Search results for "CF"

7C: Computational Chromosome Conformation Capture by Correlation of ChIP-seq at CTCF motifs.

2019

Abstract Background Knowledge of the three-dimensional structure of the genome is necessary to understand how gene expression is regulated. Recent experimental techniques such as Hi-C or ChIA-PET measure long-range chromatin interactions genome-wide but are experimentally elaborate, have limited resolution and such data is only available for a limited number of cell types and tissues. Results While ChIP-seq was not designed to detect chromatin interactions, the formaldehyde treatment in the ChIP-seq protocol cross-links proteins with each other and with DNA. Consequently, also regions that are not directly bound by the targeted TF but interact with the binding site via chromatin looping are…

A Synthetic MUC1 Anticancer Vaccine Containing Mannose Ligands for Targeting Macrophages and Dendritic Cells

2017

A MUC1 anticancer vaccine equipped with covalently linked divalent mannose ligands was found to improve the antigen uptake and presentation by targeting mannose-receptor-positive macrophages and dendritic cells. It induced much stronger specific IgG immune responses in mice than the non-mannosylated reference vaccine. Mannose coupling also led to increased numbers of macrophages, dendritic cells, and CD4+ T cells in the local lymph organs. Comparison of di- and tetravalent mannose ligands revealed an increased binding of the tetravalent version, suggesting that higher valency improves binding to the mannose receptor. The mannose-coupled vaccine and the non-mannosylated reference vaccine ind…

Validation of Teacher Self-efficacy (QAI) Questionnaire

2021

Negli ultimi anni numerose ricerche nazionali e internazionali hanno messo in evidenza l’importanza della Teacher Self Efficacy. Nonostante nel panorama nazionale esistano già alcuni strumenti che indagano tale costrutto, si notano sovrapposizioni e divergenze nei diversi fattori presi in considerazione, quali ad esempio la percezione di autoefficacia relativa alla possibilità di agire sull’engagement degli studenti e sulla colla- borazione con la famiglia e altre figure professionali. Pertanto l’obiettivo del presente contributo consiste nella costruzione e validazione di un nuovo strumento che tenga conto di entrambi quest’ultimi aspetti. Lo strumento, costituito da 25 item, è stato so…

Computational Modeling of Ascending Thoracic Aortic Aneurysm and Dissection

CFD prediction of bubbles local gas hold-up in 2-dimensional gas-solid fluidized beds

2008

Tirdzniecības stratēģija un tās pielietošana CFD valūtas tirdzniecībā

2021

Darba autora iepriekšējā pieredze, nodarbojoties ar CFD instrumentiem, rāda, ka reālas iespējas nopelnīt ir, lai gan jāuzsver, ka peļņa pārsvarā ir gūta īstermiņā, ilgtermiņā, tomēr, rezultāti ir bijuši negatīvi. Galvenais trūkums kurš ir konstatēts, ir tas, ka trūkst stratēģiski pārdomātas rīcības tirdzniecības darījumos, kurš balstītos uz konkrētām darbībām, spētu dot sagaidāmus rezultātus no tirdzniecības ilgtermiņā. Negatīvā pieredze lika autoram aizdomāties par stratēģijas nozīmīgumu tirdzniecības darījumu veikšanā un nepieciešamību pētīt tirdzniecības stratēģiju izveides principus. Darba mērķis: pamatojoties uz teorētiskām atziņām par tirdzniecības stratēģijas izveidi izstrādāt un apr…

Study of the performances of a fluidynamic actuator

2018

Aim of this paper is presented a new methodology to study how different geometric parameters affect the performance of a hydraulic actuator. Preliminarily, the real working conditions of a hydraulic machine have been simulated by means of a CFD module. After, to test the reliability of the simulations, the obtained numerical results have been compared with the experimental data of a real prototype. This comparison demonstrates a good level of agreement between numerical and experimental results. Different simulations have been setup by modifying the actuator geometry and evaluating the efficiency of every analysed configuration. The results of this study give useful guidelines for the choic…

CFD simulation of solid-liquid suspension startup in a stirred tank

2008

Top-covered unbaffled stirred tanks: experiments and numerical simulations

2015

In this work computational fluid dynamics was employed to predict the flow field of an unbaffled stirred tank from steady to turbulent conditions

On the Simulation of Solid Particle Distribution in Multiple Impeller Agitated Tanks via Computational Fluid Dynamics

1998