Search results for "C3"
showing 10 items of 1295 documents
Neuroimaging and electrophysiology meet invasive neurostimulation for causal interrogations and modulations of brain states.
2020
Deep brain stimulation (DBS) has developed over the last twenty years into a highly effective evidenced-based treatment option for neuropsychiatric disorders. Moreover, it has become a fascinating tool to provide illustrative insights into the functioning of brain networks. New anatomical and pathophysiological models of DBS action have accelerated our understanding of neurological and psychiatric disorders and brain functioning. The description of the brain networks arose through the unique ability to illustrate long-range interactions between interconnected brain regions as derived from state-of-the-art neuroimaging (structural, diffusion, and functional MRI) and the opportunity to record…
EEG and MEG primers for tracking DBS network effects
2020
Deep brain stimulation (DBS) is an effective treatment method for a range of neurological and psychiatric disorders. It involves implantation of stimulating electrodes in a precisely guided fashion into subcortical structures and, at a later stage, chronic stimulation of these structures with an implantable pulse generator. While the DBS surgery makes it possible to both record brain activity and stimulate parts of the brain that are difficult to reach with non-invasive techniques, electroencephalography (EEG) and magnetoencephalography (MEG) provide complementary information from other brain areas, which can be used to characterize brain networks targeted through DBS. This requires, howeve…
Euro Area Structural Convergence? A Multi-Criterion Cluster Analysis
2015
Abstract This paper proposes a classification of the old member countries of the euro area in a structural data rich environment and run a convergence analysis using the same framework. First, we use a clustering approach and identify two structurally distinct clusters of countries that are not modified between 1999 and 2012: the South Countries Group (SCG) – composed of Greece, Italy, Portugal and Spain – and the Other Countries Group (OCG). Second, we propose a convergence metrics and reach three key findings: (i) increase over time of the between-clusters׳ dispersion; (ii) diverging demographics and innovation performance into the OCG, and (iii) an unfortunate convergence towards high la…
Mode of Delivery and the Effectiveness of Foreign Aid: The Example of Missionary Work
2010
Conventional development aid, typically a service from government to government, has been a relatively poor determinant of economic growth or human development in developing countries. In this paper we test whether a distinctly grass-roots delivery mode, as is the case with missionary work, leads to a more effective dispersion of foreign aid. In addition to its mode of delivery, missionary work is also of interest as there is a known positive correlation between the growth rate of Christianity and economic development. We estimate the economic growth impacts of development aid versus missionary work variables by using empirical data from 119 countries and discuss several explanations for ou…
A Structural Theorem for Metric Space Valued Mappings of Φ-bounded Variation
2009
In this paper we introduce the notion of $\Phi$-bounded variation for metric space valued mappings defined on a subset of the real line. Such a notion generalizes the one for real functions introduced by M. Schramm, and many previous generalized variations. We prove a structural theorem for mappings of $\Phi$-bounded variation. As an application we show that each mapping of $\Phi$-bounded variation defined on a subset of $\mathbb{R}$ possesses a $\Phi$-variation preserving extension to the whole real line.
Comparing weak versions of separability
2012
Our aim is to investigate spaces with sigma-discrete and meager dense sets, as well as selective versions of these properties. We construct numerous examples to point out the differences between these classes while answering questions of Tkachuk [30], Hutchinson [17] and the authors of [8].
Aproximación psicopatológica a El Quijote (según la nosología psiquiátrica actual)
2003
Se analiza la psicopatología de Don Quijote y se revisan los estudios previos sobre el personaje, tanto desde la perspectiva médica como la literaria. Considerando el enfoque de la nosología psiquiátrica actual, Don Quijote cumpliría criterios para un Trastorno Delirante y esto se argumenta en base a la génesis del delirio, la sintomatología y los rasgos formales del delirio. Asimismo, se propone el diagnóstico de Trastorno Psicótico Compartido para la pareja protagonista (Don Quijote y Sancho).
Chronic fluoxetine treatment in middle-aged rats induces changes in the expression of plasticity-related molecules and in neurogenesis
2012
Abstract Background Antidepressants promote neuronal structural plasticity in young-adult rodents, but little is known of their effects on older animals. The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) may mediate these structural changes through its anti-adhesive properties. PSA-NCAM is expressed in immature neurons and in a subpopulation of mature interneurons and its expression is modulated by antidepressants in the telencephalon of young-adult rodents. Results We have analyzed the effects of 14 days of fluoxetine treatment on the density of puncta expressing PSA-NCAM and different presynaptic markers in the medial prefrontal cortex, hippocampus and amygdala of mi…
Up and Down States During Slow Oscillations in Slow-Wave Sleep and Different Levels of Anesthesia
2021
Slow oscillations are a pattern of synchronized network activity generated by the cerebral cortex. They consist of Up and Down states, which are periods of activity interspersed with periods of silence, respectively. However, even when this is a unique dynamic regime of transitions between Up and Down states, this pattern is not constant: there is a range of oscillatory frequencies (0.1–4 Hz), and the duration of Up vs. Down states during the cycles is variable. This opens many questions. Is there a constant relationship between the duration of Up and Down states? How much do they vary across conditions and oscillatory frequencies? Are there different sub regimes within the slow oscillation…
How Many Clocks, How Many Times? On the Sensory Basis and Computational Challenges of Circadian Systems
2018
A vital task for every organism is not only to decide what to do but also when to do it. For this reason, “circadian clocks” have evolved in virtually all forms of life. Conceptually, circadian clocks can be divided into two functional domains; an autonomous oscillator creates a ~24 h self-sustained rhythm and sensory machinery interprets external information to alter the phase of the autonomous oscillation. It is through this simple design that variations in external stimuli (for example, daylight) can alter our sense of time. However, the clock’s simplicity ends with its basic concept. In metazoan animals, multiple external and internal stimuli, from light to temperature and even metaboli…