collective) are tuned through (possibly) different rates n −γ. In the case the reinforcement rates are like n −1 , these reinforcements are of Pólya or Friedman type as in urn contexts and may thus lead …
Statistics of transitions for Markov chains with periodic forcing
2013
The influence of a time-periodic forcing on stochastic processes can essentially be emphasized in the large time behaviour of their paths. The statistics of transition in a simple Markov chain model permits to quantify this influence. In particular the first Floquet multiplier of the associated generating function can be explicitly computed and related to the equilibrium probability measure of an associated process in higher dimension. An application to the stochastic resonance is presented.
Exact simulation of diffusion first exit times: algorithm acceleration
2020
In order to describe or estimate different quantities related to a specific random variable, it is of prime interest to numerically generate such a variate. In specific situations, the exact generation of random variables might be either momentarily unavailable or too expensive in terms of computation time. It therefore needs to be replaced by an approximation procedure. As was previously the case, the ambitious exact simulation of exit times for diffusion processes was unreachable though it concerns many applications in different fields like mathematical finance, neuroscience or reliability. The usual way to describe exit times was to use discretization schemes, that are of course approxim…
Cut-off method for endogeny of recursive tree processes
2016
Given a solution to a recursive distributional equation, a natural (and non-trivial) question is whether the corresponding recursive tree process is endogenous. That is, whether the random environment almost surely defines the tree process. We propose a new method of proving endogeny, which applies to various processes. As explicit examples, we establish endogeny of the random metrics on non-pivotal hierarchical graphs defined by multiplicative cascades and of mean-field optimization problems as the mean-field matching and travelling salesman problems in pseudo-dimension q>1.
Sentinel Lymph Node in Aged Endometrial Cancer Patients “The SAGE Study”: A Multicenter Experience
2021
ObjectiveThe incidence of endometrial cancer is increasing in elderly people. Considering that aging progressively affects lymphatic draining function, we aimed to define its impact on IGC uptake during SLN mapping.MethodsA multicenter retrospective cohort of endometrial cancer patients with apparently early-stage endometrial cancer undergoing complete surgical staging with SLN dissection was identified in four referral cancer centers from May 2015 to March 2021. Patients were classified in Group 1 (<65 years old) and Group 2 (≥65 years old). The primary endpoint was the assessment of the overall, bilateral, and unsuccessful SLN mapping in the two groups. Secondary outcomes were the …
On the tensor degree of finite groups
2013
We study the number of elements $x$ and $y$ of a finite group $G$ such that $x \otimes y= 1_{_{G \otimes G}}$ in the nonabelian tensor square $G \otimes G$ of $G$. This number, divided by $|G|^2$, is called the tensor degree of $G$ and has connection with the exterior degree, introduced few years ago in [P. Niroomand and R. Rezaei, On the exterior degree of finite groups, Comm. Algebra 39 (2011), 335--343]. The analysis of upper and lower bounds of the tensor degree allows us to find interesting structural restrictions for the whole group.
Cabut, a C2H2 zinc finger transcription factor, is required during Drosophila dorsal closure downstream of JNK signaling.
2005
AbstractDuring dorsal closure, the lateral epithelia on each side of the embryo migrate dorsally over the amnioserosa and fuse at the dorsal midline. Detailed genetic studies have revealed that many molecules are involved in this epithelial sheet movement, either with a signaling function or as structural or motor components of the process. Here, we report the characterization of cabut (cbt), a new Drosophila gene involved in dorsal closure. cbt is expressed in the yolk sac nuclei and in the lateral epidermis. The Cbt protein contains three C2H2-type zinc fingers and a serine-rich domain, suggesting that it functions as a transcription factor. cbt mutants die as embryos with dorsal closure …
Correlation between cell line chemosensitivity and protein expression pattern as new approach for the design of targeted anticancer small molecules
2022
BACKGROUND AND RATIONALE: Over the past few decades, several databases with a significant amount of biological data related to cancer cells and anticancer agents (e.g.: National Cancer Institute database, NCI; Cancer Cell Line Encyclopedia, CCLE; Genomic and Drug Sensitivity in Cancer portal, GDSC) have been developed. The huge amount of heterogeneous biological data extractable from these databanks (among all, drug response and protein expression) provides a real foundation for predictive cancer chemogenomics, which aims to investigate the relationships between genomic traits and the response of cancer cells to drug treatment with the aim to identify novel therapeutic molecules and targets…
Glutathione in Cancer Cell Death
2011
Glutathione (L-γ-glutamyl-L-cysteinyl-glycine; GSH) in cancer cells is particularly relevant in the regulation of carcinogenic mechanisms; sensitivity against cytotoxic drugs, ionizing radiations, and some cytokines; DNA synthesis; and cell proliferation and death. The intracellular thiol redox state (controlled by GSH) is one of the endogenous effectors involved in regulating the mitochondrial permeability transition pore complex and, in consequence, thiol oxidation can be a causal factor in the mitochondrion-based mechanism that leads to cell death. Nevertheless GSH depletion is a common feature not only of apoptosis but also of other types of cell death. Indeed rates of GSH synthesis and…
Propiedades psicométricas del cuestionario de afronta¬miento al estrés para pacientes oncológicos (CAEPO)
2017
Los objetivos del estudio fueron: 1) analizar la estructura factorial de la escala CAEPO mediante análisis factorial exploratorio y confirmatorio; 2) estimar la consistencia interna de los factores; 3) describir la distribución de los factores; 4) analizar las diferencias de medias de las estrategias de afrontamiento entre hombres y mujeres. El Cuestionario de Afrontamiento al Estrés para Pacientes Oncológicos (CAEPO) de González (2004) fue aplicado a 148 pacientes oncológicos. Se sugiere reducir la escala a 35 ítems. Se encontró una estructura de cuatro factores correlacionados con consistencias internas de adecuadas a altas. La distribución de los factores se ajustó a una curva normal y n…