Search results for "CEF"
showing 10 items of 318 documents
Further development of the β-lactamase MutaGen assay and evaluation by comparison with Ames fluctuation tests and theumu test
2005
A rapid, high-throughput bacterial mutagenicity test system has been developed (MutaGen test) that detects reversions of inactivating base-pair substitutions and frameshifts in a TEM-1 class A β-lactamase (ampicillinase) gene. To quickly and sensitively detect mutagens, the system utilises a series of plasmids that contain the mutated ampicillinase gene and the mucAB operon. Inactivating mutations in the ampicillinase gene include frameshifts integrated into repetitive GC-sequences and G-runs known to be mutagenic hot-spots, and base-pair substitutions inserted in or around the β-lactamase active site. Frameshift mutations completely inactivated the enzyme only when located downstream of th…
Petrography and decay of a marly limestone in the cloister of a medieval cathedral in Sicily
2004
This paper deals with a significant process of decohesion of a marly limestone, taking place in the cloister of the medieval Cathedral of Cefalu, a pleasant town on the northern coast of Sicily. After desalination with deionised water and consolidation with ethyl silicate, the decay of the stone became faster. The aim of our study is to characterise the stony material and investigate the observed decay phenomena. The stone, that is a poor building material indeed, is characterised by means of petrographical, chemical and physical analyses on samples taken from the monument. Furthermore, experimental tests are performed in the laboratory in order to highlight the causes of incompatibility be…
Abordajes Terapéuticos No Farmacológicos para el Tratamiento de la Cefalea Tensional. Revisión bibliográfica.
2013
Introducción: La cefalea tensional (CT) es la más prevalente dentro de las cefaleas primarias. Representa un impacto económico alto y una repercusión importante en la vida de los pacientes que las sufren y en el sistema público de salud. Objetivos: Conocer el número y fechas de publicación de los estudios realizados en el tratamiento de la CT. Material y Métodos: Se procedió a una búsqueda bibliográfica en PubMed recurriendo al uso de las palabras clave contenidas en dichas publicaciones referidas específicamente a CT y se realizó una búsqueda incluyendo los términos tension-type headache y manual therapy, manipulation therapy, physical therapy, vertebral manipulation, cervical manipulation…
Eficacia De La Técnica De Thrust En Rotación Del Atlas Con Contacto Indexial En Pacientes Con Cefalea Tensional: Estudio Piloto
2013
Introducción: La cefalea tensional (CT) es uno de los dolores de cabeza más comunes en la población. Su prevalencia es alta y puede influir en la calidad de vida, el entorno laboral y social, induciendo a la ingesta de fármacos y favoreciedo la cefalea crónica. Objetivos: Evaluar la eficacia de la técnica de thrust en rotación del atlas, con contacto indexial, (TTRA) en pacientes con CT. Material y Métodos: Se realizó un estudio piloto aleatorizado. La muestra estuvo formada por veintinueve pacientes (n=29), los cuales fueron aleatoriamente distribuidos en dos grupos; experimental (GE, n=12) y control (GC, n=17). Ambos grupos fueron evaluados con mediciones goniométricas antes y después de …
Factors affecting flavor perception in space: Does the spacecraft environment influence food intake by astronauts?
2020
International audience; The intention to send a crewed mission to Mars involves a huge amount of planning to ensure a safe and successful mission. Providing adequate amounts of food for the crew is a major task, but 20 years of feeding astronauts on the International Space Station (ISS) have resulted in a good knowledge base. A crucial observation from the ISS is that astronauts typically consume only 80% of their daily calorie requirements when in space. This is despite daily exercise regimes that keep energy usage at very similar levels to those found on Earth. This calorie deficit seems to have little effect on astronauts who spend up to 12 months on the ISS, but given that a mission to …
In silico identification and experimental validation of hits active against KPC-2 β-lactamase
2018
Bacterial resistance has become a worldwide concern, particularly after the emergence of resistant strains overproducing carbapenemases. Among these, the KPC-2 carbapenemase represents a significant clinical challenge, being characterized by a broad substrate spectrum that includes aminothiazoleoxime and cephalosporins such as cefotaxime. Moreover, strains harboring KPC-type β-lactamases are often reported as resistant to available β-lactamase inhibitors (clavulanic acid, tazobactam and sulbactam). Therefore, the identification of novel non β-lactam KPC-2 inhibitors is strongly necessary to maintain treatment options. This study explored novel, non-covalent inhibitors active against KPC-2, …
Solar and interplanetary triggers of the largest Dst variations of the solar cycle 23
2012
Abstract We present the results of an investigation from the Sun to the Earth of the sequence of events that caused major Dst decreases (Δ Dst ≤ – 100 nT during 1 h) that occurred during 1996–2005. These events are expected to be better related to geomagnetic induced current (GIC) events than those events where any geomagnetic index is far from its quiet time value. At least one full halo CME with a speed on the plane of sky above 900 km/s participates in every studied event. The seven events were triggered by interplanetary signatures, which arise as a consequence of interaction among different solar ejections. The interaction arises at different stages from the solar surface, between segm…
Two-dimensional numerical modeling of fracturing and shear band development in glacier fronts
2014
In this contribution we present a two-dimensional numerical model of a deforming glacier front. The model is based on a hybrid lattice spring network approach where particles in the model can deform in a volume conservative visco-elastic manner but at the same time they can be compressed elastically and fracture by discrete failure. We restrict ourselves to a simple setting where the glacier sits on a frictionless slope that dips with 5–10°, the ice block is fixed on one side and has a free surface on the other. The glacier varies in viscosity and can flow at the base, whereas it is brittle at the top. Results show that the head of the glacier is unstable. Failure happens as a combination o…
La committenza di Francesco Gonzaga vescovo della diocesi di Cefalù (1587-1593)
2022
Francesco Gonzaga, al secolo Annibale (1546-1620), giunse in Sicilia «già carico di prestigio» (Brunelli). Nipote del cardinale Ercole e di don Ferrante (suoi precettori) e fratello del cardinale Scipione fu educato alla corte di Mantova e alla corte di Filippo II in Fiandra e in Spagna (insieme ad Alessandro Farnese). Dopo avere ricoperto il ruolo di ministro generale dei Francescani Osservanti, nel 1587 fu eletto, su nomina regia, vescovo di Cefalù. Zelante e rigoroso “riformatore”, estimatore di Carlo Borromeo e in rapporti con quest’ultimo, avviò un’intensa attività di riforma della diocesi. Tra le iniziative promosse e indagate a partire dalle fonti, dalla documentazione e da quanto in…