Search results for "CARRIERS"

showing 10 items of 391 documents

Efeitos da sustentabilidade e valor logístico nas relações entre empresas de transporte marítimo

2020

Resumen El objetivo de este trabajo fue analizar cómo la sostenibilidad (económica, social y ambiental), bajo el enfoque de triple línea base, afecta la calidad de servicio, el valor logístico y la satisfacción en empresas del sector marítimo. Se propone un modelo teórico que se contrasta con la información suministrada por una muestra de 50 responsables de empresas (transitarios, importadores y exportadores) en Panamá. La información se analiza mediante la estimación de regresión por mínimos cuadrados parciales, que permite confirmar el carácter multidimensional de la sostenibilidad y del valor logístico. Los resultados también confirman que las percepciones de los clientes sobre las inici…

Responsabilidad social empresarialrelaciones business to businessEconomicsStrategy and Management//vocabularies.unesco.org/thesaurus/concept585 [http]Calidad de servicioRelaciones business to businessSatisfactionInternational tradeSocial responsibilityshipping industry//id.loc.gov/authorities/subjects/sh87004890 [http]Crecimiento económicoEmbarque de mercancíaspráticas sustentáveisCompañías de navegaciónindústria marítimaComercio internacionalManagement of Technology and InnovationShipment of goods//vocabularies.unesco.org/thesaurus/concept16052 [http]//vocabularies.unesco.org/thesaurus/concept3534 [http]logistic valueMarketing//id.loc.gov/authorities/subjects/sh85081260 [http]//id.loc.gov/authorities/subjects/sh85127728 [http]Responsabilidad socialCommerce internationalPrácticas sosteniblesMarine resources conservationSostenibilidadqualidade de serviçoQ56 SustainabilitySustainabilitybusiness-to-business relationships//vocabularies.unesco.org/thesaurus/concept6828 [http]Transporte marítimosustainable practicesEmploymentEconomics and Econometricsdemand supply and congestion [R41 Transportation]//id.loc.gov/authorities/subjects/sh85121576 [http]Steamboat linesConservación de los recursos marinos//id.loc.gov/authorities/subjects/sh85121579 [http]lcsh:Businessvalor logísticoindustria marítima//vocabularies.unesco.org/thesaurus/concept11744 [http]EconomíaShippingComercio exteriorSatisfacciónTransporte acuáticoBusiness and International Management//id.loc.gov/authorities/subjects/sh2009000375 [http]Economic growth//vocabularies.unesco.org/thesaurus/concept682 [http]calidad de servicioEconómicasprácticas sosteniblesIndustria marítimarelações business to businessSocial responsibility of business//id.loc.gov/authorities/subjects/sh85040850 [http]Maritime transport//id.loc.gov/authorities/subjects/sh85020473 [http]quality of service//id.loc.gov/authorities/subjects/sh85117681 [http]CarriersValor logísticolcsh:HF5001-6182Empresas de transporteEmpleoFinance
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Preparation and characterization of lipid nanoparticles as potential carriers for ester prodrugs of flurbiprofen

2011

SOLID LIPID NANOPARTICLES FLURBIPROFEN ESTER PRODRUGS COLLOIDAL CARRIERSSettore CHIM/09 - Farmaceutico Tecnologico Applicativo
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Influence of Riboflavin Targeting on Tumor Accumulation and Internalization of Peptostar Based Drug Delivery Systems.

