Search results for "CASS"
showing 10 items of 433 documents
La postura dell’Antonio Cassese «umanitarista» di fronte alla realtà dei conflitti armati: riflessioni a partire da alcuni scritti
2022
Il presente contributo intende ricostruire l’approccio scientifico di Antonio Cassese allo specifico settore del diritto internazionale umanitario, approccio che conferma alcuni tratti più generali del suo pensiero giuridico. La sensibilità del giurista verso la realtà politica, storica e sociale accompagna infatti la produzione scientifica anche in questo settore, contribuendo a tratteggiare la postura di studioso capace di comunicare con (e pungolare) gli Stati. Attraverso tre filoni di indagine (la regolamentazione dei conflitti armati interni; l’(in-)esistenza di meccanismi dedicati di controllo; la dicotomia tra divieti generali e divieti specifici in materia di armi), si dimostra come…
Gozos al glorioso S. Casiano, Obispo de Brison, Maestro de Escuel. y Mártir
1750
El full orlat Grav. xil. enmarcat de "S. Casiano Ob. de Brison Maest. de Escula. y M." El text del goig a dues col., separades per banda
Savstarpējās atzīšanas principa piemērošana un tā pārkāpuma attaisnošana preču brīvas aprites jomā Eiropas Savienībā
2019
Bakalaura darbā tiek aplūkotas problēmas, kas izriet no savstarpējās atzīšanas principa un Līguma par Eiropas Savienības darbību 34. panta nekonsekventā nošķīruma, kā arī tiek analizēta savstarpējās atzīšanas principa kā patstāvīga tiesību institūta pamatotība. Darba mērķis ir noskaidrot mijiedarbību starp savstarpējās atzīšanas principu un Līguma par Eiropas Savienības darbību 34. pantu, kā arī izpētīt savstarpējās atzīšanas principa kā patstāvīga tiesību institūta piemērošanas iespējamību. Lai to sasniegtu, autors darbā pēta savstarpējās atzīšanas principa vēsturisko izcelsmi, principa nepieciešamības pamatojumu preču brīvas aprites jomā un tā saturisko apjomu. Pētījuma rezultātā, autors …
Gozos al glorioso S. Casiano, Obispo de Brison, Maestro de Escuel. y Mártir.
El full orlat Grav. xil. enmarcat de "S. Casiano Ob. de Brison Maest. de Escula. y M." El text del goig a dues col., separades per banda
Gozos al clorioso [sic] San Casiano, Obispo de Brisòn, Maestro de Escuela, y Martir.
El full orlat Grav. xil. enmarcat de "S. Casiano Ob. de Brison Maest. de Escula. y M." El text del goig a dues col., separades per banda
Gozos al glorioso S. Casiano, Obispo de Brison, Maestro de Escuel. y Mártir.
El full orlat Grav. xil. enmarcat de "S. Casiano Ob. de Brison Maest. de Escula. y M." El text del goig a dues col., separades per banda
Direct determination of intracellular daunorubicin in intact confluent monolayers of AT1 prostate carcinoma cells using a multiwell–multilabel counter
2008
The cytostatic drug daunorubicin exerts its toxic action by intercalating into the DNA. The efficacy of daunorubicin depends on the intracellular amount in the tumor cell. Here we have evaluated the use of a multiwell-multilabel reader for the direct determination of the fluorescent cytostatic drug daunorubicin in a prostate carcinoma cell line (AT1 R-3327 Dunning prostate carcinoma cells) grown on 24-well plates. We present evidence that this simple fluorescent parameter is a good measure for the toxicologically relevant amount of the drug intercalated into the DNA and, therefore, is a good predictor for the drug's cytotoxicity. The amount of cationic cytostatics in a tumor cell is primari…
Identification of new P-glycoprotein inhibitors derived from cardiotonic steroids
2014
P-glycoprotein (ABCB1, MDR1) is capable of extruding chemotherapeutics outside the cell and its overexpression in certain cancer cells may cause failure of chemotherapy. Many attempts were carried out to identify potent inhibitors of this transporter and numerous compounds were shown to exert inhibitory effects in vitro, but so far none were able to make their way to the clinic due to serious complications. Natural compounds represent a great source of therapeutics, which are believed to be safe and effective. Therefore, we have screened a large library of naturally occurring cardiotonic steroids and their derivatives using high throughput flow cytometry. We were able to identify six compou…
Multiparametric evaluation of the cytoprotective effect of the Mangifera indica L. stem bark extract and mangiferin in HepG2 cells.
2012
Abstract Objective Mango (Mangifera indica L.) stem bark extract (MSBE) is a natural product with biological properties and mangiferin is the major component. This paper reported the evaluation of the protective effects of MSBE and mangiferin against the toxicity induced in HepG2 cells by tert-butyl hydroperoxide or amiodarone. Method Nuclear morphology, cell viability, intracellular calcium concentration and reactive oxygen species (ROS) production were measured by using a high-content screening multiparametric assay. Key findings MSBE and mangiferin produced no toxicity below 500 mg/ml doses. A marked recovery in cell viability, which was reduced by the toxicants, was observed in cells pr…
Vitamin E transport, membrane incorporation and cell metabolism: Is α-tocopherol in lipid rafts an oar in the lifeboat?
2010
International audience; Vitamin E is composed of closely related compounds, including tocopherols and tocotrienols. Studies of the last decade provide strong support for a specific role of alpha-tocopherol in cell signalling and the regulation of gene expression. It produces significant effects on inflammation, cell proliferation and apoptosis that are not shared by other vitamin E isomers with similar antioxidant properties. The different behaviours of vitamin E isomers might relate, at least in part, to the specific effects they exert at the plasma membrane. alpha-Tocopherol is not randomly distributed throughout the phospholipid bilayer of biological membranes, and as compared with other…