Search results for "CJD"

showing 4 items of 4 documents

Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration.

2014

Increased neurogenesis has been reported in neurodegenerative disease, but its significance is unclear. In a mouse model of prion disease, Gomez-Nicola et al. detect increased neurogenesis in the dentate gyrus that partially counteracts neuronal loss. Targeting neurogenesis may have therapeutic potential.

AdultMaleAntimetabolites AntineoplasticPatch-Clamp TechniquesTime FactorsPrionsNeurogenesisGenetic VectorsHippocampusTissue BanksBiologyHippocampal formationHippocampusCreutzfeldt-Jakob SyndromePrion DiseasesMiceYoung AdultNeural Stem CellsAlzheimer Diseasevariant CJDNeural PathwaysmedicineAnimalsHumansAgedCell ProliferationDentate gyrusNeurogenesisNeurodegenerationCytarabineNeurodegenerative DiseasesOriginal ArticlesMiddle Agedmedicine.diseaseNeural stem cellMice Inbred C57BLNeuroanatomical Tract-Tracing Techniquesadult neurogenesisDisease Models AnimalChronic DiseaseDentate GyrusMossy Fibers HippocampalDisease ProgressionFemaleNeurology (clinical)Alzheimer's diseaseNeuroscienceNeural developmentAlzheimer’s diseaseBrain : a journal of neurology
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14-3-3 in the cerebrospinal fluid of patients with variant and sporadic Creutzfeldt–Jakob disease measured using capture assay able to detect low lev…

2002

Abstract A protein capture assay was used to measure 14-3-3 (γ-isoform) in the cerebrospinal fluid (CSF) of patients with either variant or sporadic Creutzfeldt–Jakob disease (CJD). The results were compared with those obtained using Western blotting. Elevated levels of 14-3-3γ were found in 58% of variant CJD (vCJD) patients and 82% of sporadic CJD (spCJD) patients using the protein capture assay. Using a Western blotting technique, the presence of CSF 14-3-3γ was detected in 58% of vCJD patients and in 89% of spCJD patients. When the results from the protein capture assay and the Western blot were combined, 14-3-3γ was detected in 77% of vCJD patients and in 91% of spCJD patients. These r…

MalePathologymedicine.medical_specialtyTyrosine 3-MonooxygenaseAmino Acid MotifsBlotting WesternStatistics as TopicCreutzfeldt-Jakob SyndromeDiagnosis DifferentialCerebrospinal fluidDegenerative diseaseWestern blotPredictive Value of Testsmental disordersmedicineHumans14-3-3 proteinAgedNeuronsmedicine.diagnostic_testSporadic CJDbusiness.industryGeneral NeuroscienceBrainReproducibility of ResultsSporadic Creutzfeldt-Jakob diseaseMiddle Agedmedicine.diseaseVirologyUp-Regulationnervous system diseasesVariant cjdBlot14-3-3 ProteinsBiological AssayFemalebusinessBiomarkersNeuroscience Letters
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Mathematical models for the diffusion magnetic resonance signal abnormality in patients with prion diseases

2014

In clinical practice signal hyperintensity in the cortex and/or in the striatum on magnetic resonance (MR) diffusion-weighted images (DWIs) is a marker of sporadic Creutzfeldt–Jakob Disease (sCJD). MR diagnostic accuracy is greater than 90%, but the biophysical mechanisms underpinning the signal abnormality are unknown. The aim of this prospective study is to combine an advanced DWI protocol with new mathematical models of the microstructural changes occurring in prion disease patients to investigate the cause of MR signal alterations. This underpins the later development of more sensitive and specific image-based biomarkers. DWI data with a wide a range of echo times and diffusion weightin…

MalePathologysCJD sporadic Creutzfeldt–Jakob diseaseROI region of interestPrion diseasePrPSc prion protein scrapieElectroencephalographyFOV field of viewlcsh:RC346-429Prion DiseasesADC apparent diffusion coefficientTI inversion timeRPE rapidly progressive encephalopathyAged 80 and overTE echo timeBrain Mappingmedicine.diagnostic_testBrainRegular ArticleMiddle AgedBIC Bayesian information criterionTR repetition timemedicine.anatomical_structureNeurologylcsh:R858-859.7FemaleMPRAGE magnetization-prepared rapid acquisition gradient-echoAbnormalitySS-SE single shot spin-echoAdultmedicine.medical_specialtyCognitive NeuroscienceCreutzfeldt–Jakob diseaseCNR contrast to noise ratioEPI echo-planar imagingNeuropathologyPrPC prion protein cellularGrey matterSpongiform degenerationlcsh:Computer applications to medicine. Medical informaticsEEG electroencephalogramDiffusion MRINeuroimagingImage Interpretation Computer-AssistedmedicineHumansRadiology Nuclear Medicine and imaginglcsh:Neurology. Diseases of the nervous systemAgedCJD Creutzfeldt–Jakob diseaseGSS Gerstmann–Sträussler–Scheinker syndromebusiness.industryDWI diffusion weighted imagingDiffusion MRI; Biophysical models; Creutzfeldt-Jakob disease; Prion disease; Spongiform degenerationMagnetic resonance imagingModels TheoreticalHyperintensityCreutzfeldt-Jakob diseaseDiffusion Magnetic Resonance ImagingNeurology (clinical)businessBiophysical modelsDiffusion MRINeuroImage: Clinical
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Sietveida topoloģijas tīklu iespēju pētīšana un analīze

2015

Bakalaura darbs ir veltīts sietveida topoloģijas tīkliem. Bakalaura darbā tiks pētītas šādu tīklu pielietošanas iespējas, darbības īpatnības un īpašības. Darba beigās tiks iegūts un apkopots liels daudzums kvalitatīvas informācijas par sietveida topoloģijas pielietojumu praktiskā līmenī mūdsienās, kā arī par perspektīviem pētījumiem globāla sietveita tīkla izveidē. Darbā ir praktiski apskatīts un izmēģināts Hyperboria tīkls, kurš strādā uz, arī izpētīta darba ietvaros, cjdns protokola pamata. Darbā iekļautas zināšanas par sietveida tīkliem, to īpašībām, izmantojumu un perspektīvām, par cjdns un citiem protokoliem ļoti lielu sietveida tīklu efektīvai maršrutēšanai, kā arī par Hyperboria tīkl…

globāls sietveida tīklsDatorzinātnecjdnsHyperboriasietveida tīkliNetsukuku
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