2020

Riboflavin carrier protein (RCP) and riboflavin transporters (RFVTs) have been reported to be highly overexpressed in various cancer cells. Hence, targeting RCP and RFVTs using riboflavin may enhance tumor accumulation and internalization of drug delivery systems. To test this hypothesis, butyl-based 3-arm peptostar polymers were synthesized consisting of a lysine core (10 units per arm) and a sarcosine shell (100 units per arm). The end groups of the arms and the core were successfully modified with riboflavin and the Cy-5.5 fluorescent dye, respectively. While in phosphate buffered saline the functionalized peptostars showed a bimodal behavior and formed supramolecular structures over tim…

SarcosinePolymersmedia_common.quotation_subjectRiboflavinLysineBiomedical EngineeringPharmaceutical ScienceBioengineeringRiboflavinchemistry.chemical_compoundIn vivoRiboflavin-carrier proteinMaterials TestingHumansInternalizationmedia_commonPharmacologyDrug CarriersChemistryLysineOrganic ChemistryMembrane Transport ProteinsBiological TransportSarcosineCarbocyaninesCancer cellDrug deliveryPC-3 CellsBiophysicsBiotechnologyBioconjugate chemistry
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Polyaspartamide-polylactide electrospun scaffolds for potential topical release of Ibuprofen.

2012

In this work, the production and characterization of electrospun scaffolds of the copolymer α,β-poly(N-2-hydroxyethyl)-DL-aspartamide-graft-polylactic acid (PHEA-g-PLA), proposed for a potential topical release of Ibuprofen (IBU), are reported. The drug has been chemically linked to PHEA-g-PLA and/or physically mixed to the copolymer before electrospinning. Degradation studies have been performed as a function of time in Dulbecco phosphate buffer solution pH 7.4, for both unloaded and drug-loaded scaffolds. By using an appropriate ratio between drug physically blended to the copolymer and drug-copolymer conjugate, a useful control of its release can be obtained. MTS assay on human dermal fi…

ScaffoldMaterials scienceMts assayCell SurvivalAdministration TopicalPolyestersBiomedical EngineeringBiocompatible MaterialsIbuprofenCell LineBiomaterialschemistry.chemical_compoundPolylactic acidPolymer chemistrymedicineCopolymerCell AdhesionHumansCell adhesionAspartic AcidDrug CarriersTissue ScaffoldsMetals and AlloysDermisAnalgesics Non-NarcoticFibroblastsIbuprofenElectrospinningChemical engineeringchemistryCeramics and Compositesmedicine.drugConjugateJournal of biomedical materials research. Part A
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Synthesis, characterization and foaming of PHEA-PLLA, a new graft copolymer for biomedical engineering

2014

Abstract In this study a chemical grafting procedure was set up in order to link high molecular weight poly L-lactic acid (PLLA) chains to the hydrophilic α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) backbone. A graft copolymer named PHEA-g-PLLA (or simply PHEA–PLLA) was obtained bearing a degree of derivatization of 1.0 mol.% of PLLA as grafted chain. This new hybrid derivative offers both the opportune crystallinity necessary for the production of scaffolds trough a thermally induced phase separation (TIPS) technique and the proper chemical reactivity to perform further functionalizations with bio-effectors and drugs. PHEA–PLLA porous scaffolds for tissue engineering applications were…

ScaffoldMaterials sciencePolyestersBioengineeringBiocompatible MaterialsScaffoldBiomaterialschemistry.chemical_compoundCrystallinityTissue engineeringCopolymerComposite materialPorosityDerivatizationDrug CarriersCalorimetry Differential ScanningTissue EngineeringTemperatureProteinsPolymer graftCharacterization (materials science)chemistryMechanics of MaterialsPoly-L-lactic acidThermally induced phase separationPorosityDerivative (chemistry)
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Novel dual-flow perfusion bioreactor for in vitro pre-screening of nanoparticles delivery: design, characterization and testing

2021

An advanced dual-flow perfusion bioreactor with a simple and compact design was developed and evaluated as a potential apparatus to reduce the gap between animal testing and drug administration to human subjects in clinical trials. All the experimental tests were carried out using an ad hoc Poly Lactic Acid (PLLA) scaffold synthesized via Thermally Induced Phase Separation (TIPS). The bioreactor shows a tunable radial flow throughout the microporous matrix of the scaffold. The radial perfusion was quantified both with permeability tests and with a mathematical model, applying a combination of Darcy's Theory, Bernoulli's Equation, and Poiseuille's Law. Finally, a diffusion test allowed to in…

