Search results for "CANCERS"

showing 10 items of 276 documents

Insulin resistance and hyperandrogenism drive steatosis and fibrosis risk in young females with PCOS

2017

Background and aims Nonalcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) recognize obesity and insulin resistance (IR) as common pathogenic background. We assessed 1) whether PCOS is a risk factor for steatosis, and 2) the impact, in PCOS patients, of IR and hyperandrogenism on steatosis and fibrosis. Methods We considered 202 consecutive Italian PCOS nondiabetic patients and 101 age-matched controls. PCOS was diagnosed applying the Rotterdam diagnostic criteria. Steatosis was diagnosed if hepatic steatosis index (HSI) >36, while fibrosis by using the FIB-4 score. As surrogate estimate of insulin sensitivity we considered the insulin sensitivity index (ISI). Free an…

0301 basic medicineSteatosisendocrine system diseasesPhysiologylcsh:MedicinePathology and Laboratory MedicineBiochemistryBody Mass IndexCytopathology0302 clinical medicineEndocrinologyNon-alcoholic Fatty Liver DiseaseRisk FactorsNonalcoholic fatty liver diseaseMedicine and Health SciencesInsulinlcsh:ScienceMultidisciplinaryLiver DiseasesFatty liverMiddle AgedPolycystic ovaryLipidsCholesterolOncologyPhysiological Parameters030211 gastroenterology & hepatologyFemalePolycystic Ovary SyndromeResearch ArticleAdultmedicine.medical_specialtyGastroenterology and Hepatology03 medical and health sciencesInsulin resistanceInternal medicinemedicineHumansObesityRisk factorTriglyceridesDiabetic Endocrinologybusiness.industryFree androgen indexHyperandrogenismCholesterol HDLBody Weightlcsh:RCancers and NeoplasmsBiology and Life Sciencesmedicine.diseaseFibrosisHormonesFatty Liver030104 developmental biologyEndocrinologyAnatomical Pathologylcsh:QSteatosisInsulin ResistancebusinessHyperandrogenismGynecological TumorsDevelopmental Biologyinsulin resistance PCOS
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Global surveillance of trends in cancer survival 2000-14 (concord-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18…

2018

Eser, Sultan (Balikesir Author)

0301 basic medicineUniversal Health Coveragepopulation-based registriesRelative SurvivalSettore MED/42 - Igiene Generale E ApplicataCancer -- TreatmentHumans; Neoplasms; Population Surveillance; Registries; Survival Rate; Medicine (all)0302 clinical medicineNeoplasmsRegistriescancer survivaleducation.field_of_studyRelative survivalMedicine (all)EPICENEGeneral Medicine3. Good healthSurvival Ratetrend030220 oncology & carcinogenesisPopulation SurveillancePublic-Healthcancer surveillanceLiver cancersurvival ; cancer registry ; CONCORD-3CureChildhood-Cancermedicine.medical_specialtypopulation-based cancer registriesWomens CancersPopulationMedicine (all)cancer survival population-based cancer registriesSocio-culturaleUnited-StatessurvivalArticle03 medical and health sciencesBreast cancerCancer epidemiologymedicineHumansNordic-CountriesCancer -- MortalityeducationSurvival rateCancer preventionAlternative Approachbusiness.industryPublic healthCancerCancer -- Patients -- Long-term caremedicine.disease030104 developmental biologyHigh-Income Countries[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologiebusinessDemography
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ISL1 is a major susceptibility gene for classic bladder exstrophy and a regulator of urinary tract development

2017

AbstractPreviously genome-wide association methods in patients with classic bladder exstrophy (CBE) found association with ISL1, a master control gene expressed in pericloacal mesenchyme. This study sought to further explore the genetics in a larger set of patients following-up on the most promising genomic regions previously reported. Genotypes of 12 markers obtained from 268 CBE patients of Australian, British, German Italian, Spanish and Swedish origin and 1,354 ethnically matched controls and from 92 CBE case-parent trios from North America were analysed. Only marker rs6874700 at the ISL1 locus showed association (p = 2.22 × 10−08). A meta-analysis of rs6874700 of our previous and prese…

