Search results for "CHEMICAL CHARACTERIZATION"

Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatme…

2016

NSC12 is an orally available pan-FGF trap able to inhibit FGF2/FGFR interaction and endowed with promising antitumor activity. It was identified by virtual screening from a NCI small molecule library, but no data were available about its synthesis, stereochemistry, and physicochemical properties. We report here a synthetic route that allowed us to characterize and unambiguously identify the structure of the active compound by a combination of NMR spectroscopy and in silico conformational analysis. The synthetic protocol allowed us to sustain experiments aimed at assessing its therapeutic potential for the treatment of FGF-dependent lung cancers. A crucial step in the synthesis generated a c…

Use of Tiger Nut (Cyperus esculentus L.) Oil Emulsion as Animal Fat Replacement in Beef Burgers

2020

The present study evaluated the replacement of beef fat in beef burgers using a tiger nut (Cyperus esculentus L.) oil emulsion, in order to reduce total fat and saturated fatty acids in the studied samples. Three formulations were processed: Control&mdash

Photoelectrochemical characterization of amorphous anodic films on Ti-6at.%Si

2013

Abstract The solid state properties of anodic films grown galvanostatically on sputtering-deposited Ti–6at.%Si alloys were studied as a function of the formation voltage (5–40 V). From the photocurrent spectra a band gap of ∼3.4 eV was estimated for all the investigated thicknesses, which is almost coincident with the value measured for amorphous TiO 2 . The photocharacteristics allowed to estimate the flat band potential of the films, which resulted to be more anodic for thicker layers and allowed to evidence a change from n-type semiconducting material to insulator by increasing the formation voltage. A dielectric constant of ∼31 was estimated by differential capacitance measurements. The…

Photoelectrochemical evidence of Nitrogen Incorporation during Anodizing of Sputtering-Deposited Al-Ta alloys

2016

Anodic films were grown to 20 V on sputtering-deposited Al–Ta alloys in ammonium biborate and borate buffer solutions. According to glow discharge optical emission spectroscopy, anodizing in ammonium containing solution leads to the formation of N containing anodic layers. Impedance measurements did not evidence significant differences between the dielectric properties of the anodic films as a function of the anodizing electrolyte. Photoelectrochemical investigation allowed evidencing that N incorporation induces a red-shift in the light absorption threshold of the films due to the formation of allowed localized states inside their mobility gap. The estimated Fowler threshold for the intern…

Photoelectrochemical evidence of Nitrogen Incorporation during Anodizing of valve metals alloys

2015

Amorphous and/or nanocrystalline oxide films can be easily prepared electrochemically by anodizing. The anodizing allows to grow oxides with structural and compositional features easily and strictly controlled by the process parameters.

Physico-chemical characterization and corrosion properties of friction stir welded Al2024-T4 alloys

2009

Physico-chemical characterization of passive films on 316L stainless steel grown in high temperature water

2014

Physico-chemical approaches in materials investigations

2023

Physico-chemical characterization is the keystone to fully understand the material properties. This topical issue has collected almost 30 contributions reflecting the latest developments on the topic. It includes, but is not limited to spectroscopic characterization, characterisation of materials by using neutrons as source, development of alternative synthetic routes of nanoparticles, microwave assisted synthesis, preparation of polymeric nanocomposites, archaeometric investigation of ancient materials.

Identification of plant cells in black pigments of prehistoric Spanish Levantine rock art by means of a multi-analytical approach. A new method for s…

2017

We present a new multi-analytical approach to the characterization of black pigments in Spanish Levantine rock art. This new protocol seeks to identify the raw materials that were used, as well as reconstruct the different technical gestures and decision-making processes involved in the obtaining of these black pigments. For the first of these goals, the pictorial mat- ter of the black figurative motifs documented at the Les Dogues rock art shelter (Ares del Maestre, Castello ́ n, Spain) was characterized through the combination of physicochemical and archeobotanical analyses. During the first stage of our research protocol, in situ and non- destructive analyses were carried out by means of…

Polymeric C3N4 and O-doped C3N4: Photoelectrochemical and EPR Features for Selective Photocatalytic Oxidation of Alcohols to Aldehydes

2018

Polymeric C3N4 and O-doped C3N4: Photoelectrochemical and EPR Features for Selective Photocatalytic Oxidation of Alcohols to Aldehydes