Search results for "CAG"
showing 10 items of 492 documents
Size-selective incorporation of DNA nanocages into nanoporous antimony-doped tin oxide materials.
2011
A conductive nanoporous antimony-doped tin oxide (ATO) powder has been prepared using the sol-gel method that contains three-dimensionally interconnected pores within the metal oxide and highly tunable pore sizes on the nanoscale. It is demonstrated that these porous materials possess the capability of hosting a tetrahedral-shaped DNA nanostructure of defined dimensions with high affinity. The tunability of pore size enables the porous substrate to selectively absorb the DNA nanostructures into the metal oxide cavities or exclude them from entering the surface layer. Both confocal fluorescence microscopy and solution FRET experiments revealed that the DNA nanostructures maintained their int…
Exploiting the Pleiotropic Antioxidant Effects of Established Drugs in Cardiovascular Disease.
2015
Cardiovascular disease is a leading cause of death and reduced quality of life worldwide. Arterial vessels are a primary target for endothelial dysfunction and atherosclerosis, which is accompanied or even driven by increased oxidative stress. Recent research in this field identified different sources of reactive oxygen and nitrogen species contributing to the pathogenesis of endothelial dysfunction. According to lessons from the past, improvement of endothelial function and prevention of cardiovascular disease by systemic, unspecific, oral antioxidant therapy are obviously too simplistic an approach. Source- and cell organelle-specific antioxidants as well as activators of intrinsic antiox…
Effets de la nutrition et du génotype de la plante sur la résistance de Medicago truncatula à Aphanomyces euteiches
2016
SPEIPMUBAGROSUPINRA; Dans la nature, les plantes ont la capacité de mettre en oeuvre des réponses immunitaires pour faire face aux microorganismes pathogènes. Cependant, ces réponses de défense sont coûteuses en énergie et conduisent la plante à détourner une partie de ces ressources destinées à d’autres traits de vie comme la croissance. Ce compromis défense/croissance est largement conditionné par la disponibilité extérieure en nutriments. Afin de mieux décrire et comprendre les liens entre la nutrition et la défense, nous avons analysé l’impact de la nutrition azotée et l’effet de la variabilité génétique végétale sur la capacité de la légumineuse Medicago truncatula à résister à un agen…
Effects of plant nutrition and genotype on Medicago truncatula defense responses against Aphanomyces euteiches
2014
SPEIPM; International audience
Interazioni metropolitane
2020
Difficile presentare la ricerca di Giovanni Battista Cocco e Adriano Dessi escludendo quanto è accaduto negli ultimi mesi in seguito alla pandemia. Se si dovesse procedere nella riflessione senza tenere conto della diffusione del virus SARS-Cov-2 e della infezione Covid-19, ne scaturirebbe un quadro distorto e forse si apprezzerebbe solo in parte il lavoro dei due ricercatori che, osservando una specifica condizione metropolitana, ne palesano le peculiarità e, utilizzando il progetto di architettura come strumento di indagine, le potenzialità. Perché richiamare la pandemia se il volume è stato concluso poco prima che la sciagura si propagasse? Perché le conseguenze del virus hanno messo in …
Resistenza a taglio di un'argilla a scaglie compattata non satura
2011
La tesi di dottorato ha sviluppato lo studio degli effetti della struttura e della suzione sulla rigidezza e sulla resistenza a taglio di un'argilla a scaglie compattata non satura. Le caratteristiche microstrutturali dell'argilla compattata sono state studiate mediante osservazioni al SEM e prove MIP. Sono state esaminate le modifiche microstrutturali derivanti dalla saturazione, a volume costante e in condizioni di rigonfiamento libero, e dalla riconsolidazione dopo intensi trattamenti di destrutturazione (argilla ricostituita). Le proprietà meccaniche dell'argilla a scaglie compattata non satura sono state indagate mediante prove di compressione edometrica e di compressione triassiale a …
Tra incantamento e phobos. Alcuni esempi sugli effetti dell'aulos nei dialoghi di Platone e nella catarsi tragica.
2008
Il potere dell‟aulos e i suoi effetti sull‟animo erano così emblematici per i Greci da far loro trasformare lo strumento e le sue sonorità in una metafora di persuasione, come si riscontra in alcuni dialoghi di Platone. Da un altro punto di vista, però, l‟aulos fu anche uno strumento „perturbante‟, come appare ad esempio nella tragedia. In tale contesto esso sembra operare sulle paure (phobos) e le insicurezze dei personaggi tragici, e talora addirittura condurre agli sviluppi conclusivi della performance teatrale. Per quel che riguarda invece l'uditorio in teatro, l‟aulos può aver giocato un ruolo nello sviluppo della catarsi, in quanto gli spettatori potevano essere in grado di collegare …
Surface modification of AISI-304 steel by ZnO synthesis using cathodic cage plasma deposition
2021
Abstract Zinc-oxide (ZnO), a solid lubricant coating, can increase the wear resistance of steels by working as a self-lubricant. In this study, ZnO film is synthesized using the cathodic cage plasma deposition (CCPD) technique, using galvanized steel cathodic cage (steel cage with zinc coating). The effect of gas composition (H2 is added in Ar-O2) is investigated to optimize the film properties. The surface hardness is increased more than twice in each processing condition. The deposited film shows ZnO phases for samples treated with low hydrogen contents and a combination of ZnO and magnetite phase (Fe3O4) with higher hydrogen contents. The thickness of film reduced from 1.28 μm to 0.5 μm …
Incretins, Pregnancy, and Gestational Diabetes
2015
The number of pregnant women affected by gestational diabetes mellitus (GDM) is increasing among Caucasians, and East Asians. GDM also increases the risk for later advent of type 2 diabetes mellitus (T2DM), obesity, and cardiovascular disease in both women and their offspring. The underlying mechanism of GDM is not fully elucidated. Incretins such as glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), have been suggested to have a role in maternal metabolism and weight as well as fetal growth. These hormones might be implicated in mechanisms that compensate for the increment in glycemia and insulin resistance seen during pregnancy, while other factors, such a…
GLP 1 receptor agonists, glycemic variability, oxidative stress and acute coronary syndrome
2020
Abstract Glycemic variability (GV) has been recently described as an independent cardiovascular risk factor in patients with acute coronary syndrome (ACS). Also, new findings suggest that GV plays an important role in the development of complications related to impaired glucose metabolism and oxidative stress. On the other hand, although treatment for diabetes can reduce HbA1c in a similar extent their effectiveness over GV can be radically different. Patients in the acute setting of a coronary syndrome should be strictly monitorized to maintain glucose within recommended values; avoiding values lower than 90 mg/dL (5 mmol/L) and higher than 180 mg/dL (10 mmol/L). Also, evidence suggests th…