ScaffoldMaterials sciencePolymersDiffusionNanoparticleBiocompatible MaterialsBioengineeringIn Vitro Techniques3D ScaffoldBioreactorsFluid dynamicsPolymeric fluorescent nanoparticlesBioreactorAnimalsHumansDual-flow perfusion bioreactorPorosityDrug CarriersSettore ING-IND/24 - Principi Di Ingegneria ChimicaTissue EngineeringTunable radial flowSettore ING-IND/34 - Bioingegneria IndustrialeGeneral MedicineMicroporous materialHagen–Poiseuille equationSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoPermeability (electromagnetism)Microscopy Electron ScanningNanoparticlesBiotechnologyBiomedical engineeringBioprocess and Biosystems Engineering
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Aggregation behavior of cationic nanohydrogel particles in human blood serum.

2014

For systemic siRNA delivery applications, well-defined drug carriers are required that guarantee stability for both carrier and cargo. Among various concepts progressing in market or final development, cationic nanohydrogel particles may serve as novel transport media especially designed for siRNA-in vivo experiments. In this work, the interaction of nanohydrogel particles with proteins and serum components was studied via dynamic light scattering in human blood serum as novel screening method prior to applications in vivo. The formation of larger aggregates mostly caused by charge interaction with albumin could be suppressed by nanogel loading with siRNA affording a neutral zeta potential …

SerumPolymers and PlasticsLightNanogelsBioengineeringNanotechnologyPolyethylene GlycolsBiomaterialsDynamic light scatteringIn vivoCationsMaterials ChemistryZeta potentialHumansPolyethyleneimineScattering RadiationRNA Small InterferingDrug CarriersHuman bloodChemistryAlbuminCationic polymerizationHydrogelsBiophysicsDrug carrierNanogelBiomacromolecules
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NOVEL AMPHIPHILIC COPOLYMERS BASED ON POLYASPARTAMIDE GRAFT WITH SQUALENE RESIDUES TO OBTAIN MICELLES AS COLLOIDAL DRUG CARRIERS.

2009

Settore CHIM/09 - Farmaceutico Tecnologico ApplicativoPHEA SQUALENE MICELLES DRUG CARRIERS.
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PREPARATION AND CHARACTERIZATION OF CURCUMIN-LOADED LIPID NANOPARTICLES WITH IMPROVED ANTI-CANCER THERAPEUTIC EFFICACY

2011

Settore CHIM/09 - Farmaceutico Tecnologico ApplicativoSOLID LIPID NANOPARTICLES CURCUMIN COLLOIDAL DRUG CARRIERS
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Multifunctional Cationic PeptoStars as siRNA Carrier: Influence of Architecture and Histidine Modification on Knockdown Potential.

2019

RNA interference provides enormous potential for the treatment of several diseases, including cancer. Nevertheless, successful therapies based on siRNA require overcoming various challenges, such as poor pharmacokinetic characteristics of the small RNA molecule and inefficient cytosolic accumulation. In this respect, the development of functional siRNA carrier systems is a major task in biomedical research. To provide such a desired system, the synthesis of 3-arm and 6-arm PeptoStars is aimed for. The different branched polypept(o)idic architectures share a stealth-like polysarcosine corona for efficient shielding and a multifunctional polylysine core, which can be independently varied in s…

Small RNAGene knockdownDrug CarriersPolymers and PlasticsChemistryCationic polymerizationBioengineering02 engineering and technology010402 general chemistry021001 nanoscience & nanotechnology01 natural sciencesIn vitro0104 chemical sciencesBiomaterialschemistry.chemical_compoundCytosolRNA interferencePolylysineMaterials ChemistryBiophysicsHistidineRNA Small Interfering0210 nano-technologyHistidineBiotechnologyMacromolecular bioscience
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