Search results for "CAPE"
showing 10 items of 1938 documents
On the polymer physics origins of protein folding thermodynamics
2016
A remarkable feature of the spontaneous folding of many small proteins is the striking similarity in the thermodynamics of the folding process. This process is characterized by simple two-state thermodynamics with large and compensating changes in entropy and enthalpy and a funnel-like free energy landscape with a free-energy barrier that varies linearly with temperature. One might attribute the commonality of this two-state folding behavior to features particular to these proteins (e.g., chain length, hydrophobic/hydrophilic balance, attributes of the native state) or one might suspect that this similarity in behavior has a more general polymer-physics origin. Here we show that this behavi…
Mechanically interlocked calix[4]arene dimers display reversible bond breakage under force.
2009
The physics of nanoscopic systems is strongly governed by thermal fluctuations that produce significant deviations from the behaviour of large ensembles1,2. Stretching experiments of single molecules offer a unique way to study fundamental theories of statistical mechanics, as recently shown for the unzipping of RNA hairpins3. Here, we report a molecular design based on oligo calix[4]arene catenanes—calixarene dimers held together by 16 hydrogen bridges—in which loops within the molecules limit how far the calixarene nanocapsules can be separated. This mechanically locked structure tunes the energy landscape of dimers, thus permitting the reversible rupture and rejoining of the individual n…
Collective properties of hydration: long range and specificity of hydrophobic interactions
1997
We report results of molecular dynamics (MD) simulations of composite model solutes in explicit molecular water solvent, eliciting novel aspects of the recently demonstrated, strong many-body character of hydration. Our solutes consist of identical apolar (hydrophobic) elements in fixed configurations. Results show that the many-body character of PMF is sufficiently strong to cause 1) a remarkable extension of the range of hydrophobic interactions between pairs of solute elements, up to distances large enough to rule out pairwise interactions of any type, and 2) a SIF that drives one of the hydrophobic solute elements toward the solvent rather than away from it. These findings complement re…
Heritage and the anti-city. Pizzo Sella in Palermo between modern ruins tourism and civic reappropriation
2022
Tutte le nozioni di patrimonio mettono in risonanza i valori della memoria e quelli dell'ambiente antropizzato, poiché entrambi sono intesi come duraturi. Riferendosi al caso iconico della collina di Pizzo Sella a Palermo, questo lavoro affronta il legame peculiare che in questo caso si esprime tra patrimonio, paesaggio e turismo. Per interrogarsi sul modo in cui tale legame segna il rapporto di una comunità con il suo passato, questo contributo si concentra su una nozione critica di patrimonio, inteso come sistema da riconoscere nel costruito dei territori del conflitto fra Stato e criminalità. Questi luoghi, a lungo sotto il controllo delle organizzazioni criminali mafiose, oggi sono prof…
Phycocyanobilin in solution – a solvent triggered molecular switch
2014
We present a computational investigation of the conformational response of phycocyanobilin (PCB) to the ability of solvents to form hydrogen bonds. PCB is the chromophore of several proteins in light harvesting complexes. We determine the conformational distributions in different solvents (methanol and hexamethylphosphoramide HMPT) by means of ab initio molecular dynamics simulations and characterize them via ab initio calculations of NMR chemical shift patterns. The computed trajectories and spectroscopic fingerprints illustrate that the energy landscape is very complex and exhibits various conformations of similar energy. We elucidate the strong influence of the solvent characteristics on…
Pastoral paths and the herding world: the routes of the shepherds from antiquity to modern age across the mountains of Sicily.
2014
Practices of development assistance and climate change mitigation in reshaping the Mozambican REDD+ strategy
2020
ABSTRACTThis paper studies how the practices of climate change governance and development assistance have reshaped the Reducing Emissions from Deforestation and Forest Degradation (REDD) process in Mozambique. We look at how the original goals of the Mozambican REDD+ strategy changed in the interplay of different governance-related practices, both those originating locally and nationally, and those coming from international organisations. The paper is based on the frameworks of multilevel governance and practice theory. We identify six combinations of practices that are relevant in the REDD+ programmes and projects. Three of them are incorporated in the general idea of sustainability, inclu…
Da “luoghi” di scarto a “spazi” di innovazione. Piani e politiche per i territori agricoli periurbani
2014
Concerning the new post-metropolitan area, the peri-urban territories, also due to the vagueness of their structural components, have become po-lisemical and plural places. From border areas between urban and rural functions, they have turned into integration places dealing with those two functions, getting out indeed their own plural identities. They are unsteady places, not even urban and no longer rural; border areas not only in spatial and administrative terms but also as regard a conceptual profile, which – such as a mosaic where settlement, agricultural and environmental systems interact and coexist- ask for clarification and mutuality reformulation between populated areas environment…
Comunicare per valorizzare: un progetto per il sito Archeologico di Eraclea Minoa
2019
Innovativi processi e linguaggi multimediali stanno trasformando i tradizionali sistemi di valorizzazione dei beni culturali. La pervasiva diffusione delle tecnologie digitali e virtuali ha infatti permesso l’elaborazione di strumenti e metodi particolarmente efficaci per la comunicazione e valorizzazione anche degli aspetti immateriali di oggetti e siti caratterizzati dal loro valore storico e dai significati culturali che trasmettono. In particolare la complessità e ricchezza d’implicazioni culturali proprie dei siti archeologici, richiedono oggi efficaci elementi di informazione e comunicazione per attivare coinvolgimento e piena consapevolezza nei visitatori, anche se in presenza di poc…
Good practices and actions for sustainable municipal solid waste management in the tourist sector
2018
This paper deals with waste management in the tourism sector, specifically in the agro-tourism structures. Two regions of Romania and Italy have been considered as case studies in order to promote good practices and actions for sustainable municipal solid waste management. Specific criteria to adopt for the sustainable consumption of beverages and food and for the sustainable use of packaging of various types have been analyzed and suggested. The adoption of an indicator at the level of the single tourist structure has been proposed to help self-analysis that is aimed at setting the priorities of intervention for improving its environmental sustainability.