Search results for "CB"
showing 10 items of 647 documents
Involvement of CB1 and CB2 receptors in the modulation of cholinergic neurotransmission in mouse gastric preparations.
2007
Abstract While most of the studies concerning the role of cannabinoids on gastric motility have focused the attention on the gastric emptying in in vivo animal models, there is little information about the cannabinoid peripheral influence in the stomach. In addition, the functional features of CB2 receptors in the gastrointestinal tract have been poorly characterized. The purpose of the present study was to investigate the effects of cannabinoid drugs on the excitatory cholinergic and inhibitory non-adrenergic non-cholinergic (NANC) neurotransmission in mouse isolated gastric preparations. Intraluminal pressure from isolated whole stomach was recorded and mechanical responses induced by ele…
A guided Internet-delivered intervention for adjustment disorders
2021
© 2020 John Wiley & Sons, Ltd.Evidence of self-help interventions for adjustment disorder (AjD) is limited. This study aims at testing in a randomized controlled trial (RCT) the effectiveness of a disorder-specific, Internet-delivered cognitive–behavioural therapy (ICBT) intervention for AjD. Participants were randomly allocated to either an ICBT with brief weekly telephone support (n = 34) or a waiting list group (n = 34). Beck's inventories for depression and anxiety were used as primary outcomes. The secondary outcomes were AjD symptoms, post-traumatic growth, positive and negative affect, and quality of life. In all, 76.5% of the participants completed the intervention. Compared with th…
The endocannabinoid system controls key epileptogenic circuits in the hippocampus.
2006
SummaryBalanced control of neuronal activity is central in maintaining function and viability of neuronal circuits. The endocannabinoid system tightly controls neuronal excitability. Here, we show that endocannabinoids directly target hippocampal glutamatergic neurons to provide protection against acute epileptiform seizures in mice. Functional CB1 cannabinoid receptors are present on glutamatergic terminals of the hippocampal formation, colocalizing with vesicular glutamate transporter 1 (VGluT1). Conditional deletion of the CB1 gene either in cortical glutamatergic neurons or in forebrain GABAergic neurons, as well as virally induced deletion of the CB1 gene in the hippocampus, demonstrat…
AS Citadele banka finanšu darbības analīze salīdzinājumā ar Latvijas komercbanku nozares rādītājiem
2019
Bakalaura darba tēma ir “Citadele banka finanšu darbības analīze salīdzinājumā ar Latvijas komercbanku nozares rādītājiem”. Bakalaura darba mērķis ir veikt AS Citadele banka finanšu darbības analīzi un salīdzināt to ar Latvijas komercbanku nozares vidējiem rādītājiem, kā arī izdarīt secinājumus un sniegt priekšlikumus. Lai sasniegtu izvirzīto darba mērķi tika izpētīta teorētiskā informācija par banku nozari, tās vēsturi un banku raksturojošiem finanšu rādītājiem. Darbā tika izmantota deskriptīvā finanšu analīzes metode – horizontālā un vertikālā analīze, ekonomiskās analīzes metode – rādītāju aprēķināšana un salīdzinājums, kā arī monogrāfiskā metode. Kopējais bakalaura darba apjoms ir 60 la…
Effet de l'orientation des fibres des plis adjacents sur la résistance au délaminage en mode I pur = Effect of the fibre's orientation of adjacent pl…
2009
National audience; Ce travail concerne l'étude de l'effet de l'orientation des fibres des plis adjacents à la fissure dans une éprouvette DCB (Double Cantilever Beam) sur la résistance au délaminage en mode I pur. Afin d'isoler l'influence de l'orientation l'étude porte sur des stratifiés particuliers ayant tous les mêmes matrices de comportement global A B D. Les résultats expérimentaux montrent une grande variation de résistance au délaminage GIC et des courbes R selon l'orientation des plis situés de part et d'autre du plan de fissure. Une modélisation par éléments finis permet de mettre en évidence l'importance de l'état de contraintes locales et donc de l'endommagement au voisinage du …
