Search results for "CELLULAR"
showing 10 items of 6449 documents
Subcellular distribution of calpain-1 and calpain-2 as a key event for calpain-mediated functions in physiological and neoplastic mammary models
2019
Calpains are a family of calcium-dependent proteases, which modulate their substrates rather than degrade them in such a way that modifies them. Calpains deregulations have been determined as an aggravating factor of different diseases, including cancer. Nevertheless, there are no clear records about the particular contribution of each calpain isoform in physiological processes and how these isoforms are deregulated in pathological conditions. In vivo, each calpain isoform recognizes specific proteins as substrates, and it has been suggested that calpains subcellular localization might determine their substrate recognition, and consequently their functions. In the present study we have expl…
Development of biosensors for detection of alpha-fetoprotein: As a major biomarker for hepatocellular carcinoma
2020
Abstract Alpha-fetoprotein as a multifunctional glycoprotein with a dual regulatory role in cancer and fetal activities is belonging to an albuminoid gene family. Due to important biological activities of alpha-fetoprotein in the adjustment of cancer, the level of this biomarker, majorly in liver carcinomas, abnormally is elevated. Also, the probability of high-risk or low-risk patients for chromosomal abnormalities can be identified by the serum level of alpha-fetoprotein. The detection of biomarkers possesses an important role in prognosis and early diagnosis of cancer and other diseases. So, the development of accurate and sensitive methods for measurement of alpha-fetoprotein is of grea…
Technologies for green radio communication networks
2011
Since the introduction of cellular communications in the early '80s, the demand for two-way mobile communication services has increased tremendously. Today there are over 4 billion mobile users and 4.6 million radio base station sites worldwide. This rapid growth of the cellular mobile industry has been at the price of increased energy consumption and a sizable carbon footprint.
A simulation study of load balancing algorithms in cellular packet networks
2001
This paper provides a comparative performance evaluation of various load balancing schemes in cellular packet networks. With respect to traditional schemes, that measure each cell load in terms of number of admitted calls, our schemes use supplementary packet level information, expressed in terms of effective resource consumption of each individual call when retransmission mechanisms are employed. The simulation model adopted is based on a toroidal cellular network topology, to avoid border effects affecting the numerical results.
Mobile Electronic Commerce: Emerging Issues
2000
There are many definitions for Mobile Electronic Commerce (M-Commerce). We define M-Commerce as any type of transaction of an economic value having at least at one end a mobile terminal and thus using the mobile telecommunications network. The Wireless Application Protocol (WAP) plays an important role in m-commerce by optimizing Internet standards for the constraints of the wireless environment and thus bridging the gap between Internet and mobile world. Mobile Network Operators can play a major role in m-commerce by being strategically positioned between customers and content/service providers. In this paper we investigate the roles the operator can play in m-commerce and discuss respecti…
A Controlled Trial of Two Acellular Vaccines and One Whole-Cell Vaccine against Pertussis
1996
Background Concern about both safety and efficacy has made the use of whole-cell pertussis vaccines controversial. In some European countries, including Italy, the rate of vaccination against pertussis is low. Methods We conducted a double-blind trial in Italy in which infants were randomly assigned to vaccination at two, four, and six months of age with an acellular pertussis vaccine together with diphtheria and tetanus toxoids (DTP); a DTP vaccine containing whole-cell pertussis (manufactured by Connaught Laboratories); or diphtheria and tetanus toxoids without pertussis (DT). The acellular DTP vaccine was either one containing filamentous hemagglutinin, pertactin, and pertussis toxin ina…
Tear <sup>1</sup>H Nuclear Magnetic Resonance-Based Metabolomics Application to the Molecular Diagnosis of Aqueous Tear Deficiency and Me…
2020
<b><i>Purpose:</i></b> Meibomian gland dysfunction (MGD) is a major cause of signs and symptoms related to dry eyes (DE) and eyelid inflammation. We investigated the composition of human tears by metabolomic approaches in patients with aqueous tear deficiency and MGD. <b><i>Methods:</i></b> Participants in this prospective, case-control pilot study were split into patients with aqueous tear deficiency and MGD (DE-MGD [<i>n</i> = 15]) and healthy controls (CG; <i>n</i> = 20). Personal interviews, ocular surface disease index (OSDI), and ophthalmic examinations were performed. Reflex tears collected by capillarity were pr…
New glucocorticoids. Mechanisms of immunological activity at the cellular level and in the clinical setting.
1990
Targeting tumor-initiating cells and compensatory YAP pathway to overcome sorafenib resistance in hepatocellular carcinoma
2021
Neuron-Glial Interaction During Injury and Edema of the CNS
1994
During injury and ischemia of the CNS mediator compounds are released or activated which cause secondary swelling and damage of nerve cells. Such mediators are glutamate, acidosis, free fatty acids, or high extracellular potassium. Glial homeostatic mechanisms are activated to prevent the secondary injury from these mediators. The glial clearance mechanisms have been studied in detail using in vitro systems allowing for a close control of the glial environment. Current evidence suggests glial swelling to occur together with glutamate uptake or in response to extracellular acidosis. Glial swelling, therefore, is rather the result of homeostatic mechanisms than an indication of glial demise.