Search results for "CELLULAR"

showing 10 items of 6449 documents

Docosahexaenoic acid and other fatty acids induce a decrease in pHiin Jurkat T-cells

2003

Docosahexaenoic acid (DHA) induced rapid (t1/2=33 s) and dose-dependent decreases in pHi in BCECF-loaded human (Jurkat) T-cells. Addition of 5-(N,N-dimethyl)-amiloride, an inhibitor of Na+/H+ exchanger, prolonged DHA-induced acidification as a function of time, indicating that the exchanger is implicated in pHi recovery. Other fatty acids like oleic acid, arachidonic acid, eicosapentaenoic acid, but not palmitic acid, also induced a fall in pHi in these cells. To assess the role of calcium in the DHA-induced acidification, we conducted experiments in Ca2+-free (0% Ca2+) and Ca2+-containing (100% Ca2+) buffer. We observed that there was no difference in the degree of DHA-induced transient ac…

Pharmacologychemistry.chemical_classificationmedicine.medical_specialtyIntracellular pHfood and beveragesFatty acidEicosapentaenoic acidchemistry.chemical_compoundEndocrinologychemistryBiochemistryBAPTADocosahexaenoic acidInternal medicinemedicinelipids (amino acids peptides and proteins)Arachidonic acidUnsaturated fatty acidPolyunsaturated fatty acidBritish Journal of Pharmacology
researchProduct

Effect of two phenanthrene alkaloids on angiotensin II-induced leukocyte-endothelial cell interactionsin vivo

2003

The present study has evaluated the effect of two phenanthrene alkaloids, uvariopsine and stephenanthrine, on angiotensin II (Ang-II)-induced leukocyte–endothelial cell interactions in vivo and the mechanisms involved in their activity. Intravital microscopy within the rat mesenteric microcirculation was used. A 60 min superfusion with 1 nM Ang-II induced a significant increase in the leukocyte–endothelial cell interactions that were completely inhibited by 1 μM uvariopsine cosuperfusion. A lower dose of 0.1 μM significantly reduced Ang-II-induced leukocyte adhesion by 75%. When Ang-II was cosuperfused with 1 and 0.1 μM stephenanthrine, Ang-II-induced leukocyte responses were significantly …

Pharmacologychemistry.chemical_classificationmedicine.medical_specialtyReactive oxygen speciesPlatelet-activating factorSuperoxideLeukocyte RollingPharmacologyN-Formylmethionine leucyl-phenylalanineAngiotensin IIEndothelial stem cellchemistry.chemical_compoundEndocrinologychemistryInternal medicinemedicineIntracellularBritish Journal of Pharmacology
researchProduct

Fine structure of sensilla during moulting inNeomysis integer (Leach) (Crustacea, Mysidacea)

1980

During the moulting cycle the sensory cells and the newly formed hair shaft remain connected to the old cuticular receptive apparatus of the sensillum by the elongated outer segments of the dendrites, which run through the exuvial space. A surface coat covering the outer dendritic segments protects them against the chemical influences of the exuvial fluid. The findings suggest that the receptors remain functional until ecdysis. This moulting type is considered to be a transitional form between the moulting types so far known.

Pharmacologyintegumentary systemHair shaftMysidaceaCell BiologyAnatomyBiologybiology.organism_classificationSensory cellCrustaceanCell biologyCellular and Molecular NeuroscienceEcdysisMolecular MedicineMolecular BiologyMoultingSensillumExperientia
researchProduct

The control of amygdaloid and temporal paroxysmal activity by the caudate nucleus

1971

In gatti curarizzati ed in gatti portatori di elettrodi a dimora e liberi di muoversi, la stimolazione ripetitiva ad alta frequenza del nucleo caudato inibisce la comparsa sia dei fenomeni bioelettrici parossistici focalizzati nell'amigdala e nella corteccia temporale sia dei fenomeni comportamentali omologabili all'epilessia psicomotoria.

Pharmacologymedicine.medical_specialtyCaudate nucleusCell BiologyBiologyAmygdalaElectric StimulationTemporal LobeCellular and Molecular NeuroscienceEndocrinologyEpilepsy Temporal LobeSeizuresAnesthesiaInternal medicineCatsmedicineAnimalsMolecular MedicineCaudate NucleusMolecular BiologyExperientia
researchProduct

Zum Einfluss von Angiotensin II auf die Nebennierenrinde unter chemischer adrenostase mit SU 4885 (Metopiron)

1964

The inhibition of 11-β-hydroxylase in the adrenal cortex with SU 4885 (metopiron) increases the ACTH-secretion. Val5-angiotensin II blocks the reaction of the anterior pituitary gland similarly as does dexamethasone. Mode and intensity of this action of angiotensin II, and the influence on rats treated as described, are studied.