Evidence for characteristic vascular patterns in solid tumours: quantitative studies using corrosion casts
1999
The vascular architecture of four different tumour cell lines (CaX, CaNT, SaS, HEC-1B) transplanted subcutaneously in mice was examined by means of microvascular corrosion casting in order to determine whether there is a characteristic vascular pattern for different tumour types and whether it differs significantly from two normal tissues, muscle and gut. Three-dimensional reconstructed scanning electron microscope images were used for quantitative measurements. Vessel diameters, intervessel and interbranch distances showed large differences between tumour types, whereas the branching angles were similar. In all tumours, the variability of the vessel diameters was significantly higher than …
Neuronal populations mediating the effects of endocannabinoids on stress and emotionality
2011
An adequate emotional response to stress is essential for survival and requires the fine-tuned regulation of several distinct neuronal circuits. Therefore, a precise control of these circuits is necessary to prevent behavioral imbalances. During the last decade, numerous investigations have evidenced that the endocannabinoid (eCB) system is able to crucially control stress coping. Its central component, the cannabinoid type 1 receptor (CB1 receptor), is located at the presynapse, where it is able to attenuate neurotransmitter release after its activation by postsynaptically produced and released eCBs. To date, the eCB system has been found to control the neurotransmitter release from severa…
Longitudinal heritability of childhood aggression
2016
The genetic and environmental contributions to the variation and longitudinal stability in childhood aggressive behavior were assessed in two large twin cohorts, the Netherlands Twin Register (NTR), and the Twins Early Development Study (TEDS; United Kingdom). In NTR, maternal ratings on aggression from the Child Behavior Checklist (CBCL) were available for 10,765 twin pairs at age 7, for 8,557 twin pairs at age 9/10, and for 7,176 twin pairs at age 12. In TEDS, parental ratings of conduct disorder from the Strength and Difficulty Questionnaire (SDQ) were available for 6,897 twin pairs at age 7, for 3,028 twin pairs at age 9 and for 5,716 twin pairs at age 12. In both studies, stability and…
Komercbanku kā finanšu sektora sastāvdaļas darbības raksturojums
2018
Autores analītiskā izpēte par komercbаnku darbību kā finanšu sektora sastāvdaļu ir sadalīta trīs daļās, kurās tiek raksturota finanšu liberalizācijas nozīme, analizēta Latvijas komercbanku darbība un apskatīta banku un tautsaimniecības attīstības savstarpējā mijiedarbība. Nοzīmīgu lοmu rеģiοnālajā еkοnοmikā rοd bаnku ѕаvѕtаrрējā kοnkurеnсе, ѕīvā сīņа, раr liеlāku tirguѕ dаļu un kliеntu рiеѕаiѕtīšаnu, аiz kuras, iеѕрējаmѕ, ѕlēрjаѕ bаnku аgrеѕīvа рοlitikа un kοnfidеnсiālаѕ mеtοdеѕ, kаѕ rеzultātā nοѕаkа kаtrаѕ bаnkаѕ рiеѕаiѕtītο kliеntu lοkа рlаšumu un tā nοturēšаnаi nерiесiеšаmο раkаlрοjumu klāѕtа ѕniеgšаnu. Dаrbа mērķiѕ – rаkѕturοt komercbаnku darbību kā finanšu sektora sastāvdaļu, izѕkаtοt …
Komercbanku loma ekonomikā
2017
Bakalaura darba tēma: Komercbanku loma ekonomikā. Tēma ir aktuāla, jo komercbankas ir gan privātpersonu, gan juridisko personu centrā un komercbankas ir nozīmīgas nodokļu maksātājas. Komercbanku loma ir mobilizēt finanšu resursus. Tās finansē dažādas tautsaimniecības nozares, nodrošinot īstermiņa, vidēja termiņa un ilgtermiņa aizdevumus. Pēc krīzes periodā bankas vairs neaizdod naudu „necaurspīdīgiem” uzņēmumiem. Uzņēmējiem kritiskāk ir jāizvērtē savu biznesa ideju potenciālu un pieejamos resursus biznesa ideju attīstībai. Vājā kreditēšanas aktivitāte ir saistāma gan ar uzņēmēju bažām par nākotni, gan arī ar lielo ēnu ekonomikas īpatsvaru, kas no kredītspējīgo uzņēmumu loka izslēdz vairāk n…