0301 basic medicinemedicine.medical_specialtyPathologyMesenchymeUrinary systemOrganogenesisLIM-Homeodomain ProteinsLocus (genetics)030105 genetics & heredityBiologyPolymorphism Single Nucleotidebladder extrophyArticlePronephrosMesoderm03 medical and health sciencesMiceBEEC bladder extrophy urinary tract development ISL1GenotypemedicineAnimalsHumansProtein IsoformsGenetic Predisposition to DiseaseBEECUrinary TractGeneZebrafishGeneticsMultidisciplinaryBladder ExstrophyGene Expression Regulation DevelopmentalISL1medicine.diseaseEmbryo Mammalianurinary tract developmentBladder exstrophy030104 developmental biologymedicine.anatomical_structureReconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10]LarvaISL1Medical geneticsFemaleTranscription FactorsRare cancers Radboud Institute for Health Sciences [Radboudumc 9]Scientific Reports
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Treatment challenges in and outside a network setting: Head and neck cancers.

2019

Head and neck cancer (HNC) is a rare disease that can affect different sites and is characterized by variable incidence and 5-year survival rates across Europe. Multiple factors need to be considered when choosing the most appropriate treatment for HNC patients, such as age, comorbidities, social issues, and especially whether to prefer surgery or radiation-based protocols. Given the complexity of this scenario, the creation of a highly specialized multidisciplinary team is recommended to guarantee the best oncological outcome and prevent or adequately treat any adverse effect. Data from literature suggest that the multidisciplinary team-based approach is beneficial for HNC patients and lea…

0301 basic medicinemedicine.medical_specialtySocio-culturaleSocial issuesMultidisciplinary team03 medical and health sciencesTherapeutic approach0302 clinical medicineRare DiseasesMultidisciplinary approachmedicineHumansAdverse effectIntensive care medicineHead and neck cancerReferral and ConsultationPatient Care TeamEuropean reference networks joint action of rare cancers ; Head and neck cancer ; Multidisciplinary team ; Rare diseasebusiness.industryHead and Neck NeoplasmHead and neck cancerEuropean reference networks joint action of rare cancersGeneral MedicineMultidisciplinary teammedicine.diseaseEurope030104 developmental biologyClinical researchOncologyHead and Neck Neoplasms030220 oncology & carcinogenesisEuropean reference networks joint action of rare cancerSurgerybusinessEuropean reference networks joint action of rare cancers; Head and neck cancer; Multidisciplinary team; Rare disease; Surgery; OncologyRare diseaseDelivery of Health CareRare diseaseHumanEuropean journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
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Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement

2018

Tissue-specific effects of 17 beta-estradiol are delivered via both estrogen receptors and microRNAs (miRs). Menopause is known to affect the whole-body fat distribution in women. This investigation aimed at identifying menopause-and hormone replacement therapy (HRT)-associated miR profiles and miR targets in subcutaneous abdominal adipose tissue and serum from the same women. A discovery phase using array technology was performed in 13 women, including monozygotic twin pairs discordant for HRT and premenopausal young controls. Seven miRs, expressed in both adipose tissue and serum, were selected for validation phase in 34 women from a different cohort. An age/menopause-related increase of …

