Search results for "CIT"

The Role of Municipalities in Promoting Well-Being

2014

The aim of the paper is to research different approaches to researching and promoting the well-being in municipalities. To achieve the aim, such qualitative and quantitative methods of research as comparing, grouping, graphical analysis, focus group methods will be used. The main results and findings of the paper are: the role of municipalities in promoting well-being is increasing contrary to the role of national or regional authorities, due to the autonomous functions of local authorities, intensive informative links and a wide range of available economic and social instruments.

The Assessment of Well-being in Context of Regional Development

2014

The aim of the paper is to present the methodology and results of some empirical research of the assessment of well-being at local level in context of regional development. To achieve the aim, such qualitative and quantitative methods of research as comparing, grouping, graphical analysis and focus group methods were be used. The main result and finding of the paper is the conclusion that in order to promote the regional development of the territory, the assessment of well-being at the level of administrative territory is needed. Based on this assessment, the policy can be developed in order to promote the regional development and social cohesion of the territory, as well as to have better …

L'editto di Claudio del 44-45 d.C. e alcune concessioni agli abitanti di Volubilis

2012

The author deals with the issue concerning the conferment of various grants – including the Roman citizenship, and also the right of legal marriage with foreign women, immunity from taxation for ten years, new settlers, the right to the property of citizens killed in the war – by the Emperor Claudius in favor of the inhabitants of Volubilis in Mauretania through the analysis of three well-known inscriptions which record these benefits which the community have gained from Claudius: namely, IAMLat 369, 370a, 448.

Constant Power Model in Arm Rotation—A New Approach to Hill’s Equation

2014

The purpose of this study was to further develop the constant power model of a previous study and to provide the final solution of Hill’s force-velocity equation. Forearm and whole arm rotations of three different subjects were performed downwards (elbow and shoulder extension) and upwards (elbow and shoulder flexion) with maximum velocity. These arm rotations were recorded with a special camera system and the theoretically derived model of constant maximum power was fitted to the experimentally measured data. The moment of inertia of the arm sectors was calculated using immersion technique for determining accurate values of friction coefficients of elbow and whole arm rotations. The experi…

Modeling the force – velocity relationship in arm movement

2012

Modeling the force-velocity dependence of a muscle-tendon unit has been one of the most interesting objectives in the field of muscle mechanics. The so-called Hill’s equation [1,2] is widely used to describe the force-velocity relationship of muscle fibers. Hill’s equation was based on the laboratory measurements of muscle fibers and its application to the practical measurements in muscle mechanics has been problematic. Therefore, the purpose of this study was to develop a new explicit calculation method to determine the force-velocity relationship, and test its function in experimental measurements. The model was based on the motion analysis of arm movements. Experiments on forearm rotatio…

Modeling muscle mechanics of arm and leg movement : a new approach to Hill's equation

2015

Beneficial effects of running and milk protein supplements on Sirtuins and risk factors of metabolic disorders in rats with low aerobic capacity

2019

Background. Physical activity and dietary intake of dairy products are associated with improved metabolic health. Dairy products are rich with branched chain amino acids that are essential for energy production. To gain insight into the mechanisms underlying the benefit of the sub-chronic effects of running and intake of milk protein supplements, we studied Low Capacity Runner rats (LCR), a rodent exercise model with risk for metabolic disorders. We especially focused on the role of Sirtuins, energy level dependent proteins that affect many cellular metabolic processes. Methods. Forty-seven adult LCR female rats sedentary or running voluntarily in wheels were fed normal chow and given suppl…

Targeting CD34+ cells of the inflamed synovial endothelium by guided nanoparticles for the treatment of rheumatoid arthritis

2019

Abstract Despite the advances in the treatment of rheumatoid arthritis (RA) achieved in the last few years, several patients are diagnosed late, do not respond to or have to stop therapy because of inefficacy and/or toxicity, leaving still a huge unmet need. Tissue-specific strategies have the potential to address some of these issues. The aim of the study is the development of a safe nanotechnology approach for tissue-specific delivery of drugs and diagnostic probes. CD34 + endothelial precursors were addressed in inflamed synovium using targeted biodegradable nanoparticles (tBNPs). These nanostructures were made of poly-lactic acid, poly-caprolactone, and PEG and then coated with a synovi…

Posttraumatic Propofol Neurotoxicity Is Mediated via the Pro–Brain-Derived Neurotrophic Factor-p75 Neurotrophin Receptor Pathway in Adult Mice*

2016

Objectives:The gamma-aminobutyric acid modulator propofol induces neuronal cell death in healthy immature brains by unbalancing neurotrophin homeostasis via p75 neurotrophin receptor signaling. In adulthood, p75 neurotrophin receptor becomes down-regulated and propofol loses its neurotoxic effect. H

The utility of SATB2 immunohistochemical expression in distinguishing between osteosarcomas and their malignant bone tumor mimickers, such as Ewing s…

2016

SATB2 is commonly expressed in osteosarcomas. Although apparently being a valuable diagnostic marker for differentiating between small cell osteosarcoma (SCO) and other small round cell tumors of bone, for instance Ewing sarcoma family of tumors (ESFT), it has not been tested in a large series of ESFT and chondrosarcomas so far. We studied the immunohistochemical expression of SATB2 in 42 osteosarcomas, 31 chondrosarcomas, and 371 genetically confirmed ESFT. SATB2 positivity was detected in 90.4% of osteosarcomas, 87.5% of SCO, 91.3% of osteoblastic osteosarcomas, and in all chondroblastic and parosteal osteosarcomas. The osteoblastic and SCO subtypes expressed SATB2 more intensely than oth…