Search results for "CELLULAR"

Orienting of visuo-spatial attention in developmental dyslexia

2008

Innovative and Applied Research in Biology: Proceedings, Vol. 2

2020

The collection contains SCIENTIFIC articles on the topics of the LU 78 conference reports. The main focus is on innovative and applied research in biology and interdisciplinary fields.

Exploration of extracellular vesicles from

2018

ABSTRACT The prevalent porcine helminth, Ascaris suum, compromises pig health and reduces farm productivity worldwide. The closely related human parasite, A. lumbricoides, infects more than 800 million people representing a disease burden of 1.31 million disability-adjusted life years. The infections are often chronic in nature, and the parasites have a profound ability to modulate their hosts’ immune responses. This study provides the first in-depth characterisation of extracellular vesicles (EVs) from different developmental stages and body parts of A. suum and proposes the role of these vesicles in the host–parasite interplay. The release of EVs from the third- (L3) and fourth-stage (L4)…

Vortex dynamics in rotating counterflow and plane Couette and Poiseuille turbulence in superfluid Helium

2008

An equation previously proposed to describe the evolution of vortex line density in rotating counterflow turbulent tangles in superfluid helium is generalized to incorporate nonvanishing barycentric velocity and velocity gradients. Our generalization is compared with an analogous approach proposed by Lipniacki, and with experimental results by Swanson et al. in rotating counterflow, and it is used to evaluate the vortex density in plane Couette and Poiseuille flows of superfluid helium.

Water Dynamics in Biological Systems investigated using Neutron Scattering Techniques

Living systems can not survive in absence of the water environments which play a fundamental role in living functions. Thus in the scienti?c community many studies were and are addressed to characterize water and its dynamics properties in biological systems. However, a clear description of water in such systems has been not reached yet. In fact, the investigations performed with di?erent techniques - those based on Nuclear Magnetic Resonance or those based on Neutron Scattering - look at di?erent di?usive motions and interactions water-biomolecules, leading controversial results and hence generating many debates between scientists. In this thesis we support the idea that two water populati…

Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity

2011

Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…

Incidence de la clarification des moûts de raisin sur les fermentescibilltés alcoolique et malolactique

1993

<p style="text-align: justify;">Des essais de débourbage en vinification en blanc, réalisés de 1988 à 1992, mettent en évidence le rôle important joué par la teneur en macromolécules solubles dans le moût de raisin. Les moûts de faible turbidité conduisent en effet à des fermentations alcooliques lentes en relation avec de faibles populations levuriennes. Il est également confirmé que la libération de polysaccharides exocellulaires par les levures au cours de la fermentation alcoolique est d'autant plus élevée que le moût de départ a été fortement appauvri en colloïdes de raisin. Par contre, ce sont dans les lots les plus clarifiés que l'on observe la meilleure fermentescibilité malol…

Analysis of MAC-level throughput in LTE systems with link rate adaptation and HARQ protocols

2015

LTE is rapidly gaining momentum for building future 4G cellular systems, and real operational networks are under deployment worldwide. To achieve high throughput performance, in addition to an advanced physical layer design LTE exploits a combination of sophisticated mechanisms at the radio resource management layer. Clearly, this makes difficult to develop analytical tools to accurately assess and optimise the user perceived throughput under realistic channel assumptions. Thus, most existing studies focus only on link-layer throughput or consider individual mechanisms in isolation. The main contribution of this paper is a unified modelling framework of the MAC-level downlink throughput of …

Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat diet fed mice.

2018

Accumulating evidence indicates that gut microbiota plays a significant role in obesity, insulin resistance and associated liver disorders. Family Enterobacteriaceae and especially Enterobacter cloacae strain B29 have been previously linked to obesity and hepatic damage. The underlying mechanisms, however, remain unclear. Therefore, we comprehensively examined the effects of E. cloacae subsp. cloacae (ATCC® 13047™) administration on host metabolism of mice fed with high-fat diet (HFD). C57BL/6N mice were randomly divided into HFD control, chow control, and E. cloacae treatment groups. The E. cloacae treatment group received live bacterial cells in PBS intragastrically twice a week, every ot…

Low levels of both xanthine dehydrogenase and of cellular retinol binding protein are responsible for retinoic acid deficiency in malignant human mam…

2009

The seeming impairment of retinoid metabolism in human breast tumor cells has been attributed to the lower expression of cellular retinol binding proteins (CRBPs), of alcohol/retinol dehydrogenases, or aldehyde/retinaldehyde dehydrogenases. In a previous study we indicated that xanthine dehydrogenase (XDH) is able to oxidize actively both all-trans-retinol (t-ROL) bound to the CRBP (holo-CRBP) and all-trans-retinaldehyde (t-RAL) to all-trans-retinoic acid (t-RA) in human mammary epithelial cells (HMEC). Since both XDH and CRBP are required for the biosynthesis of t-RA, we have inspected their bioavailability in both estrogen-responsive and nonresponsive human mammary epithelial cancer cells…