0301 basic medicinevaihdevuodetmedicine.medical_treatmentmenopauseAdipose tissueEstrogen receptorMonozygotic twinTHERAPYchemistry.chemical_compoundestrogen therapyAdipocyteTUMOR-SUPPRESSORADIPOCYTE DIFFERENTIATIONmicroRNAestrogeenihoitota3141miR-19a-3pHormone replacement therapy (menopause)ta31423142 Public health care science environmental and occupational healthmicroRNAsadipose tissueMenopauseOncologyhormonihoitoSKELETAL-MUSCLEESTROGEN-RECEPTOR-ALPHASTEM-CELLSResearch PaperEXPRESSIONestrogeenitmedicine.medical_specialtyBODY-COMPOSITION3122 Cancersrasvakudokset03 medical and health sciencesInternal medicinemedicineBREAST-CANCERbusiness.industryagingmedicine.diseasehormonitMONOZYGOTIC TWIN PAIRSikääntyminen030104 developmental biologyEndocrinologychemistrybusinessEstrogen receptor alphaHormoneOncotarget
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Prostate cancer incidence and mortality in the Baltic states, Belarus, the Russian Federation and Ukraine

2019

BackgroundProstate cancer incidence varies internationally largely attributable to differences in prostate-specific antigen (PSA) use. The aim of this study was to provide the most recent detailed international epidemiological comparison of prostate cancer incidence and mortality in six north-eastern European countries (Belarus, Estonia, Latvia, Lithuania, the Russian Federation and Ukraine).MethodsThe number of incident prostate cancer cases was obtained from the countries national cancer registries. Prostate cancer mortality and corresponding population data were extracted from the WHO Mortality Database. Age-specific and age-standardised incidence and mortality rates were calculated (Eur…

AdultBaltic StatesMaletrendsmedicine.medical_specialtyRepublic of BelarusEpidemiology030232 urology & nephrologyPrevalenceRussia03 medical and health sciencesProstate cancer0302 clinical medicineProstateSyöpätaudit - CancersEpidemiologymedicineHumans1506AgedOriginal ResearchAged 80 and overProstate cancerbusiness.industryIncidenceIncidence (epidemiology)Mortality rateProstatic NeoplasmsCancerGeneral MedicineMiddle Agedmedicine.diseasemortality1692Prostate-specific antigenmedicine.anatomical_structure030220 oncology & carcinogenesisincidencePSA uptakeUkrainebusinessDemography
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Cancer in children and adolescents in Europe: Developments over 20 years and future challengers

2006

This special issue contains 18 articles describing population-based analyses of incidence and survival for cancer among children and adolescents in Europe over the period 1978-1997. The analyses were derived from the large database of the ACCIS project (Automated Childhood Cancer Information System), which was built through collaboration of 62 population-based cancer registries in 19 European countries. Data on 88,465 cancers in children and 15,369 in adolescents (age 15-19 yrs) were included in the various analyses, making this the largest database on cancer in these age-groups in the world. National data were grouped into five European regions to allow comparisons of incidence and surviva…

AdultCancer ResearchPediatricsmedicine.medical_specialtycancer incidenceTime FactorsAdolescentDatabases FactualPopulationSDG 3 - Good Health and Well-beingNeoplasmsmedicineHumansRegistriesMortalityeducationChildeducation.field_of_studycancer incidence; Childhood cancers - survival - time trendsbusiness.industryPublic healthIncidence (epidemiology)IncidenceConfoundingInfant NewbornCancerInfantmedicine.diseaseSurvival AnalysisEuropeOncologyEl NiñoData qualityChild PreschoolEtiologybusinessChildhood cancers - survival - time trendsDemography
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Unravelling the heterogeneity of soft tissue and bone sarcoma patients’ health-related quality of life: a systematic literature review with focus on …

2020

Contains fulltext : 229532.pdf (Publisher’s version ) (Open Access) Patients with sarcoma experience many physical and psychological symptoms, adversely affecting their health-related quality of life (HRQoL). HRQoL assessment is challenging due to the diversity of the disease. This review aims to unravel the heterogeneity of HRQoL of patients with sarcoma with regard to tumour location and to summarise the used measures in research. English-language literature from four databases published between January 2000 and April 2019 was reviewed. Studies that described adult sarcoma HRQoL outcomes were included and classified according to primary sarcoma location. Eighty-seven articles met the incl…

