Search results for "CASS"

Rilievo di un parco urbano con integrazione delle tecniche GNSS, NRTK, Laser Scanner e MMS

2013

Questo articolo riassume l'esperienza dei ricercatori del Dipartimento di Ingegneria Civile, Ambientale, Aerospaziale, dei Materiali (DICAM) dell'Università di Palermo nell'ambito del rilievo di un parco urbano e la sperimentazione di strumenti, tecniche e metodi innovativi. Da piu di vent'anni il Parco d'Orleans, adiacente il campus Universitario di Palermo, rappresenta un laboratorio all'interno del quale effettuare sperimentazioni di alto livello scientifico. Recentemente, una parte di questo parco è stato intitolato alla memoria di Ninni Cassarà, vice questore della Polizia di Stato e collaboratore di Giovanni Falcone. Esso si estende lungo la parte della campagna palermitana che va dal…

Identification of novel mutations in the ABCA12 gene, c.1857delA and c.5653–5655delTAT, causing harlequin ichthyosis

2013

Abstract Harlequin ichthyosis (HI) is a severe autosomal recessive developmental disorder of the skin that is frequently but not always fatal in the first few days of life. In HI, mutations in both ABCA12 gene alleles must have a severe impact on protein function and most mutations are truncating. The presence of at least one nontruncating mutation (predicting a residual protein function) usually causes a less severe congenital ichthyosis (lamellar ichthyosis or congenital ichthyosiform erythroderma). Here we report on a girl with severe HI diagnosed by prenatal ultrasound at 33 5/7 week gestation. Ultrasound findings included ectropion, eclabium, deformed nose, hands and feet, joint contra…

Sezioni Unite Scenari 2016

2016

Analisi delle descisioni delle Sezioni Unite in tema di: notifica alla persona offesa nei procedimenti per stalking, di inammissibilità del ricorso per cassazione, di procura speciale del difensore nei casi di rinuncia all'impugnazione

Long-term expression of the human alpha1-antitrypsin gene in mice employing anionic and cationic liposome vector.

1997

The complete process of gene therapy involves three important steps: targeting, delivery, and gene expression. Since each step can be related to the pharmacological concept of affinity, bioavailability, and intrinsic capacity, this commentary examines, from this perspective, the efficiency of anionic and cationic liposomes as vectors for the in vivo gene transfer of the human alpha1-antitrypsin gene. Small liposomes represent the first generation of liposomes destined for the liver parenchymal cell. Although the final efficiency of gene transfer is low, we found that small liposomes are a kind of high-affinity hepatocyte-destined vector because the dose range for mediating the response is t…

Activity of Cordycepin From Cordyceps sinensis Against Drug-Resistant Tumor Cells as Determined by Gene Expression and Drug Sensitivity Profiling

2021

Cordycepin is one of the substantial components of the parasitic fungus Cordyceps sinensis as well as other Cordyceps species. It exerts various effects such as antimetastatic, antiinflammatory, antioxidant, and neuroprotective activities. Assorted studies revealed in vitro and in vivo anticancer influence of cordycepin and put forward its potential for cancer therapy. However, the role of multidrug resistance-associated mechanisms for the antitumor effect of cordycepin has not been investigated in great detail thus far. Therefore, we searched cordycepin’s cytotoxicity with regard to well-known anticancer drug resistance mechanisms, including ABCB1, ABCB5, ABCC1, ABCG2, EGFR, and TP53, and…

2015

Multidrug resistance is a prevailing phenomenon leading to chemotherapy treatment failure in cancer patients. In the current study two known cytotoxic pseudoguaianolide sesquiterpene lactones; neoambrosin (1) and damsin (2) that circumvent MDR were identified. The two cytotoxic compounds were isolated using column chromatography, characterized using 1D and 2D NMR, MS, and compared with literature values. The isolated compounds were investigated for their cytotoxic potential using resazurin assays and thereafter confirmed with immunoblotting and in silico studies. MDR cells overexpressing ABC transporters (P-glycoprotein, BCRP, ABCB5) did not confer cross-resistance toward (1) and (2), indic…

P-glycoprotein and its inhibition in tumors by phytochemicals derived from Chinese herbs

2011

P-glycoprotein belongs to the family of ATP-binding cassette (ABC) transporters. It functions in cellular detoxification, pumping a wide range of xenobiotic compounds, including anticancer drugs out of the cell. In cancerous cells, P-glycoprotein confers resistance to a broad spectrum of anticancer agents, a phenomenon termed multidrug resistance. An attractive strategy for overcoming multidrug resistance is to block the transport function of P-glycoprotein and thus increase intracellular concentrations of anticancer drugs to lethal levels. Efforts to identify P-glycoprotein inhibitors have led to numerous candidates, none of which have passed clinical trials with cancer patients due to the…

In Vitro Analysis of the Two-Component System MtrB-MtrA from Corynebacterium glutamicum▿ †

2007

ABSTRACT The two-component system MtrBA is involved in the osmostress response of Corynebacterium glutamicum . MtrB was reconstituted in a functionally active form in liposomes and showed autophosphorylation and phosphatase activity. In proteoliposomes, MtrB activity was stimulated by monovalent cations used by many osmosensors for the detection of hypertonicity. Although MtrB was activated by monovalent cations, they lead in vitro to a general stabilization of histidine kinases and do not represent the stimulus for MtrB to sense hyperosmotic stress.

Optical and near-infrared recombination lines of oxygen ions from Cassiopeia A knots

2008

Context. Fast-moving knots (FMK) in the Galactic supernova remnant Cassiopeia A consist mainly of metals and allow to study element production in supernovae and shock physics in great detail. Aims. We work out theoretically and suggest to observe previously unexplored class of spectral lines -- metal recombination lines in optical and near-infrared bands -- emitted by the cold ionized and cooling plasma in the fast-moving knots. Methods. By tracing ion radiative and dielectronic recombination, collisional $l$-redistribution and radiative cascade processes, we compute resulting oxygen, silicon and sulphur recombination line emissivities. It allows us to determine the oxygen recombination lin…

Fine-structure infrared lines from the Cassiopeia A knots

2008

Aims: Archival observations of infrared fine-structure lines of the young Galactic supernova remnant Cassiopeia A allow us to test existing models and determine the physical parameters of various regions of the fast-moving knots (FMKs), which are metal-dominated clouds of material ejected by the supernova explosion. Methods: The fluxes of the far-infrared [O i] and [O iii] lines are extracted from the previously unpublished archival ISO data. The archival Spitzer data are used to determine the fluxes of the O, Ne, Si, S, Ar and Fe ion fine-structure lines originating in the FMKs. The ratios of these line fluxes are used for the plasma diagnostics. We also determine the infrared line flux ra…