Search results for "CIT"
showing 10 items of 22474 documents
Azacitidine-Containing Induction Regimens Followed by Azacitidine Maintenance Therapy in High Risk Acute Myeloid Leukemia: First Results of the Rando…
2012
Abstract Abstract 412 Background: A large proportion of patients are currently not eligible for genotype-adapted strategies in acute myeloid leukemia (AML), in particular those lacking specific genetic aberrations such as PML-RARA, CBFB-MYH11, RUNX1-RUNX1T1, NPM1 or activating FLT3 mutations. This subgroup of patients accounts for about one-third of all AML patients and mainly includes the large group of AML with myelodysplasia-related changes, AML with recurrent cytogenetic abnormalities [inv(3) or t(3;3), t(9;11), t(v;11q23)] and cytogenetically normal AML (CN-AML) with wild-type NPM1 and FLT3. Prognosis in this subgroup of patients is generally poor. Azacitidine has been shown to be acti…
A Single-Arm, Open-Label Phase 1 Study of Itacitinib (ITA) with Calcineurin Inhibitor (CNI)-Based Interventions for Prophylaxis of Graft-Versus-Host …
2020
Background Despite prophylaxis, GVHD remains a significant cause of morbidity and nonrelapse mortality after allogeneic hematopoietic cell transplantation (HCT). ITA is a potent, selective Janus kinase (JAK) 1 inhibitor that has been combined safely with steroids in patients (pts) with acute GVHD. We describe results from a proof-of-concept study evaluating ITA + CNI-based regimens for GVHD prophylaxis. Study Design and Methods GRAVITAS-119 (NCT03320642) was a single-arm, open-label study enrolling pts aged ≥18 y undergoing allogeneic HCT using peripheral blood stem cells from 8/8 or 7/8 matched related or unrelated donors for a hematologic malignancy. Eligible pts were candidates for reduc…
Posterior ‘Motion Preserving’ Procedures (Frykholm)
2019
Cervical radiculopathy from degenerative disease is a common problem with an incidence of 0.83–1.79 per 1000 person years. It can be caused by a cervical disc herniation, bony foraminal stenosis or spinal canal stenosis. Upon failure of conservative therapy or a significant motor deficit surgical treatment is indicated. A posterior cervical foraminotomy is one surgical option for the treatment of selected patients with lateral cervical disc herniations.
Normalwerterstellung von Blutströmungsgeschwindigkeiten an der Arteria mesenterica superior bei Früh- und Reifgeborenen mit der Duplexsonographie
1994
In a prospective study blood flow velocity measurements were performed in 110 "healthy" newborn with duplex Doppler sonography in the superior mesenteric artery to obtain standard values. In 49 of these neonates 15, 30, and 45 minutes following feeding examinations were performed. Peak systolic flow velocity, end systolic flow velocity, time average flow velocity and time average maximum flow velocity were determined, the resistance and Pourcelot index as well as the volume blood flow were calculated. The children's gestational age was 27-42 weeks, the postnatal age was 2-68 days and the body weight was 920-4190 g. All measured blood flow velocities showed a synchronous relation to feeding …
Long-term improvement of quality of life in adult ADHD – results of the randomized multimodal COMPAS trial
2021
Attention Deficit Hyperactivity Disorder (ADHD) negatively impacts Quality of Life (QoL) in adults. Earlier studies on pharmacological treatment have shown short-term beneficial effects on QoL. No data are available on long-term effects on multimodal psychosocial and/or pharmacological interventions. The Comparison of Methylphenidate and Psychotherapy in Adult ADHD Study (COMPAS), a prospective, multicenter randomized clinical trial, compared cognitive behavioral group psychotherapy (GPT) with individual clinical management (CM) and methylphenidate (MPH) with placebo (Plac) (2 × 2 factorial design over a period of 52 weeks). Change of QoL was measured after three months of intensive treatme…
The effect of conventional movement training and trampoline training on balance and gait in chronic hemiplegic patients
1991
The postural sway of subjects during standing both with their eyes open and closed together with maximum velocity of walking were analysed in six male chronic hemiplegic patients before, during and after an intensive movement training programme lasting 8 weeks. The movement training programme was carried out on the basis of Bobath's principles. Three of the subjects carried out their training on a trampoline, with the particular purpose of enhancing the stimulation of the mechanisms responsible for the control of balance. During the follow-up, maximal walking velocity remained at previous levels and no systematic changes were observed in the control of postural sway. Although the use of the…
Effects of wrist oscillations on contralateral neurological postural tremor using a new myohaptic device ('wristalyzer')
2007
Upper limb postural tremor consists of distinct oscillations, mainly mechanical-reflex and central-neurogenic. These oscillations are superimposed upon a background of irregular fluctuations in muscle force. Muscle spindles play key-roles in the information flow to supra-spinal and spinal generators. Oscillations were delivered using a new generation portable myohaptic device, called 'wristalyzer', which takes into account the ergonomy of upper limbs allowing a fine adjustment to each configuration of upper limb segments. The nominal torque of the device is 4 Nm, with a maximal rotation velocity of 300 degrees/s and a range of motion of +45 to -45 degrees. Reliability was assessed in basal …
Oral Idarubicin in Maintenance Therapy of Acute Myeloid Leukemia
2001
More than half of all acute myeloid leukaemia (AML) patients are over 60 years. The disease free survival (DFS) and overall survival (OS) rate of these patients is poor. These unsatisfactory results are associated with adverse cytogenetic characteristics, prior myelods-plasia, adverse phenotypic features, MDR and BCL2 overexpression. Furthermore a large fraction of patients achieving CR early relapses. This is due to two factors: acquired tumor cell drug resistance and tumor re-growth. Maintenance therapy could provide a means to keep leukemic growth under control. We enrolled 31 elderly previous responder patients to standard induction therapy to receive maintenance oral IDA 3mg/m2 daily d…
Multizentrische Phase II — Studie der Arbeitsgruppe Lebermetastasen zur wöchentlichen intraarteriellen 24 h Hochdosistherapie mit 5-FU und Folinsäure…
1998
This prospective multicenter trial was performed to determine the response rate, toxicity and applicability of continuous 24 h hepatic arterial infusion of high-dose 5-FU and folinic acid. An improved response rate (60.5% in non-pretreated patients) was however associated with many systemic side-effects (340/509), mainly nausea and diarrhea. Therefore this treatment should be applied only in selected patients in specialized centers.
Duplexsonographie abdomineller Gefäße
1987
Duplex sonography is a non-invasive procedure which permits the determination of flow velocity and direction in visceral vessels. Results in 50 normals have shown that small arteries can be evaluated in about 50% of cases. The portal venous system can be demonstrated in all cases; average flow velocity and volume is 15.2 +/- 2.8 cm/s and 694 +/- 230 ml/min, corresponding with the values obtained by invasive methods. Clinical application for duplex examinations can be found in portal hypertension, varices, thromboses, aneurysms and transplant kidneys.