6533b85bfe1ef96bd12bab1e
RESEARCH PRODUCT
CD3 immunohistochemistry is helpful in the diagnosis of giant cell arteritis.
Francesco CicciaAngelo FerranteGiuliana GugginoCarlo SalvaraniAlberto CavazzaAroldo Rizzosubject
giant cell arteritiMalePhotomicrographyPathologymedicine.medical_specialtyCD3 ComplexBiopsyGiant Cell ArteritisHaematoxylin03 medical and health scienceschemistry.chemical_compound0302 clinical medicineRheumatologyRetrospective StudiePositive predicative valueBiopsymedicineHumansPharmacology (medical)030212 general & internal medicineAgedRetrospective Studies030203 arthritis & rheumatologyAged 80 and overmedicine.diagnostic_testEosinbusiness.industryBiomarkerMiddle Agedmedicine.diseaseCD3ImmunohistochemistryStainingTemporal ArteriesdiagnosiSettore MED/16 - ReumatologiaGiant cell arteritischemistryROC CurveAged; Aged 80 and over; Biomarkers; Biopsy; CD3 Complex; Female; Giant Cell Arteritis; Humans; Immunohistochemistry; Male; Middle Aged; Photomicrography; ROC Curve; Retrospective Studies; Temporal ArteriesImmunohistochemistryFemalebusinessImmunostainingBiomarkersHumandescription
Objective. To evaluate whether CD3 staining performed routinely on temporal artery biopsy specimens might improve the sensitivity of temporal artery biopsy in patients with biopsy-negative GCA. Methods. Two hundred and seventy biopsies were considered for this study, stained with haematoxylin and eosin and with an anti-CD3 antibody. Results. The addition of CD3 staining modified the sensibility and the specificity of the histologic examination in 89.47 and 95.00%, respectively, with a positive and negative predictive values of 97.00 and 79.78%. Conclusion. The addition of CD3 immunostaining to the classic histologic evaluation is accompanied by a significant increase in the sensibility with a comparable specificity. The Author(s) 2018.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-01 | Rheumatology (Oxford, England) |