Pharmacologymedicine.medical_specialtyChemistryAdrenal cortexCell BiologyAngiotensin IICellular and Molecular Neurosciencemedicine.anatomical_structureEndocrinologyAnterior pituitaryInternal medicinemedicineMolecular MedicineMolecular BiologyDexamethasonemedicine.drugExperientia
researchProduct

Der Einfluss von Acetylcholin auf die42Kalium-Abgabe postnataler, denervierter und reinnervierter Skeletmuskulatur

1960

The loss of42K from the isolated rat diaphragm into the bathing solution is increased by acetylcholine, (a) 3 to 4 days after birth, (b) 7 to 14 days after sectioning of the phrenic nerve. The42K loss is not altered by acetylcholine in the diaphragm of adult rats and after the denervated diaphragm has become reinnervated.

Pharmacologymedicine.medical_specialtyChemistryCell BiologyAnatomymusculoskeletal systemDiaphragm (structural system)Cellular and Molecular NeuroscienceEndocrinologyInternal medicinemedicineMolecular MedicineRat DiaphragmMolecular BiologyAcetylcholinemedicine.drugPhrenic nerveExperientia
researchProduct

Erythrocytäre Anionenkonzentrationen bei renaler Insuffizienz

1966

In chronic renal insufficiency, concentrations of chloride and inorganic phosphate in human red blood cells are elevated. There is no correlation between serum non-protein nitrogen and the anionic concentrations of red blood cells. Positive correlations exist between corresponding cellular and extracellular anionic concentrations.

Pharmacologymedicine.medical_specialtyChemistryCell BiologyChlorideCellular and Molecular NeuroscienceEndocrinologyInorganic phosphateBiochemistryInternal medicinemedicineExtracellularMolecular MedicineChronic renal insufficiencyMolecular Biologymedicine.drugExperientia
researchProduct

Moulting hormone content in prothoracic glands and oenocytes ofTenebrio molitor within a moulting cycle

1973

An isolierten und homogenisierten Prothorakaldrusen und Oenocyten vonTenebrio wurde der Gehalt an Hautungshormonen mit Hilfe des Calliphoratests bestimmt. Dabei stellte sich heraus, dass sowohl Prothorakaldrusen als auch Oenocyten wahrend des gesamten Hautungszyklus verpuppungsaktive Stoffe, wenn auch in unterschiedlicher Menge, enthalten. Die Ergebnisse werden mit jenen verglichen, bei denen der Hormontiter durch Extraktion ganzer Tiere bestimmt wurde. In Verbindung damit wurde das Zusammenspiel von Synthese und Abbau der Hormone diskutiert.

Pharmacologymedicine.medical_specialtyChemistryCell BiologyProthoracic glandMolecular biologyCellular and Molecular NeuroscienceEndocrinologyInternal medicinemedicineMolecular MedicineMolecular BiologyMoultingHormoneExperientia
researchProduct

Die Hemmbarkeit der inhibitorischen Adrenalinbzw. Noradrenalinwirkung durch Adrenolytika

1958

Dibenamine, dihydroergotamine, regitin and priscol were found to antagonize specifically the inhibitory action of adrenaline and noradrenaline on the electrically stimulated isolated ileum of the guinea-pig. The antagonistic action of dibenamine was irreversible.

Pharmacologymedicine.medical_specialtyChemistryIleumCell BiologyInhibitory postsynaptic potentialDihydroergotamineCellular and Molecular NeuroscienceEndocrinologymedicine.anatomical_structureEpinephrineInternal medicinemedicineAdrenergic antagonistMolecular MedicineSympatholyticsMolecular Biologymedicine.drugExperientia
researchProduct

Zur Wirkung von Oxytocin auf einen autorhythmischen glatten Gefässmuskel

1972

The influence of oxytocine on the spontaneously contractile portal vein of the rat has been investigated. This octapeptide decreases the active tension and abolished it completely at a concentration of 5×10−7g/ml. The effect is not caused by an adrenergic mechanism but by a direct action on the smooth muscle cell.

Pharmacologymedicine.medical_specialtyChemistryPortal veinAdrenergicCell BiologyCellular and Molecular NeuroscienceEndocrinologySmooth muscleOxytocinInternal medicinemedicineMolecular MedicineActive tensionmedicine.symptomMolecular BiologyMuscle contractionmedicine.drugExperientia
researchProduct