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RESEARCH PRODUCT
Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy
Bernat SoriaBernat SoriaAlejandro Martin-montalvoYolanda AguileraNuria Mellado-damasJavier López-beasIsabel Herrera-herreraEscarlata LópezJuan A. BarciaManuel Alvarez-doladoAbdelkrim HmadchaAbdelkrim HmadchaVivian Capilla-gonzálezsubject
0301 basic medicinecognitionmedicine.medical_treatmentneurocognitive sequelaeStem cellsBioinformaticsBrain cancer0302 clinical medicineCognitionOriginal ResearchCREBNeuroprotección:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Radiotherapy [Medical Subject Headings]Neurocognitive sequelaeNeuroprotectionneuroprotectionmedicine.symptomStem cellCélulas madreNeoplasias encefálicas:Diseases::Neoplasms::Neoplasms by Site::Nervous System Neoplasms::Central Nervous System Neoplasms::Brain Neoplasms [Medical Subject Headings]Brain tumorInflammationNeuroprotectionlcsh:RC321-57103 medical and health sciencesCellular and Molecular NeuroscienceRadioterapiastem cellsmedicinelcsh:Neurosciences. Biological psychiatry. Neuropsychiatry:Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Acyltransferases::Acetyltransferases::p300-CBP Transcription Factors::CREB-Binding Protein [Medical Subject Headings]radiotherapybrain cancerCogniciónRadiotherapybusiness.industryMesenchymal stem cellmedicine.diseaseequipment and suppliesIntranasal cell deliveryRadiation therapy030104 developmental biology:Anatomy::Cells::Stem Cells [Medical Subject Headings]Nasal administrationbusinessNeurocognitive030217 neurology & neurosurgeryintranasal cell deliveryNeurosciencedescription
Radiotherapy is a highly effective tool for the treatment of brain cancer. However, radiation also causes detrimental effects in the healthy tissue, leading to neurocognitive sequelae that compromise the quality of life of brain cancer patients. Despite the recognition of this serious complication, no satisfactory solutions exist at present. Here we investigated the effects of intranasal administration of human mesenchymal stem cells (hMSCs) as a neuroprotective strategy for cranial radiation in mice. Our results demonstrated that intranasally delivered hMSCs promote radiation-induced brain injury repair, improving neurological function. This intervention confers protection against inflammation, oxidative stress, and neuronal loss. hMSC administration reduces persistent activation of damage-induced c-AMP response element-binding signaling in irradiated brains. Furthermore, hMSC treatment did not compromise the survival of glioma-bearing mice. Our findings encourage the therapeutic use of hMSCs as a non-invasive approach to prevent neurological complications of radiotherapy, improving the quality of life of brain tumor patients.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-05-16 | Frontiers in Cellular Neuroscience |