Search results for "CD3 Complex"

showing 3 items of 43 documents

CD3 immunohistochemistry is helpful in the diagnosis of giant cell arteritis.

2018

Objective. To evaluate whether CD3 staining performed routinely on temporal artery biopsy specimens might improve the sensitivity of temporal artery biopsy in patients with biopsy-negative GCA. Methods. Two hundred and seventy biopsies were considered for this study, stained with haematoxylin and eosin and with an anti-CD3 antibody. Results. The addition of CD3 staining modified the sensibility and the specificity of the histologic examination in 89.47 and 95.00%, respectively, with a positive and negative predictive values of 97.00 and 79.78%. Conclusion. The addition of CD3 immunostaining to the classic histologic evaluation is accompanied by a significant increase in the sensibility with…

giant cell arteritiMalePhotomicrographyPathologymedicine.medical_specialtyCD3 ComplexBiopsyGiant Cell ArteritisHaematoxylin03 medical and health scienceschemistry.chemical_compound0302 clinical medicineRheumatologyRetrospective StudiePositive predicative valueBiopsymedicineHumansPharmacology (medical)030212 general & internal medicineAgedRetrospective Studies030203 arthritis & rheumatologyAged 80 and overmedicine.diagnostic_testEosinbusiness.industryBiomarkerMiddle Agedmedicine.diseaseCD3ImmunohistochemistryStainingTemporal ArteriesdiagnosiSettore MED/16 - ReumatologiaGiant cell arteritischemistryROC CurveAged; Aged 80 and over; Biomarkers; Biopsy; CD3 Complex; Female; Giant Cell Arteritis; Humans; Immunohistochemistry; Male; Middle Aged; Photomicrography; ROC Curve; Retrospective Studies; Temporal ArteriesImmunohistochemistryFemalebusinessImmunostainingBiomarkersHumanRheumatology (Oxford, England)
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Human Memory Th17 Cell Populations Change Into Anti-inflammatory Cells With Regulatory Capacity Upon Exposure to Active Vitamin D

2019

Autoimmune diseases are characterized by an aberrantly activated immune system, resulting in tissue damage and functional disability in patients. An important therapeutic goal is to restore the deregulated immunological balance between pro- A nd anti-inflammatory T cells. This imbalance is illustrated by elevated levels and activity of memory Th17 cell populations, such as Th17, Th1/Th17, and Th17.1 cells, in various autoimmune diseases. These cells are characterized by the chemokine receptor CCR6, RORC expression and production of IL-17A, IFNγ, and TNFα. Using rheumatoid arthritis (RA) as a model of autoimmune disease, we here demonstrate that pro-inflammatory memory CCR6+ Th cells can swi…

lcsh:Immunologic diseases. Allergy0301 basic medicineAdultMaleReceptors CCR6rheumatoid arthritisCD3 ComplexCD3CellImmunologyAnti-Inflammatory Agentschemical and pharmacologic phenomenavitamin DC-C chemokine receptor type 6Autoimmune DiseasesArthritis Rheumatoid03 medical and health sciencesChemokine receptor0302 clinical medicineImmune systemsynovial fluidRAR-related orphan receptor gammamedicineImmunology and AllergyHumansCells CulturedOriginal ResearchAutoimmune diseasebiologyChemistryTumor Necrosis Factor-alphaInterleukinsMiddle Agedmedicine.diseaseTreg030104 developmental biologymedicine.anatomical_structureImmunologybiology.proteinTh17 CellsTumor necrosis factor alphaFemaleTh17lcsh:RC581-607Immunologic Memory030215 immunologyFrontiers in Immunology
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Control of Murine Cytomegalovirus Infection by γδ T Cells

2015

Infections with cytomegalovirus (CMV) can cause severe disease in immunosuppressed patients and infected newborns. Innate as well as cellular and humoral adaptive immune effector functions contribute to the control of CMV in immunocompetent individuals. None of the innate or adaptive immune functions are essential for virus control, however. Expansion of γδ T cells has been observed during human CMV (HCMV) infection in the fetus and in transplant patients with HCMV reactivation but the protective function of γδ T cells under these conditions remains unclear. Here we show for murine CMV (MCMV) infections that mice that lack CD8 and CD4 αβ-T cells as well as B lymphocytes can control a MCMV i…

lcsh:Immunologic diseases. AllergyMuromegalovirusAdoptive cell transferCD3 ComplexT cellImmunologyPopulation-MicrobiologyMiceImmune systemT-Lymphocyte SubsetsMedizinische FakultätVirologyGeneticsmedicineAnimalsCytotoxic T cellddc:610educationlcsh:QH301-705.5Molecular BiologyMice Knockouteducation.field_of_studybiologyvirus diseasesHerpesviridae InfectionsFlow CytometryAdoptive TransferVirologyHigh-Throughput Screening AssaysMice Inbred C57BLmedicine.anatomical_structurelcsh:Biology (General)Immunologybiology.proteinParasitologyAntibodyStem celllcsh:RC581-607CD8Research ArticlePLOS Pathogens
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