Search results for "CGA"
showing 10 items of 35 documents
Signalling strength determines proapoptotic functions of STING
2017
Mammalian cells use cytosolic nucleic acid receptors to detect pathogens and other stress signals. In innate immune cells the presence of cytosolic DNA is sensed by the cGAS–STING signalling pathway, which initiates a gene expression programme linked to cellular activation and cytokine production. Whether the outcome of the STING response varies between distinct cell types remains largely unknown. Here we show that T cells exhibit an intensified STING response, which leads to the expression of a distinct set of genes and results in the induction of apoptosis. Of note, this proapoptotic STING response is still functional in cancerous T cells and delivery of small molecule STING agonists prev…
Somatic copy number alterations are associated with EGFR amplification and shortened survival in patients with primary glioblastoma.
2019
Glioblastoma (GBM) is the most common malignant primary tumor of the central nervous system. With no effective therapy, the prognosis for patients is terrible poor. It is highly heterogeneous and EGFR amplification is its most frequent molecular alteration. In this light, we aimed to examine the genetic heterogeneity of GBM and to correlate it with the clinical characteristics of the patients. For that purpose, we analyzed the status of EGFR and the somatic copy number alterations (CNAs) of a set of tumor suppressor genes and oncogenes. Thus, we found GBMs with high level of EGFR amplification, low level and with no EGFR amplification. Highly amplified tumors showed histological features of…
Potestà regolamentare ed attuazione della legge sul procedimento amministrativo ed il diritto di accesso ai documenti amministrativi (l.r. n. 10 del …
1993
l'articolo mette in evidenza come il CGA per la Regione siciliana con due pareri importanti ha effettuato una vera e propria inversione di rotta in tema di esercizio della potestà regolamentare nell'ordinamento regionale siciliano
Logopēda un ģimenes sadarbība skaņu izrunas traucējumu mazināšanā piecgadīgiem bērniem
2015
Darba autore: Gunita Apšukrapša Darba tēma: LOGOPĒDA UN ĢIMENES SADARBĪBA SKAŅU IZRUNAS TRAUCĒJUMU MAZINĀŠANĀ PIECGADĪGIEM BĒRNIEM. Darba veids: Diplomdarbs. Studiju programma: Skolotājs – logopēds 204 CH. Darba zinātniskais vadītājs: Mg. paed. E. Laganovska. Darba apjoms: 38 lpp, ievads, 4 nodaļas, 1 nodaļa ar apakšnodaļām, empīriskā daļa, nobeigums, anotācija, literatūras saraksts, pielikumi. Atslēgas vārdi: logopēds, ģimene, sadarbība, piecgadnieks. Pētījuma mērķis: teorētiski un praktiski noskaidrot logopēda un ģimenes sadarbības iespējas skaņu izrunas traucējumu mazināšanā piecgadīgiem bērniem pirmskolās. Darba saturs: 1. piecgadnieka vecumposma raksturojums; 2. skaņu izrunas traucējum…
On the use of Denoising Autoencoders and Deep Convolutional Adversarial Networks for Automated Removal of Date Stamps
2019
Master's thesis Information- and communication technology IKT590 - University of Agder 2019 This thesis investigates to what extent the deep learning models such as DenoisingAutoencoder (DAE) and Deep Convolution General Adversarial Net (DCGAN)automate the removal of the date stamps from images with high resolution whilepreserving the rest of the images. Both DAE and DCGAN algorithms are im-plemented with Convolutional Neural Networks (CNN). The DAE algorithm canperform this task with entirely satisfactory results. The DAE can reconstruct theoriginal images from corrupted inputs with date stamps. While DCGAN deliverspoor yet interesting results. The images generated by the DCGAN are quite d…
Sociālo prasmju pilnveide piecgadīgiem bērniem ar autismu pirmsskolā
2022
Kvalifikācijas darba tēma ir “Sociālo prasmju pilnveide piecgadīgiem bērniem ar autismu pirmsskolā”. Darba mērķis ir noskaidrot paņēmienus, ar kuru palīdzību var pilnveidot sociālās prasmes 5 gadus veciem bērniem ar autismu pirmsskolā. Darbā izmantoti literatūras un elektroniskie informācijas avoti. Tika analizēts 5 gadus vecu bērnu attīstības raksturojums, sociālo prasmju pilnveides nepieciešamība, metodes sociālo prasmju pilnveidei pirmsskolā bērniem ar autismu, teorētiķu ieteikumi sociālo prasmju pilnveidē bērniem ar autismu. Darba teorētiskajā daļā ir veikta literatūras, 5 gadus vecu bērnu attīstības raksturojums, raksturota sociālo prasmju pilnveides nepieciešamība bērniem ar autismu, …
Tissue fluidification promotes a cGAS-STING cytosolic DNA response in invasive breast cancer.
2022
: The process in which locally confined epithelial malignancies progressively evolve into invasive cancers is often promoted by unjamming, a phase transition from a solid-like to a liquid-like state, which occurs in various tissues. Whether this tissue-level mechanical transition impacts phenotypes during carcinoma progression remains unclear. Here we report that the large fluctuations in cell density that accompany unjamming result in repeated mechanical deformations of cells and nuclei. This triggers a cellular mechano-protective mechanism involving an increase in nuclear size and rigidity, heterochromatin redistribution and remodelling of the perinuclear actin architecture into actin rin…
Design of the CGAL 3D Spherical Kernel and application to arrangements of circles on a sphere
2009
AbstractThis paper presents a cgal kernel for algorithms manipulating 3D spheres, circles, and circular arcs. The paper makes three contributions. First, the mathematics underlying two non-trivial predicates are presented. Second, the design of the kernel concept is developed, and the connexion between the mathematics and this design is established. In particular, we show how two different frameworks can be combined: one for the general setting, and one dedicated to the case where all the objects handled lie on a reference sphere. Finally, an assessment about the efficacy of the 3D Spherical Kernel is made through the calculation of the exact arrangement of circles on a sphere. On average w…
Digitālais pirkuma objekts: monogrāfija
2022
Pan-cancer analysis of whole genomes
2020
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