Search results for "CEDU"
showing 10 items of 2453 documents
Die Primärstabilität von manuell und roboterassistiert implantierten Hüftendoprothesenstielen: eine biomechanische Untersuchung an Kunstfemora
2004
AIM We investigated the initial stability of cementless stems implanted with robotic milling and conventional manual broaching. METHODS Proximally porous structured stems (G2, ESKA-Implants, Luebeck, Germany) were implanted into synthetic femora. In one group, the femoral cavity was prepared by a CT-based robot (CASPAR, URS-Ortho, Germany) with a high-speed milling head. In the other group, femora were rasped manually with broaches. The broaches had 1 mm proximal press-fit, the robotic cavities 1.5 mm. The implants were exposed to 15 000 loading cycles with 1 000 +/- 500 N. The direction of forces on the implant head were chosen to simulate stair climbing. Internal rotation and translation …
Oral Solid Dosage Form Disintegration Testing — The Forgotten Test
2014
Since its inception in the 1930s, disintegration testing has become an important quality control (QC) test in pharmaceutical industry, and disintegration test procedures for various dosage forms have been described by the different pharmacopoeias, with harmonization among them still not quite complete. However, because of the fact that complete disintegration does not necessarily imply complete dissolution, much more research has been focused on dissolution rather than on disintegration testing. Nevertheless, owing to its simplicity, disintegration testing seems to be an attractive replacement to dissolution testing as recognized by the International Conference on Harmonization guidelines, …
Articaine versus lidocaine inferior alveolar nerve block in posterior mandible implant surgeries: a randomized controlled trial
2023
Background: The aim of this study is to compare the effects of %4 articaine and %2 lidocaine on inferior alveolar nerve block (IANB) for implant surgery in the posterior mandible.Material and Methods: The patients who have inserted implants in the posterior mandible were divided into 2 groups for IANB: lidocaine and articaine. VAS = visual analog scale, pain during surgery and injection, lip numb-ness time, mandibular canal-implant apex distance, age, gender, bone density, implant number, release incision, adjacent teeth, and duration of surgery were analyzed using t-test, Mann-Whitney U test, Spearman's coefficient, and, Pearson's chi-squared test. This trial followed the recommendations o…
Crónica de la jurisprudencia del Comité Europeo de Derechos Sociales - 2020
2021
La presente crónica aborda un año crucial (2020) en el que la actividad del Comité Europeo de Derechos Sociales se ha enfrentado a la grave crisis provocada por la pandemia de la Covid-19. En este sentido, la jurisprudencia del Comité sobre el sistema de informes se ha centrado en un grupo temático particularmente afectado por dicha crisis (¿Empleo, formación e igualdad de oportunidades¿). Por otro lado, la jurisprudencia del Comité sobre el procedimiento de reclamaciones colectivas se ha visto especialmente reforzada, con ocasión de la resolución de quince importantes reclamaciones, por los nuevos perfiles en materia de lucha contra la brecha salarial de género y la representación de las m…
Stability of tacrolimus ophthalmic solution
2017
Purpose The stability of 0.3-mg/mL tacrolimus ophthalmic solution at different storage temperatures was studied. Methods A sterile ophthalmic solution of 0.3 mg/mL tacrolimus was prepared in triplicate under aseptic conditions by diluting tacrolimus in eye drops. Three aliquots of this solution were transferred into polypropylene bottles and stored at 25, 2–8, or −15 to −25 °C. Samples were collected immediately after preparation and at selected time points and assayed in triplicate using high-performance liquid chromatography (HPLC). Samples were also visually examined for macroscopic changes. The 0.3-mg/mL tacrolimus solution was also exposed to acidic treatment and heat to force its degr…
Tailoring the physicochemical properties of core-crosslinked polymeric micelles for pharmaceutical applications.
2016
To optimally exploit the potential of (tumor-) targeted nanomedicines, platform technologies are needed in which physicochemical and pharmaceutical properties can be tailored according to specific medical needs and applications. We here systematically customized the properties of core-crosslinked polymeric micelles (CCPM). The micelles were based on mPEG-b-pHPMAmLacn (i.e. methoxy poly(ethylene glycol)-b-poly[N-(2-hydroxypropyl) methacrylamide-lactate]), similar to the block copolymer composition employed in CriPec® docetaxel, which is currently in phase I clinical trials. The CCPM platform was tailored with regard to size (30 to 100 nm), nanocarrier degradation (1 month to 1 year) and drug…
Simulation-based design of a bipolar membranes electrodialysis unit for chemicals production from brines
2022
Nowadays environmental concerns are modifying the production and consumption patterns used so far. An important objective to improve our society is the use of sustainable processes that can reduce industrial waste streams. Bipolar membranes electrodialysis (EDBM) is an emerging environmentally friendly process that could be easily integrated into a circular economy approach to valorize waste brines. It is an electro-membrane process that allows the production of chemicals using only water, electrical energy and a salty solution. When electric current is applied to the electrodes of the EDBM stack, water dissociation takes place in the bipolar membranes. Therefore, the ions from water are co…
Appeal against the Decision on the Application for a Declaration on enforceability. Procedure to Contest the Decision Given on Appeal. Refusal or Rev…
2016
Lo scritto è un commento agli articoli da 50 a 58 del Regolamento n. 650 del 2012 del Parlamento Europeo e del Consiglio del 4 luglio 2012, relativo alla competenza, alla legge applicabile, al riconoscimento e all’esecuzione delle decisioni e all’accettazione e all’esecuzione degli atti pubblici in materia di successioni e alla creazione di un certificato successorio europeo. Lo scritto affronta i temi relativi alla impugnazione avverso la decisione emessa in seguito alla istanza per il riconoscimento delle sentenze e dei provvedimenti stranieri nelle materie oggetto del regolamento; il procedimento per impugnare le sentenza emesse in seguito all'appello; il rifiuto o la revoca del riconosc…
Justicia civil a debate: qué, por qué y cómo (Pasado, presente y retos de futuro del proceso civil)” (Debate On Civil Justice: What, Why and How (Pas…
2017
Spanish Abstract: La neo-modernidad, consecuencia de la globalizacion, nos presenta la crisis del modelo de Justicia civil tradicional. Una crisis que ha propiciado una metamorfosis de la Justicia: se reconoce el derecho al acceso a la Justicia, pero esta se presenta como un “Multi-rooms Justice System” en el que conviven los tribunales con las ADR/ODR; es una Justicia cada vez mas digital, mas agil, pero demasiado inspirada en el pensamiento economicista, que pone en peligro los valores esenciales de la dignidad y la igualdad de las personas. English Abstract: Neo-modernity, a consequence of globalization, presents the crisis of the model of traditional Civil Justice. A crisis that has led…
Compensating acquitted pre-trial detainees
2015
Abstract Western legal systems are far from having provided the same solution to the problem of whether acquitted pre-trial detainees should be compensated for the harm suffered as a result of detention on remand. Various arguments have been formulated in order to justify or criticize this compensation, but the possible incentive effects of this compensation on criminal behavior has not yet been considered. This paper analyzes these effects, focusing on the case where detention was lawfully and diligently carried out by State agents, and not having been caused by negligence on the part of the detainee. The paper shows that such compensation can either deter crime or encourage it, depending …