Search results for "CEM"
showing 10 items of 3487 documents
An animated agent as a child's partner in practicing of cognitive skills in a computer-mediated environment
2000
Asymmetrical muscle strength deficit, mobility limitation and aquatic resistance training in persons with knee osteoarthritis
2013
Measurement of dielectron production in central Pb-Pb collisions at √sNN = 2.76 TeV
2019
Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. The first measurement of dielectron (e + e −) production in central (0 – 10 %) Pb – Pb collisions at √sNN=2.76TeV at the LHC is presented. The dielectron invariant-mass spectrum is compared to the expected contributions from hadron decays in the invariant-mass range 0 < mee < 3.5 GeV / c2. The ratio of data and the cocktail of hadronic contributions without vacuum ρ0 is measured in the invariant-mass range 0.15 < mee < 0.7 GeV / c2, w…
The Nasal Epithelium as a Factory for Systemic Protein Delivery
2002
We have previously shown that recombinant Sendai virus (SeV) produces efficient in vivo airway epithelial gene transfer. The ability to produce therapeutic levels of circulating proteins following noninvasive gene transfer would have widespread clinical application. Here, we compared nose, lung, and skeletal muscle for the ability to produce circulating levels of the secreted mouse antiinflammatory cytokine interleukin-10 (IL10) following SeV-mediated gene transfer. High levels of serum IL10 were obtained from each site with a potency order of lung > nose > muscle for a given viral titer. Serum levels from each site were within the likely required range for anti-inflammatory effects. The co…
Genomic structure and promoter analysis of pathogen-inducedrepatgenes fromSpodoptera exigua
2009
The repat gene family encodes midgut proteins overexpressed in response to pathogen infection in the lepidopteran Spodoptera exigua. Up-regulation of repat genes has been observed after challenging the larvae with both Bacillus thuringiensis toxins and after infection with the baculovirus Autographa californica multiple nucleopolyhedrovirus. In our study, PCR amplification of the genomic region and genome walking were used to obtain the genomic structure and the sequence of the 5'-upstream region of repat1 and repat2, two of the most phylogenetically distant members of the repat family. A similar gene structure between repat1 and repat2 has been found, with conserved exon-intron positions a…
PTC124-mediated translational readthrough of a nonsense mutation causing Usher syndrome type 1C.
2011
We investigated the therapeutic potential of the premature termination codon (PTC) readthrough-inducing drug PTC124 in treating the retinal phenotype of Usher syndrome, caused by a nonsense mutation in the USH1C gene. Applications in cell culture, organotypic retina cultures, and mice in vivo revealed significant readthrough and the recovery of protein function. In comparison with other readthrough drugs, namely the clinically approved readthrough-inducing aminoglycoside gentamicin, PTC124 exhibits significant better retinal biocompatibility. Its high readthrough efficiency in combination with excellent biocompatibility makes PTC124 a promising therapeutic agent for PTCs in USH1C, as well a…
X-ray tomographic method for measuring three-dimensional deformation and water content distribution in swelling clays
2015
A non-invasive method for simultaneous measurement of the 3D displacement field and the water content distribution of a wetted solid material is developed. The method is based on comparison of X-ray tomographic images of a material sample in the reference state and in the wetted and deformed state. The deformation and water content analyses were successfully compared with numerical results for a cylindrical rubber test sample under axial compression, and with gravimetric results from axially wetted and sliced cylindrical bentonite samples, respectively. The methods were applied in a 4D study (three spatial dimensions and time) of wetting and deformation of purified swelling bentonite doped …
Układ częściowy obejmujący wierzytelności zabezpieczone rzeczowo a zawieszenie egzekucji z mocy prawa
2018
Niniejsze opracowanie odnosi się do problematyki wpływu otwarcia przyspieszonego postępowania układowego z układem częściowym na postępowanie egzekucyjne dotyczące wierzytelności zabezpieczonej rzeczowo na składnikach majątku dłużnika. Zaprezentowany zostanie pogląd prawny, i jego uzasadnienie, według którego, w przypadku gdy wierzytelność zabezpieczona rzeczowo na majątku dłużnika zostaje objęta układem częściowym wówczas egzekucja co do niej ulega bezwzględnemu zawieszeniu z mocy samego prawa (ipso iure)
Trajectory Design and Resource Allocation for Multi-UAV Networks : Deep Reinforcement Learning Approaches
2023
The future mobile communication system is expected to provide ubiquitous connectivity and unprecedented services over billions of devices. The unmanned aerial vehicle (UAV), which is prominent in its flexibility and low cost, emerges as a significant network entity to realize such ambitious targets. In this work, novel machine learning-based trajectory design and resource allocation schemes are presented for a multi-UAV communications system. In the considered system, the UAVs act as aerial Base Stations (BSs) and provide ubiquitous coverage. In particular, with the objective to maximize the system utility over all served users, a joint user association, power allocation and trajectory desi…
Numerical analysis of the mechanical response of wood glulam beams reinforced through the thickness by FRP rods
2009
The modern use of through-thickness reinforcement in wood glulam (glued laminated) beams, bridging the potential delamination crack faces, has shown to be an effective technological solution to improve their interlaminar fracture strength. In this paper, the behaviour of wood glulam beams is investigated from an experimental and numerical point of view, comparing the mechanical response of unreinforced and reinforced (by FRP rods) beams subjected to four points bending tests. For the numerical analysis, a simple two-phases (joint and reinforcement) interface model has been formulated and implemented in a finite element code. In particular, the classical interface model for adhesive joint, a…