AdultCancer Researchmedicine.medical_specialtyConstitutional symptomsPopulationbone sarcomaSoft Tissue NeoplasmsReviewBone Sarcomalcsh:RC254-282Quality of lifeInternal medicineSurveys and QuestionnairesMedicineHumans1506educationeducation.field_of_studyOsteosarcomabusiness.industrySoft tissue sarcomaSarcomamedicine.diseaselcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogenshumanitieshealth-related quality of lifeSystematic reviewOncologypatient-reported outcomessoft tissue sarcomaQuality of LifeSarcomabusinessPsychosocialRare cancers Radboud Institute for Health Sciences [Radboudumc 9]ESMO Open
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Quality-of-Life Priorities in Patients with Thyroid Cancer : a Multinational European Organisation for Research and Treatment of Cancer Phase I Study

2016

Item does not contain fulltext BACKGROUND: The objectives of this study were to determine quality of life (QoL) issues that are relevant to thyroid cancer patients cross-culturally, and to identify those with highest relevance to them in addition to the more general issues covered by the core European Organisation for Research and Treatment of Cancer QoL questionnaire (EORTC QLQ-C30). METHODS: A systematic literature search provided a list of potentially relevant QoL issues to supplement the core questionnaire EORTC QLQ-C30, which is widely used in research and in care and addresses QoL issues relevant to all groups of cancer patients. A panel of experts revised this list, and thyroid cance…

AdultCross-Cultural ComparisonMalemedicine.medical_specialtyPathologyInternationalityEndocrinology Diabetes and MetabolismAlternative medicine030209 endocrinology & metabolism03 medical and health sciences0302 clinical medicineEndocrinologyQuality of lifeAdenocarcinoma FollicularMedicineHumansIn patientThyroid NeoplasmsVoluntary Health AgenciesThyroid cancerFatigueAgedNeoplasm StagingAged 80 and overbusiness.industryCancerRehabilitation VocationalMiddle Agedmedicine.diseaseCross-cultural studiesCombined Modality TherapyCarcinoma PapillaryhumanitiesPhase i studyCarcinoma NeuroendocrineEuropeMultinational corporationThyroid Cancer Papillary030220 oncology & carcinogenesisFamily medicineCarcinoma MedullaryQuality of LifeFemaleSelf ReportbusinessRare cancers Radboud Institute for Health Sciences [Radboudumc 9]
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Systematic review of the health-related quality of life issues facing adolescents and young adults with cancer

2017

Contains fulltext : 174665.pdf (Publisher’s version ) (Open Access) PURPOSE: For adolescents and young adults (AYAs), the impact of a cancer diagnosis and subsequent treatment is likely to be distinct from other age groups given the unique and complex psychosocial challenges of this developmental phase. In this review of the literature, we report the health-related quality of life (HRQoL) issues experienced by AYAs diagnosed with cancer and undergoing treatment. METHODS: MEDLINE, EMBASE, CINAHL, PsychINFO and the Cochrane Library Databases were searched for publications reporting HRQoL of AYAs. Issues generated from interviews with AYAs or from responses to patient reported outcome measures…

AdultGerontologymedicine.medical_specialtyAdolescentReviewYoung Adult03 medical and health sciences0302 clinical medicineQuality of life (healthcare)Age groupsNeoplasmsmedicinecancerHumansPatient reported outcome measures (PROMs)Patient Reported Outcome Measures030212 general & internal medicineYoung adultPsychiatryCancerQuality of Life ResearchHealth related quality of lifebusiness.industryPublic healthPublic Health Environmental and Occupational HealthCancermedicine.diseaseHealth-related quality of life (HRQoL)humanitiesadolescents and young adults (AYAs)030220 oncology & carcinogenesisQuality of LifeAdolescents and young adults (AYAs)health-related quality of life (HRQoL)businessPsychosocialpatient reported outcome measures (PROMs)Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
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